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Keywords: Liver
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Biosci Rep (2022) BSR20212654.
Published: 20 January 2022
... of allosteric kinetics in human LDH-A is mirrored by a consistent dissociation of the enzyme tetramer, suggesting that pyruvate promotes tetramer association under acidic conditions. Finally, using the human liver cancer cell line HepG2 we isolated cells featuring cytosolic pH equal to 7.3 or 6.5, and we...
Biosci Rep (2021) 41 (10): BSR-2020-2022_COR.
Published: 18 October 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . G. Oblongata red algae Natural products LPS Liver Kidney Inflammation...
Biosci Rep (2021) 41 (1): BSR20202022.
Published: 15 January 2021
...Asmaa Nabil-Adam; Mohamed A. Shreadah Background: The liver and kidney inflammation due to bacterial infection is one of the most common pathological problems leading to tissue damage or disease. In many liver and kidney disorders, which represent serious global health burden with a high economic...
Biosci Rep (2019) 39 (4): BSR20181379.
Published: 23 April 2019
... of diabetes mellitus (DM) and verify the key metabolic pathways. Methods: Liver samples were collected from diabetic rats induced by streptozotocin (STZ) and rats in the control group at 1, 5, and 9 weeks after STZ administration. Proton nuclear magnetic resonance spectroscopy ( 1 H NMR)-based metabolomics...
Biosci Rep (2018) 38 (5): BSR20180536.
Published: 17 October 2018
... to low dose rate γ radiation originating from UT. We exposed C57BL/6J mice to 30, 100, or 250 μGy/h of gamma radiation originating from UT samples. Nine animals were included in each treatment group. We observed that the liver central vein was significantly enlarged in mice exposed to dose rates of 100...
Biosci Rep (2018) 38 (1): BSR20170977.
Published: 10 January 2018
...Yuning Pan; Aiqin Song; Shizhong Bu; Zhaoqian Chen; Qiuli Huang; Aijing Li Aim : To investigate the feasibility of low-concentration contrast (270 mg/ml) together with low tube voltage (80 kV) and adaptive iterative dose reduction (AIDR)-3D reconstruction in liver computed tomography (CT) perfusion...
Biosci Rep (2016) 36 (6): e00402.
Published: 03 November 2016
... relationships of steatosis and obesity with MRglu. Sixty patients referred for routine PET/CT had dynamic PET imaging over the abdomen for 30 min post-injection of F-18-fluorodeoxyglucose (FDG), followed by Patlak–Rutland graphical analysis of the liver using abdominal aorta for arterial input signal. The plot...
Biosci Rep (2016) 36 (4): e00360.
Published: 15 July 2016
... ) preclinical model of liver fibrosis in mice, we observed a significant increase in collagen deposition with increased expression and release of tissue inhibitors of metalloproteinase (TIMP)-1 both at 24 h and 3 weeks later. This suggests an early altered regulation of matrix turnover involved...
Biosci Rep (2014) 34 (6): e00160.
Published: 12 December 2014
... that silencing of ANGPTL3 improves insulin sensitivity. We further show that ANGPTL3 -silenced cells display a more pronounced shift from the secretion of TAG-enriched VLDL1-type particles to secretion of lipid poor VLDL2-type particles during insulin stimulation. These data suggest liver-specific mechanisms...
Biosci Rep (2010) 30 (2): 81–89.
Published: 10 November 2009
...María Del Mar Romero; José Antonio Fernández-López; Marià Alemany; Montserrat Esteve We intended to determine how the liver copes with the massive handling of lipids induced by OE (oleoyl-oestrone), as well as to characterize and differentiate the actual OE effects from those that may be only...
Includes: Supplementary data
Biosci Rep (2009) 29 (6): 385–395.
Published: 02 September 2009
... , with the most abundant expression in the hepatic caecum and hind-gut, agreeing with the notion that the hepatic caecum of amphioxus is the precursor of the vertebrate liver. 1 To whom correspondence should be addressed (email sczhang@ouc.edu.cn ). The nucleotide sequence data reported...
Biosci Rep (2008) 28 (5): 239–249.
Published: 11 September 2008
... by evaluating the pool of free amino acids and derivatives in highly-coupled purified liver mitochondria obtained from rats fed on a nutritionally adequate diet for growth. Our results indicated that the pool mainly reflects the amino acid composition of mtDNA-encoded proteins, suggesting that there is a post...
Includes: Supplementary data
Biosci Rep (2008) 28 (2): 107–115.
Published: 16 May 2008
... metabolism liver Glycerol and glyceraldehyde are two metabolites of intermediary metabolism, resulting from the breakdown of triacylglycerols and fructose respectively. These metabolites have important roles, acting as the links between several metabolic pathways, and undergo further metabolism...
Biosci Rep (2001) 21 (6): 873–877.
