... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . breast cancer DNA repair missense mutations molecular dynamics simulations NMR spectroscopy tumor suppressor gene Double-strand DNA breaks (DSBs) are severe lesions that introduce discontinuity...

... chemical shift perturbation experiments. budding yeast general transcription factor NMR spectroscopy PH domain TFIIH The general transcription factor TFIIH functions not only in transcription but also in DNA repair and cell cycle [ 1–3 ]. It consists of 10 subunits arranged in two...

... lines. In the present study, 1 H-NMR spectroscopy-based metabolic phenotyping was used to detect metabolic differences among five cancer cell lines, namely, lung (A549), colonic (Caco2), brain (H4), renal (RCC), and ovarian (SKOV3) cancer cells. The concentrations of choline, creatine, lactate, alanine...

... to determine how DM mechanistically contributes to brain disorders, such as AD and depression. However, available reviews focussing on brain metabolites in patients with diabetes is limited. biomarkers metabolite NMR spectroscopy neuroimaging type 2 diabetes Magnetic resonance spectroscopy...

... the metastatic and non-metastatic intratumoural oxygen levels was small (0.35% O 2 ), with a mean below 1.5% O 2 for most tumours. The metabolomic profiling, using NMR spectroscopy, of neuroblastoma cells cultured in normoxia or hypoxia for 3 days, and of the tumours formed by these cells showed that the effects...

... under the Creative Commons Attribution License 4.0 (CC BY) . covalent allostery high-throughput screen NMR spectroscopy protein-protein interactions X-ray crystallography Protein–protein interactions play crucial roles in many biological processes, both normal and pathological...

... 2017 The Author(s). 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Combined methods EPR spectroscopy NMR spectroscopy Protein spectroscopy structural...

...). 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioavailability catechin EGCG ITC NMR spectroscopy singular value decomposition...

... experiments of an early developmental oligodendroglial cell line (N19) that an MBP segment upstream of the primary ligand is involved in MBP–Fyn–SH3 association in cellula . Using solution NMR spectroscopy in vitro , we define this segment to comprise MBP residues (T62–L68), and demonstrate further...

... protein intein NMR spectroscopy protein folding Figure 1 Schematic representation of protein trans -splicing I N and I C represent the N- and C-terminal fragments of a split intein respectively. The two halves bind to each other non-covalently to initiate the splicing activity...

... structures in membrane environment has potential applications in rational drug design. Keywords Lipid-peptide interactions Æ Ligand docking Æ Induced conformation Æ Membrane-mimetic Æ Micelles Æ Bicelles Æ Membrane protein structure Æ Receptor-ligand interactions Æ NMR spectroscopy Æ GPCR activation Æ GPCR...