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YAP signaling orchestrates the endothelin-1-guided invadopodia formation in high-grade serous ovarian cancer

Piera Tocci, Valentina Caprara, Celia Roman, Rosanna Sestito, Laura Rosanò, Anna Bagnato

Biosci Rep (2024) 44 (12): BSR20241320.

https://doi.org/10.1042/BSR20241320

Published: 29 November 2024

...). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . endothelin-1 receptor invadopodia metastasis ovarian cancer YAP Fondazione AIRC per la ricerca...

View articletitled, YAP signaling orchestrates the endothelin-1-guided invadopodia formation in high-grade serous ovarian cancer

Includes: Supplementary data

Articles

Retraction: Ultrasonic irradiation and SonoVue microbubbles-mediated RNA interfering targeting PRR11 inhibits breast cancer cells proliferation and metastasis but promotes apoptosis

Biosci Rep (2024) 44 (9): BSR-2020-1854_RET.

https://doi.org/10.1042/BSR-2020-1854_RET

Published: 10 September 2024

... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis metastasis microbubble proliferation Proline-rich protein 11...

View articletitled, Retraction: Ultrasonic irradiation and SonoVue microbubbles-mediated RNA interfering targeting PRR11 inhibits breast cancer cells proliferation and metastasis but promotes apoptosis

Articles

Retraction: MIR600HG suppresses metastasis and enhances oxaliplatin chemosensitivity by targeting ALDH1A3 in colorectal cancer

Biosci Rep (2024) 44 (9): BSR-2020-0390_RET.

https://doi.org/10.1042/BSR-2020-0390_RET

Published: 10 September 2024

... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ALDH1A3 Chemosensitivity colorectal cancer Metastasis MIR600HG...

View articletitled, Retraction: MIR600HG suppresses metastasis and enhances oxaliplatin chemosensitivity by targeting ALDH1A3 in colorectal cancer

Articles

Tamoxifen metabolites treatment promotes ERα+ transition to triple negative phenotype in vitro , effects of LDL in chemoresistance

Andrea Muñoz-Ayala, Brenda Chimal-Vega, Nicolás Serafín-Higuera, Octavio Galindo-Hernández, Gladys Ramírez-Rosales, Iván Córdova-Guerrero, Luis Fernando Gómez-Lucas, Victor García-González

Biosci Rep (2024) 44 (8): BSR20240444.

https://doi.org/10.1042/BSR20240444

Published: 05 August 2024

... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . breast cancers chemoresistance metastasis Nrf2 tamoxifen Consejo...

View articletitled, Tamoxifen metabolites treatment promotes ERα+ transition to triple negative phenotype in vitro , effects of LDL in chemoresistance

Includes: Supplementary data

Articles

Correction: Long non-coding RNA SPRY4-IT1 promotes epithelial-mesenchymal transition of cervical cancer by regulating the miR-101-3p/ZEB1 axis

Biosci Rep (2024) 44 (7): BSR-2018-1339_COR.

https://doi.org/10.1042/BSR-2018-1339_COR

Published: 31 July 2024

... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cervical Cancer EMT Long non-coding RNA metastasis SPRY4-IT1...

View articletitled, Correction: Long non-coding RNA SPRY4-IT1 promotes epithelial-mesenchymal transition of cervical cancer by regulating the miR-101-3p/ZEB1 axis

Articles

Retraction: LINC00636 promotes lymph node metastasis and of cervical cancer through target NM23

Biosci Rep (2024) 44 (1): BSR-2020-0367_RET.

https://doi.org/10.1042/BSR-2020-0367_RET

Published: 31 January 2024

... LINC00636 metastasis NM23 ...

View articletitled, Retraction: LINC00636 promotes lymph node metastasis and of cervical cancer through target NM23

Articles

Commentary on: The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells

Xin Zhang, Jiadi He, Dong Ren

Biosci Rep (2023) 43 (9): BSR20230057.

https://doi.org/10.1042/BSR20230057

Published: 11 September 2023

... promoted cancer cell migration in vitro and metastasis in vivo . The latest research from Sabine’s team has demonstrated that in H1299 lung cancer cells, the mechanism by which ITPKA promoted migration and invasion was predominantly depending on the ability of binding to F-actin, which will induce cancer...

View articletitled, Commentary on: The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells

Articles

Retraction: Up-regulated microRNA-500a enhances hepatocarcinoma metastasis by repressing PTEN expression

Biosci Rep (2023) 43 (4): BSR-2017-0837_RET.

https://doi.org/10.1042/BSR-2017-0837_RET

Published: 21 April 2023

... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . AKT Hepatocarcinoma Metastasis MiR-500a This Retraction follows...

