... enriched in the SFN3 group. The expressions of nine selected DEGs validated with qRT-PCR were in line with the RNA sequencing data. Furthermore, SFN treatment influenced lipid and protein metabolism related pathways including AMPK signaling, fatty acid metabolism signaling, cholesterol metabolism...

...Jiahui Li; Yutian Wei; Jiali Liu; Shupeng Cheng; Xia Zhang; Huaide Qiu; Jianan Li; Chuan He Increasing evidence has demonstrated that cancer cell metabolism is a critical factor in tumor development and progression; however, its role in glioblastoma (GBM) remains limited. In the present study, we...

... pathways or by reactive oxygen species (ROS). Adenosine A1 receptors (ADORA1) are known to be involved in ethanol metabolism; however, underlying mechanism is not well understood. For investigating how the intrinsic ADORA1 function in ethanol metabolism in normal human hepatocytes without interference...

... metabolic diseases and their production pathways are for instance candidate therapeutic targets for cancer treatments. The fatty acid de novo synthesis (FADNS) occurs in the cytoplasm, while the microsomal modification of fatty acids (MMFA) happens at the surface of the endoplasmic reticulum (ER...

... ± 0.03 for injured animals. Measurements were also made before euthanasia at 16 weeks post-injury. The average scores were 10.86 ± 0.92 for SCI-Chow and 11.91 ± 0.64 for SCI-HFD. diabetes glycemic control metabolism spinal cord injury Type-2 diabetes mellitus (T2DM) is a metabolic...

...Cameron A. Schmidt Mitochondria are central to the physiology and survival of nearly all eukaryotic cells and house diverse metabolic processes including oxidative phosphorylation, reactive oxygen species buffering, metabolite synthesis/exchange, and Ca 2+ sequestration. Mitochondria...

...Atanaska Dobreva; Erika Tatiana Camacho; Kamila Larripa; Anca Rǎdulescu; Deena R. Schmidt; Imelda Trejo This work analyzes a mathematical model for the metabolic dynamics of a cone photoreceptor, which is the first model to account for energy generation from fatty acids oxidation of shed...

... the burden of TB tremendously and new therapeutics to overcome the problem of drug resistance are urgently needed. Metabolism of Mtb and its interactions with the host is important for its survival and virulence; this is an important topic of research where there is growing interest in developing new...

...Yi-Huan Chen; Yi-Ju Wu; Wei-Cheng Chen; Tzong-Shyuan Lee; Tsui-Chun Tsou; Hsuan-Chia Chang; Sheng-Wen Lo; Shen-Liang Chen Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer frequently leached out from polyvinyl chloride (PVC) products and is quickly metabolized to its monoester equivalent mono(2...

...Lauren A. Mills; Alistair J. McCormick; David J. Lea-Smith Cyanobacteria are key organisms in the global ecosystem, useful models for studying metabolic and physiological processes conserved in photosynthetic organisms, and potential renewable platforms for production of chemicals. Characterizing...

...Minjiang Chen; Hong Zheng; Min Xu; Liangcai Zhao; Qianqian Zhang; Jingjing Song; Zhongwei Zhao; Siming Lu; Qiaoyou Weng; Xulu Wu; Weibin Yang; Xiaoxi Fan; Hongchang Gao; Jiansong Ji Background: The present study aimed to explore the changes in the hepatic metabolic profile during the evolution...

... in pentose phosphate pathway, glycolysis, and tricarboxylic acid cycle as well as mitochondrial adenosine triphosphate biosynthesis. These findings may offer important insight into the metabolic alterations in THS-treated gut injury, which will be helpful for developing effective metabolites-based strategies...

... phenotypes or building genome-scale metabolic models. In this case, the mutation concerned appears to map to an enzyme in one of the little-known but essential metabolite repair pathways that have been discovered in recent years. However, the bioinformatic and experimental evidence presented suggests...

...Liyuan Zhou; Xinhua Xiao Obesity is considered a global epidemic. Specifically, obesity during pregnancy programs an increased risk of the offspring developing metabolic disorders in addition to the adverse effects on the mother per se . Large numbers of human and animal studies have demonstrated...

... how hyperpolarized contrast media, used in combination with MR data acquisition methods, may advance our ability to assess oxygen metabolism non-invasively and thus improve management of clinical disease. We first introduce the concept of hyperpolarization and how hyperpolarized contrast media have...

... as far as the origin of life, which they facilitated by removal of atmospheric dihydrogen, H 2 . Moreover, as electron acceptors, antireductants equipped the first metabolic pathways, enabling lithoautotrophic microbial growth. When the Earth's atmosphere became more oxidizing, certain antireductants...

...Zhi-qin Li; Xin-yu Gu; Jin-xing Hu; Yu Ping; Hua Li; Jing-ya Yan; Juan Li; Ran Sun; Zu-jing Yu; Yi Zhang It has been suggested that Hepatitis C virus (HCV) core protein is associated with metabolic disorders of liver cell. However, the precise mechanism is still unclear. The aim of the present...

... undernutrition. Results reveal the negative impact of suboptimal maternal nutrition on adult offspring cardiac energy metabolism, which may have life-long implications for cardiovascular function and disease risk. 1 To whom correspondence should be addressed (email [email protected] ). 5 1 2015...

...–Seip Congenital lipodystrophy type 2), resulting from mutations in the BSCL2/seipin gene, exhibits the most severe lipodystrophic phenotype with loss of both metabolic and mechanical adipose depots. The majority of Seipin mutations cause C-terminal truncations, along with a handful of point mutations...

...Eduardo Nunes Chini; Claudia C. S. Chini; Veronica Nin; Carlos Escande DBC1 (deleted in breast cancer-1) is a nuclear protein that regulates cellular metabolism. Since alteration in cellular metabolism have been proposed to be the emerging ‘hallmark’ of cancer, it is possible that DBC1 may...

... the poor secretory response of HIT-T15 cells to KIC 17 12 1991 15 1 1992 © 1992 Plenum Publishing Corporation 1992 pancreatic islets HIT-T15 cells 2-ketoisocaproate transport metabolism Bioscience Reports, Vol. 12, No. I, 1992 2-Ketoisocaproate Transport in Insulin- Secreting...