... haematopoietic stem cell transplantation Antigen presenting cell Graft-versus-host disease Inflammation Lymphocyte Xenogeneic graft-versus-host disease Graft-versus-host disease (GVHD) is an inflammatory disorder that can occur following allogeneic haematopoietic stem cell transplantation (HSCT) [ 1...

...Weifeng Tang; Shuchen Chen; Mingqiang Kang; Jun Liu; Chao Liu Background: Variants in B- and T-lymphocyte attenuator ( BTLA ) gene are likely to affect the function of BTLA protein. Methods: In the present case–control study, we selected BTLA tagging single-nucleotide polymorphisms (SNPs...

... homoeostasis in lymphocytes. In hypoxia, mTORC1 activity is reduced and shifts lipid synthesis to lipid oxidation. Moreover, knockdown tuberous sclerosis complex 1 (TSC1) constitutively activates mTORC1 activity and impairs the hypoxia-induced metabolic shift. Therefore, TSC1 knockdown enhances hypoxia-induced...

...Susumu Tonegawa Published in Les Prix Nobel (1988), printed in Sweden by Norsteds Tryckeri, Stockholm, Sweden, republished here with the permission of the Nobel Foundation, the copyright holder. © 1988 Plenum Publishing Corporation 1988 immune diversity lymphocyte receptors...

..., and immediately secreted without intracellular storage. In the case of lymphokine secretion by T lymphocytes, it is generally not clear whether this non-regulated pathway is also being used, as opposed to the “regulated” pathway which has been proposed to operate in the cytotoxic lymphocyte mechanism...