Published: 01 December 2001
...Gbenga A. Adenuga Ingestion of the mycotoxin Aflatoxin B 1 (AFB 1 ) by protein-undernourished Fischer F344 rats for twelve weeks resulted in significant ( p <0.05) increases in the proliferation of liver cells, reduced body weight and increased microsomal Ca 2+ -ATPase activity. Cyt. P 450...
Biosci Rep (2001) 21 (3): 271–285.
Published: 01 June 2001
... the effect of antioxidants in the diet on hypertensión and other disorders, less attention has been given to the evaluation of the role of specific dietary lipids in modulating endogenous antioxidant enzyme status. Previously, we have described that liver antioxidant enzyme activities may be modulated...
Biosci Rep (2000) 20 (2): 93–98.
Published: 01 April 2000
...Gbenga A. Adenuga The effect of protein undernutrition on the activity of the smoothendoplasmic reticulum (microsomal) Ca 2+ -ATPase (SERCA) wasinvestigated. After 12 weeks of ad libitum ingestion of low proteindiet (5% protein), a significant depression ( p <0.05) of liver ERCa 2+ -ATPase...
Biosci Rep (1999) 19 (2): 115–124.
Published: 01 April 1999
...Diane Seimetz; Eva Frei; Martina Schnölzer; Tore Kempf; Manfred Wiessler The asialoglycoprotein receptor (ASGP-R), which is responsible for the uptake of partially deglycosylated serum glycoproteins was isolated from bovine liver. The receptor was purified in one step from solubilized plasma...
Biosci Rep (1995) 15 (1): 15–20.
Published: 01 February 1995
... in the virgin animals. The fetuses of diabetic rats had a lower protein synthesis rate than those from controls, although they showed a higher protein synthesis rate than either their respective mothers or virgin rats. Liver RNA concentration was higher in control and diabetic, pregnant rats than in virgin rats...
Biosci Rep (1991) 11 (1): 1–6.
Published: 01 February 1991
...Cedomila Milin; Biserka Radosevic-Stasic; Madena Kirigin; Visnja Hinic; Daniel Rukavina; Per-Olof Berggren; Saud Efendic Effects of somatostatin (SOM) on tissue contents of proteins, total lipids and phospholipids were investigated in regenerating and intact liver tissue of Y-59 rats. Whereas SOM...
Biosci Rep (1991) 11 (1): 23–31.
Published: 01 February 1991
...S. Leoni; A. D'Alessandro; R. Conti; M. Marino; S. Spagnuolo; M. T. Mangiantini The circannual behaviour of glycosylation and protein synthesis in frog liver slices was studied following the incorporation of 3 H-galactose and 14 C-glucosamine into glycolipids and glycoproteins and 3 H-leucine...
Biosci Rep (1989) 9 (6): 701–707.
Published: 01 December 1989
... in pregnant and in estrogen-treated animals, with respect to normal values. On the contrary the surface expression was shown to be strongly enhanced only in the liver of pregnant rat. Therefore the modulation shown by this receptor system in pregnancy seems to be only partially estrogen-dependent. 25 5...
Biosci Rep (1989) 9 (5): 559–564.
Published: 01 October 1989
...Ferran Burgaya; Julia Peinado; Miquel Llobera; Ignasi Ramirez Hepatic endothelial lipase (HEL) activity is as high in the neonatal (1-day old) rat liver as in adults. Most of the HEL activity is located at the capillaries since 75% of the total activity is released by heparin or collagenase...
Biosci Rep (1989) 9 (5): 565–572.
Published: 01 October 1989
...M. Marino; S. Leoni; S. Spagnuolo; L. Conti Devirgiliis; M. T. Mangiantini The aim of the present report was to analyze the pattern of glycoprotein synthesis in rat liver on 19th and 22nd day of pregnancy by following the incorporation of 14 C-glucosamine and 3 H-galactose into isolated rat...
Biosci Rep (1987) 7 (7): 559–562.
Published: 01 July 1987
...Abdulrahim Abu-Jayyab; Ezz-Eddin S. M. El-Denshary; Mohamed M. El-Hakim Cyclic GMP contents of the thyroid gland and ovary were significantly increased in response to single and multiple treatments of bromocriptine, an effect which was antagonized by sulpiride. Liver and adrenocortical cyclic GMP...
Biosci Rep (1987) 7 (7): 593–597.
Published: 01 July 1987
...Ladislav Kümmel Effects of various ketogenic substrates on gluconeogenesis from lactate or alanine were compared. The results suggest that, in intact liver cells, cytoplasmic pyruvate is transported into mitochondria in exchange for intramitochondrially generated acetoacetate. An interrelationship...
Biosci Rep (1987) 7 (6): 465–470.
Published: 01 June 1987
...Nirmalendu Das; Mukul Kumar Basu; Manoj Kumar Das 125 Iodine labelled human immunoglobulin-G encapsulated liposomes were administered orally to rats. Distribution of radioactivity was checked in various tissues and in portal blood. The effect of dextran sulfate (DS 500,000 m. wt., liver blockade...