View articletitled, Retraction: Up-regulated microRNA-500a enhances hepatocarcinoma metastasis by repressing PTEN expression

Articles

Retraction: Knockdown of TMEM14A expression by RNAi inhibits the proliferation and invasion of human ovarian cancer cells

Biosci Rep (2023) 43 (4): BSR-2015-0258_RET.

https://doi.org/10.1042/BSR-2015-0258_RET

Published: 21 April 2023

... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . TMEM14A cell cycle metastasis ovarian cancer This Retraction follows...

View articletitled, Retraction: Knockdown of TMEM14A expression by RNAi inhibits the proliferation and invasion of human ovarian cancer cells

Articles

Retraction: MicroRNA-802 inhibits epithelial-mesenchymal transition through targeting Flotillin-2 in human prostate cancer

Biosci Rep (2023) 43 (3): BSR-2016-0521_RET.

https://doi.org/10.1042/BSR-2016-0521_RET

Published: 01 March 2023

... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . epithelial-mesenchymal transition Flot2 metastasis microRNA-802 prostate...

View articletitled, Retraction: MicroRNA-802 inhibits epithelial-mesenchymal transition through targeting Flotillin-2 in human prostate cancer

Articles

The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells

Lukas Küster, Themistoklis Paraschiakos, Kader Ebru Karakurt, Udo Schumacher, Björn-Philipp Diercks, Sabine Windhorst

Biosci Rep (2023) 43 (2): BSR20222150.

https://doi.org/10.1042/BSR20222150

Published: 09 February 2023

... one metastasis is shown (see also magnification in the lower panel), which is embedded in normal lung tissue. Figure 1 Knock-down of ITPKA strongly reduces formation of distant metastasis in mice ( A ) H1299 control and H1299 ITPKA knock-down cells [ 4 ] were subcutaneously injected...

View articletitled, The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells

Includes: Supplementary data

Articles

Expression of Concern: Knockdown of TMEM14A expression by RNAi inhibits the proliferation and invasion of human ovarian cancer cells

Biosci Rep (2023) 43 (2): BSR-2015-0258_EOC.

https://doi.org/10.1042/BSR-2015-0258_EOC

Published: 09 February 2023

... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell cycle metastasis ovarian cancer THEM14A The Editorial Office has...

View articletitled, Expression of Concern: Knockdown of TMEM14A expression by RNAi inhibits the proliferation and invasion of human ovarian cancer cells

Articles

Expression of Concern: Up-regulated microRNA-500a enhances hepatocarcinoma metastasis by repressing PTEN expression

Biosci Rep (2023) 43 (2): BSR-2017-0837_EOC.

https://doi.org/10.1042/BSR-2017-0837_EOC

Published: 09 February 2023

View articletitled, Expression of Concern: Up-regulated microRNA-500a enhances hepatocarcinoma metastasis by repressing PTEN expression

Articles

Retraction: Overexpression of Cosmc suppresses cell migration and invasion in different subtypes of breast cancer cells via Tn and T glycans

Biosci Rep (2022) 42 (9): BSR-2019-1062_RET.

https://doi.org/10.1042/BSR-2019-1062_RET

Published: 21 September 2022

... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Apoptosis Breast cancer Cosmc Metastasis Proliferation Tn and T glycans...

View articletitled, Retraction: Overexpression of Cosmc suppresses cell migration and invasion in different subtypes of breast cancer cells via Tn and T glycans

Articles

Retraction: MiR-16-5p inhibits breast cancer by reducing AKT3 to restrain NF-kB pathway

Biosci Rep (2022) 42 (7): BSR-2019-1611_RET.

https://doi.org/10.1042/BSR-2019-1611_RET

Published: 27 July 2022

... the article. The Editor-in-Chief and Editorial Board agree with the Retraction. AKT3 breast cancer metastasis miRNA NF-κB © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative...

View articletitled, Retraction: MiR-16-5p inhibits breast cancer by reducing AKT3 to restrain NF-kB pathway

Articles

Polymeric biocompatible iron oxide nanoparticles labeled with peptides for imaging in ovarian cancer

In Collection

Bionanotechnology and Synthetic Biology: applications in precision medicine and allied fields

Deepshikha Shahdeo, Akanksha Roberts, Veerbhan Kesarwani, Milena Horvat, Raghuraj Singh Chouhan, Sonu Gandhi

Biosci Rep (2022) 42 (2): BSR20212622.

https://doi.org/10.1042/BSR20212622

Published: 11 February 2022

..., leukemias, lymphomas indicating invasion and metastasis [ 3–7 ]. uPAR belongs to a family of proteins called the lymphocyte antigen 6 which have a globular structure consisting of five to six antiparallel β-strands linked via four to five disulfide bonds [ 8 , 9 ]. It comprises three domains; D1, D2, D3...

