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Keywords: NOX1
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Articles

PGC-1α limits angiotensin II-induced rat vascular smooth muscle cells proliferation via attenuating NOX1-mediated generation of reactive oxygen species

Open Access
Qingbin Zhao, Junfang Zhang, Huifang Wang
Journal: Bioscience Reports
Biosci Rep (2015) 35 (5): e00252.
https://doi.org/10.1042/BSR20150112
Published: 29 September 2015
... that these mechanisms were not responsible for the observed effects of PGC-1α. However, we found that overexpression of PGC-1α promoted NOX1 degradation through the proteasome degradation pathway under AngII stimulation and consequently attenuated NOX1 (NADPH oxidase 1) expression. These alterations underlie...
View articletitled, PGC-1α limits angiotensin II-induced rat vascular smooth muscle cells proliferation via attenuating NOX1-mediated generation of reactive oxygen species
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Includes: Supplementary data