View articletitled, Polymeric biocompatible iron oxide nanoparticles labeled with peptides for imaging in ovarian cancer

Includes: Supplementary data

Articles

Deregulation of ribosomal proteins in human cancers

Wendy El Khoury, Zeina Nasr

Biosci Rep (2021) 41 (12): BSR20211577.

https://doi.org/10.1042/BSR20211577

Published: 17 December 2021

... tumorigenesis and cell transformation. In this review, we will focus on the recent advances that shed light on the effects of RPs deregulation in different types of cancer and their roles in regulating the tumor cell fate. apoptosis Cancer cell survival metastasis ribosomal proteins Ribosomes...

View articletitled, Deregulation of ribosomal proteins in human cancers

Articles

Identification of CCT3 as a prognostic factor and correlates with cell survival and invasion of head and neck squamous cell carcinoma

Yan Wang, Peicheng Liu, Ziwei Zhang, Jiulong Wang, Zhigang Cheng, Chengchao Fan

Biosci Rep (2021) 41 (10): BSR20211137.

https://doi.org/10.1042/BSR20211137

Published: 19 October 2021

... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . CCT3 cell survival HNSCC metastasis prognostic factor Head and neck cancer (HNC) is a common malignant worldwide and causes more than...

View articletitled, Identification of CCT3 as a prognostic factor and correlates with cell survival and invasion of head and neck squamous cell carcinoma

Includes: Supplementary data

Articles

Digoxin exerts anticancer activity on human nonsmall cell lung cancer cells by blocking PI3K/Akt pathway

Yingying Wang, Yongqiang Hou, Lanjiao Hou, Wei Wang, Ke Li, Zhe Zhang, Bo Du, Dexin Kong

Biosci Rep (2021) 41 (10): BSR20211056.

https://doi.org/10.1042/BSR20211056

Published: 06 October 2021

... after treatment with digoxin, with an increase in autophagosome foci. In addition, digoxin inhibited the phosphorylation of Akt, mTOR and p70S6K, signaling molecules of the PI3K/Akt pathway that are known to be involved in tumor cell survival, proliferation, metastasis and autophagy. Our findings...

View articletitled, Digoxin exerts anticancer activity on human nonsmall cell lung cancer cells by blocking PI3K/Akt pathway

Includes: Supplementary data

Articles

Retraction: Relationship between microRNA-27a and efficacy of neoadjuvant chemotherapy in gastric cancer and its mechanism in gastric cancer cell growth and metastasis

Biosci Rep (2021) 41 (8): BSR-2018-1175_RET.

https://doi.org/10.1042/BSR-2018-1175_RET

Published: 06 August 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell growth Gastric cancer Metastasis MicroRNA-27a Neoadjuvant...

View articletitled, Retraction: Relationship between microRNA-27a and efficacy of neoadjuvant chemotherapy in gastric cancer and its mechanism in gastric cancer cell growth and metastasis

Articles

Glycogen synthase kinase 3β promotes osteosarcoma invasion and migration via regulating PTEN and phosphorylation of focal adhesion kinase

Wei Mai, Lingyu Kong, Hongwei Yu, Junjie Bao, Chunyu Song, Guofan Qu

Biosci Rep (2021) 41 (7): BSR20193514.

https://doi.org/10.1042/BSR20193514

Published: 26 July 2021

...Wei Mai; Lingyu Kong; Hongwei Yu; Junjie Bao; Chunyu Song; Guofan Qu Aim: Typical features of human osteosarcoma are highly invasive and migratory capacities. Our study aimed to investigate the roles of glycogen synthase kinase 3β (GSK3β) in human osteosarcoma metastasis. Methods: GSK3β expressions...

View articletitled, Glycogen synthase kinase 3β promotes osteosarcoma invasion and migration via regulating PTEN and phosphorylation of focal adhesion kinase

Articles

The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis

Haomeng Zhang, Jiao Wang, Yulong Yin, Qingjie Meng, Yonggang Lyu

Biosci Rep (2021) 41 (2): BSR20203121.

https://doi.org/10.1042/BSR20203121

Published: 03 February 2021

...Haomeng Zhang; Jiao Wang; Yulong Yin; Qingjie Meng; Yonggang Lyu Triple-negative breast cancer (TNBC) is the most malignant and fatal subtype of breast cancer, which has characterized by negativity expression of ER, PR, and HER2. Metastasis is the main factor affecting the prognosis of TNBC...

View articletitled, The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis

Articles

Total saponins from Rubus parvifolius L. inhibits cell proliferation, migration and invasion of malignant melanoma in vitro and in vivo

Jinfeng Cao, Xue Zhao, Yan Ma, Jian Yang, Fuqiang Li

Biosci Rep (2021) 41 (1): BSR20201178.

https://doi.org/10.1042/BSR20201178

Published: 22 January 2021

... into five groups: Vehicle, cyclophosphamide (CTX, 20 mg/kg), TSRP (25 mg/kg), TSRP (50 mg/kg) and TSRP (100 mg/kg) groups for 14 days’ treatment. In addition, the melanoma metastasis in lung in vivo of TSRP was detected in A375 tail vein injection mice, and the histopathalogical analysis of the lung...

View articletitled, Total saponins from Rubus parvifolius L. inhibits cell proliferation, migration and invasion of malignant melanoma in vitro and in vivo

Articles

miR-152/TNS1 axis inhibits non-small cell lung cancer progression through Akt/mTOR/RhoA pathway

Jinjin Duan, Li Wang, Liqun Shang, Shumei Yang, Hua Wu, Yongcheng Huang, Yi Miao

Biosci Rep (2021) 41 (1): BSR20201539.

https://doi.org/10.1042/BSR20201539

Published: 04 January 2021

... was assessed by RT-PCR and Western blot. Besides, Kaplan–Meier survival analysis was recruited to explore the association between TNS1 and NSCLC. Cell growth was analyzed by MTT and flow cytometry assay, while cell metastasis was determined by wound healing and transwell assays. The targeting relationship...

View articletitled, miR-152/TNS1 axis inhibits non-small cell lung cancer progression through Akt/mTOR/RhoA pathway

Articles

Ultrasonic irradiation and SonoVue microbubbles-mediated RNA interference targeting PRR11 inhibits breast cancer cells proliferation and metastasis, but promotes apoptosis

Hui Luo, Jian Li, Qi Lin, Xiaojun Xiao, Yang Shi, Xiuqin Ye, Zhanghong Wei, Yingying Liu, Jinfeng Xu

Biosci Rep (2020) 40 (11): BSR20201854.

https://doi.org/10.1042/BSR20201854

Published: 02 November 2020

... suggested that PRR11 was up-regulated in breast cancer. Silencing PRR11 mediated by US showed a higher efficiency than by Lipofectamine 3000. SiPRR11 transfected by Lipofectamine 3000 suppressed cells growth and metastasis, while promoted cell apoptosis. Moreover, E-cadherin (E-cad) and Bax expressions were...

View articletitled, Ultrasonic irradiation and SonoVue microbubbles-mediated RNA interference targeting PRR11 inhibits breast cancer cells proliferation and metastasis, but promotes apoptosis

Articles

LINC00636 promotes lymph node metastasis and cervical cancer through targeting NM23

Yue Zhong, Qiang Lu, Wei Qiu, Yan Luo

Biosci Rep (2020) 40 (10): BSR20200367.

https://doi.org/10.1042/BSR20200367

Published: 30 October 2020

...Yue Zhong; Qiang Lu; Wei Qiu; Yan Luo Background: Metastasis is a major obstacle in treatment of cervical cancer, and long non-coding RNA (lncRNA) mediated regulatory effect on associated genes expression is found to be involved in metastasis. However, its mechanisms have not been fully elucidated...

View articletitled, LINC00636 promotes lymph node metastasis and cervical cancer through targeting NM23

Includes: Supplementary data

Articles

Identification of a subpopulation of long-term tumor-initiating cells in colon cancer

Linglong Peng, Yongfu Xiong, Rong Wang, Ling Xiang, He Zhou, Haitao Gu

Biosci Rep (2020) 40 (8): BSR20200437.

https://doi.org/10.1042/BSR20200437

Published: 25 August 2020

... – 45 10.1038/nrm1004 12511867 16. Orian-Rousseau V. ( 2010 ) CD44, a therapeutic target for metastasising tumours . Eur. J. Cancer 46 , 1271 – 1277 10.1016/j.ejca.2010.02.024 20303742 17. Naor D. , Sionov R.V. and Ish-Shalom D. ( 1997 ) CD44...

View articletitled, Identification of a subpopulation of long-term tumor-initiating cells in colon cancer

Articles

Correction: Isorhamnetin inhibited migration and invasion via suppression of Akt/ERK-mediated epithelial-to-mesenchymal transition (EMT) in A549 human non-small cell lung cancer cells

Biosci Rep (2020) 40 (8): BSR-20190159_COR.

https://doi.org/10.1042/BSR-20190159_COR

Published: 07 August 2020

... 4.0 (CC BY) . Isorhamnetin Lung cancer Metastasis Epithelial-mesenchymal transition (EMT) Akt/ERK1/2 This Correction follows an Expression of Concern relating to this article previously published by Portland Press. The authors of the original paper “Isorhamnetin inhibited migration...

View articletitled, Correction: Isorhamnetin inhibited migration and invasion via suppression of Akt/ERK-mediated epithelial-to-mesenchymal transition (EMT) in A549 human non-small cell lung cancer cells

Articles

Expression of Concern: Relationship between microRNA-27a and efficacy of neoadjuvant chemotherapy in gastric cancer and mechanism in gastric cancer cell growth and metastasis

Biosci Rep (2020) 40 (7): BSR-20181175_EOC.

https://doi.org/10.1042/BSR-20181175_EOC

Published: 29 July 2020

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell growth Efficacy Gastric cancer Metastasis MicroRNA-27a Neoadjuvant...

View articletitled, Expression of Concern: Relationship between microRNA-27a and efficacy of neoadjuvant chemotherapy in gastric cancer and mechanism in gastric cancer cell growth and metastasis

Articles

Identification of prognostic and metastasis-related alternative splicing signatures in hepatocellular carcinoma

Runzhi Huang, Gaili Yan, Hanlin Sun, Jie Zhang, Dianwen Song, Rui Kong, Penghui Yan, Peng Hu, Aiqing Xie, Siqiao Wang, Juanwei Zhuang, Huabin Yin, Tong Meng, Zongqiang Huang

Biosci Rep (2020) 40 (7): BSR20201001.

https://doi.org/10.1042/BSR20201001

Published: 15 July 2020

... of cancer deaths worldwide. Its high-frequency metastasis and relapse rate lead to the poor survival of HCC patients. However, the mechanism of HCC metastasis is still unclear. Alternative splicing events (ASEs) have a great effect in cancer development, progression and metastasis. We downloaded RNA...

View articletitled, Identification of prognostic and metastasis-related alternative splicing signatures in hepatocellular carcinoma

Includes: Supplementary data

Articles

Expression of Concern: Isorhamnetin inhibited migration and invasion via suppression of Akt/ERK-mediated epithelial-to-mesenchymal transition (EMT) in A549 human non-small cell lung cancer cells

Biosci Rep (2020) 40 (7): BSR-20190159_EOC.

https://doi.org/10.1042/BSR-20190159_EOC

Published: 30 June 2020

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Isorhamnetin Lung cancer Metastasis Epithelial-mesenchymal transition (EMT...

View articletitled, Expression of Concern: Isorhamnetin inhibited migration and invasion via suppression of Akt/ERK-mediated epithelial-to-mesenchymal transition (EMT) in A549 human non-small cell lung cancer cells

Articles

Overexpression of Cosmc suppresses cell migration and invasion in different subtypes of breast cancer cells via Tn and T glycans

Jun Liu, Feng Xu, Jie Li, Hongchuan Jiang

Biosci Rep (2020) 40 (6): BSR20191062.

https://doi.org/10.1042/BSR20191062

Published: 17 June 2020

...Jun Liu; Feng Xu; Jie Li; Hongchuan Jiang Objectives: The high mortality of breast cancer (BC) is associated with the strong metastatic properties of primary breast tumor cells. The present study was conducted in order to clarify the effect of Cosmc on the growth and metastasis of BC cell lines...

View articletitled, Overexpression of Cosmc suppresses cell migration and invasion in different subtypes of breast cancer cells via Tn and T glycans

Articles

MIR600HG suppresses metastasis and enhances oxaliplatin chemosensitivity by targeting ALDH1A3 in colorectal cancer

Yi Yao, Nan Li

Biosci Rep (2020) 40 (4): BSR20200390.

https://doi.org/10.1042/BSR20200390

Published: 28 April 2020

...Yi Yao; Nan Li Background: Metastasis and chemoresistance indicate a poor prognosis in colorectal cancer (CRC) patients. However, the mechanisms that lead to the development of chemoresistance and metastasis in CRC remain unclear. Materials and methods: We combined clinical and experimental studies...

View articletitled, MIR600HG suppresses metastasis and enhances oxaliplatin chemosensitivity by targeting ALDH1A3 in colorectal cancer

Articles

The construction and analysis of tumor-infiltrating immune cells and ceRNA networks in metastatic adrenal cortical carcinoma

Runzhi Huang, Ziqi Liu, Tingli Tian, Dianwen Song, Penghui Yan, Huabin Yin, Peng Hu, Xiaolong Zhu, Yihan Liu, Zhenyu Li, Tong Meng, Jie Zhang, Zongqiang Huang

Biosci Rep (2020) 40 (3): BSR20200049.

https://doi.org/10.1042/BSR20200049

Published: 27 March 2020

... cortical carcinoma (ACC). Methods: A ceRNA network was established to identify the ceRNAs involved in metastasis of ACC based on 92 samples from TCGA, including 18 cases of metastasis and 74 cases of non-metastatic primary tumors. And the algorithm “cell type identification by estimating relative subsets...

View articletitled, The construction and analysis of tumor-infiltrating immune cells and ceRNA networks in metastatic adrenal cortical carcinoma

Includes: Supplementary data

Articles

Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways

Mao-lin Wan, Yu Wang, Zhi Zeng, Bo Deng, Bi-sheng Zhu, Ting Cao, Yu-kun Li, Jiao Xiao, Qi Han, Qing Wu

Biosci Rep (2020) 40 (3): BSR20200265.

https://doi.org/10.1042/BSR20200265

Published: 20 March 2020

..., ErbB, RHOA, Notch, BMP, Hippo, AMPK, NF-κB, MAPK and JNK. Subsequently, we discussed the biological function of these pathways in pathophysiological aspects of CRC, such as proliferation, apoptosis and metastasis. Finally, we summarized important interactions among these pathways in CRC. We believe...

View articletitled, Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways

Articles

Isorhamnetin inhibited the proliferation and metastasis of androgen-independent prostate cancer cells by targeting the mitochondrion-dependent intrinsic apoptotic and PI3K/Akt/mTOR pathway

Fangzhen Cai, Yanmei Zhang, Jianwei Li, Sihuai Huang, Ruilin Gao

Biosci Rep (2020) 40 (3): BSR20192826.

https://doi.org/10.1042/BSR20192826

Published: 18 March 2020

... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Apoptosis Isorhamnetin Metastasis PI3K/Akt/mTOR Prostate cancer Prostate cancer represents as one of the most commonly diagnosed cancer in the United States...

View articletitled, Isorhamnetin inhibited the proliferation and metastasis of androgen-independent prostate cancer cells by targeting the mitochondrion-dependent intrinsic apoptotic and PI3K/Akt/mTOR pathway

Articles

miR-492 promotes chemoresistance to CDDP and metastasis by targeting inhibiting DNMT3B and induces stemness in gastric cancer

Shuai Wu, Jian Xie, Hao Shi, Zi-wei Wang

Biosci Rep (2020) 40 (3): BSR20194342.

https://doi.org/10.1042/BSR20194342

Published: 09 March 2020

...Shuai Wu; Jian Xie; Hao Shi; Zi-wei Wang Objective: Metastasis and chemoresistance indicate treatment fail and progresses in gastric cancer (GC) patients. However, the molecular mechanisms of chemoresistance and metastasis remain unclear in GC. Thus, identifying the biological indicators...

View articletitled, miR-492 promotes chemoresistance to CDDP and metastasis by targeting inhibiting DNMT3B and induces stemness in gastric cancer

Includes: Supplementary data

Articles

SKA3 promotes lung adenocarcinoma metastasis through the EGFR–PI3K–Akt axis

Dan-dan Hu, Hai-ling Chen, Li-ming Lou, Hong Zhang, Guo-liang Yang

Biosci Rep (2020) 40 (2): BSR20194335.

https://doi.org/10.1042/BSR20194335

Published: 28 February 2020

...Dan-dan Hu; Hai-ling Chen; Li-ming Lou; Hong Zhang; Guo-liang Yang The processes that lead to lung adenocarcinoma (LUAD) metastasis are poorly characterized. Spindle and kinetochore associated complex subunit 3 (SKA3) plays a key role in cervical cancer development, but its contribution to LUAD...

View articletitled, SKA3 promotes lung adenocarcinoma metastasis through the EGFR–PI3K–Akt axis

Articles

Isorhamnetin inhibited migration and invasion via suppression of Akt/ERK-mediated epithelial-to-mesenchymal transition (EMT) in A549 human non-small-cell lung cancer cells

Wei Luo, Qingbin Liu, Nan Jiang, Mingquan Li, Li Shi

Biosci Rep (2019) 39 (9): BSR20190159.

https://doi.org/10.1042/BSR20190159

Published: 20 September 2019

...Wei Luo; Qingbin Liu; Nan Jiang; Mingquan Li; Li Shi In the present study, we investigated the potential effects of Isorhamnetin on the growth and metastasis of A549 human lung cancer cells, as well as the underlying mechanism. Treatment with Isorhamnetin exhibited a dose- and time-dependent...

View articletitled, Isorhamnetin inhibited migration and invasion via suppression of Akt/ERK-mediated epithelial-to-mesenchymal transition (EMT) in A549 human non-small-cell lung cancer cells

Articles

LncRNA LUCAT1 facilitates tumorigenesis and metastasis of triple-negative breast cancer through modulating miR-5702

Exian Mou, Hao Wang

Biosci Rep (2019) 39 (9): BSR20190489.

https://doi.org/10.1042/BSR20190489

Published: 03 September 2019

... and cells. High LUCAT1 expression was strongly associated with advanced stages and poor prognosis of TNBC. LUCAT1 contributed to TNBC development through accelerating cell proliferation, cell cycle progression and metastasis as well as attenuating cell apoptosis. Moreover, miR-5702 was proved to directly...

View articletitled, LncRNA LUCAT1 facilitates tumorigenesis and metastasis of triple-negative breast cancer through modulating miR-5702

Articles

MiR-16-5p inhibits breast cancer by reducing AKT3 to restrain NF-κB pathway

Liwei Ruan, Xiaojun Qian

Biosci Rep (2019) 39 (8): BSR20191611.

https://doi.org/10.1042/BSR20191611

Published: 23 August 2019

... © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . AKT3 breast cancer metastasis miRNA NF-κB As the most common tumor...

View articletitled, MiR-16-5p inhibits breast cancer by reducing AKT3 to restrain NF-κB pathway

Includes: Supplementary data

Articles

Overexpression of long noncoding RNA HOXB-AS3 indicates an unfavorable prognosis and promotes tumorigenesis in epithelial ovarian cancer via Wnt/β-catenin signaling pathway

Xiao-hong Zhuang, Ying liu, Jin-ling Li

Biosci Rep (2019) 39 (8): BSR20190906.

https://doi.org/10.1042/BSR20190906

Published: 02 August 2019

... 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . HOXB-AS3 Long noncoding RNA Metastasis Prognosis Proliferation Wnt/β-catenin...

View articletitled, Overexpression of long noncoding RNA HOXB-AS3 indicates an unfavorable prognosis and promotes tumorigenesis in epithelial ovarian cancer via Wnt/β-catenin signaling pathway

Articles

Dual-strand tumor suppressor miR-193b-3p and -5p inhibit malignant phenotypes of lung cancer by suppressing their common targets

Kyung Hee Choi, Chang Hoon Shin, Woo Joo Lee, Haein Ji, Hyeon Ho Kim

Biosci Rep (2019) 39 (7): BSR20190634.

https://doi.org/10.1042/BSR20190634

Published: 12 July 2019

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . AJUBA CCND1 HEG1 Lung cancer Metastasis microRNA-193b Despite the remarkable development of lung cancer therapies, lung cancer has been classified...

View articletitled, Dual-strand tumor suppressor miR-193b-3p and -5p inhibit malignant phenotypes of lung cancer by suppressing their common targets

Includes: Supplementary data

Articles

Establishment of a non-small-cell lung cancer-liver metastasis patient-derived tumor xenograft model for the evaluation of patient-tailored chemotherapy

Xue Yang, Gaopei Meng

Biosci Rep (2019) 39 (7): BSR20182082.

https://doi.org/10.1042/BSR20182082

Published: 05 July 2019

...Xue Yang; Gaopei Meng In order to optimize patient-tailored chemotherapy, a non-small-cell lung cancer (NSCLC)-liver metastasis patient-derived tumor xenograft (PDTX) model is developed. Computed tomography (CT)-guided NSCLC percutaneous biopsy was subcutaneously inoculated into the flank of non...

View articletitled, Establishment of a non-small-cell lung cancer-liver metastasis patient-derived tumor xenograft model for the evaluation of patient-tailored chemotherapy

Articles

miR-940 potentially promotes proliferation and metastasis of endometrial carcinoma through regulation of MRVI1

Zhan Zhou, Ya-Ping Xu, Li-Juan Wang, Yan Kong

Biosci Rep (2019) 39 (6): BSR20190077.

https://doi.org/10.1042/BSR20190077

Published: 10 June 2019

... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . endometrial carcinoma metastasis miR-940 MRVI1 proliferation Endometrial cancer (EC) is one of the most common reproductive system malignancies for females...

View articletitled, miR-940 potentially promotes proliferation and metastasis of endometrial carcinoma through regulation of MRVI1

Articles

Long non-coding RNA SPRY4-IT1 promotes epithelial–mesenchymal transition of cervical cancer by regulating the miR-101-3p/ZEB1 axis

Ming-Jun Fan, Yong-Hui Zou, Peng-Juan He, Shuai Zhang, Xiao-Mei Sun, Chang-Zhong Li

Biosci Rep (2019) 39 (6): BSR20181339.

https://doi.org/10.1042/BSR20181339

Published: 04 June 2019

... role in epithelial cancer progression and metastasis including cervical carcinoma, which have dramatic phenotypic changes by the loss of epithelial marker proteins such as E-cadherin and the acquisition of mesenchymal marker protein such as vimentin [ 6 , 7 ]. EMT is thought to be critical...

View articletitled, Long non-coding RNA SPRY4-IT1 promotes epithelial–mesenchymal transition of cervical cancer by regulating the miR-101-3p/ZEB1 axis

Includes: Supplementary data

Articles

Down-regulation of lncRNA-NEF indicates poor prognosis in intrahepatic cholangiocarcinoma

Zhanqiang Liang, Bingshuai Zhu, Dongdong Meng, Xiwen Shen, Xuemin Li, Zhongzhen Wang, Liantao Li

Biosci Rep (2019) 39 (5): BSR20181573.

https://doi.org/10.1042/BSR20181573

Published: 21 May 2019

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . intrahepatic cholangiocarcinoma lncRNA-NEF metastasis Runt-related transcription factor 1 (RUNX1) survival As a rare type of cholangiocarcinoma forms in the bile ducts, intrahepatic cholangiocarcinoma (IHCC...

View articletitled, Down-regulation of lncRNA-NEF indicates poor prognosis in intrahepatic cholangiocarcinoma

Articles

Relationship between microRNA-27a and efficacy of neoadjuvant chemotherapy in gastric cancer and its mechanism in gastric cancer cell growth and metastasis

Chunlei Xu, Hong Cheng, Na Li, Ning Zhou, Xushan Tang

Biosci Rep (2019) 39 (5): BSR20181175.

https://doi.org/10.1042/BSR20181175

Published: 21 May 2019

...Chunlei Xu; Hong Cheng; Na Li; Ning Zhou; Xushan Tang Objective: The aim of the present study is to investigate the relationship between microRNA-27a (miR-27a) and the efficacy of neoadjuvant chemotherapy in gastric cancer (GC) and its mechanism in the growth and metastasis of GC cells. Methods...

View articletitled, Relationship between microRNA-27a and efficacy of neoadjuvant chemotherapy in gastric cancer and its mechanism in gastric cancer cell growth and metastasis

Articles

UBE2C functions as a potential oncogene by enhancing cell proliferation, migration, invasion, and drug resistance in hepatocellular carcinoma cells

Yu Xiong, Jing Lu, Qinliang Fang, Yuyan Lu, Chengrong Xie, Huita Wu, Zhenyu Yin

Biosci Rep (2019) 39 (4): BSR20182384.

https://doi.org/10.1042/BSR20182384

Published: 17 April 2019

... . drug resistance growth metastasis sorafenib Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer-related mortality worldwide [ 1 ]. During the past two decades, the great advancement of HCC treatment has been achieved, including surgical...

View articletitled, UBE2C functions as a potential oncogene by enhancing cell proliferation, migration, invasion, and drug resistance in hepatocellular carcinoma cells

Articles

Chromatin target of protein arginine methyltransferase regulates invasion, chemoresistance, and stemness in epithelial ovarian cancer

Xiaojie Feng, Lei Li, Li Wang, Suxia Luo, Xupeng Bai

Biosci Rep (2019) 39 (4): BSR20190016.

https://doi.org/10.1042/BSR20190016

Published: 16 April 2019

... inhibiting the protein expressions of several transcriptional or surface markers of cancer stem cells. These findings first suggest that CHTOP, as a highly expressed protein in ovarian cancer, is closely associated with the malignant phenotypes of epithelial ovarian cancer cells, including metastasis...

View articletitled, Chromatin target of protein arginine methyltransferase regulates invasion, chemoresistance, and stemness in epithelial ovarian cancer

Includes: Supplementary data

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