... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ADCY6 Alendronate MicroRNA-182 Osteoblasts Osteoporosis Rap1/MAPK...

... endocrinology. Therefore, it is of substantial significance to clarify the expression and function of miRNAs in bone endocrine physiology and pathology to improve the potential therapeutic value for metabolism-related bone diseases. We explored the effect of microRNA-182-5p (miR-182-5p) on osteoblast...

... recognized to mediate the onset or progression of DM. In the present study, we investigated the regulation on miR-223 level by AGE-BSA treatment in osteoblast-like MC3T3-E1 cells, with real-time quantitative PCR assay. And then we examined the inhibition of insulin-like growth factor 1 receptor (IGF-1R...

...E. Pérez; O. García-Martínez; M. Arroyo-Morales; C. Reyes-Botella; C. Ruiz Background/Aims Recent reports demonstrated that osteoblast-like cells can also exert activities directly associated with the immune system (cytokine synthesis, antigen presentation, phagocytosis and stimulation of T...

...O. García-Martínez; C. Reyes-Botella; O. Aguilera-Castillo; M.F. Vallecillo-Capilla; C. Ruiz The antigenic profile of human osteoblasts was previously analyzed by our group using primary cultures as study samples. These studies suggested a novel functional approach to this cell population...

... show that PTH causes a release of Ca 2+ from intracellular stores in a small percentage of osteosarcoma UMR 106-01 cells, and that PTH is capable of inducing an increase in cAMP-formation without affecting Ca i 2+ in osteoblasts. 3 2 1992 29 2 1992 © 1992 Plenum Publishing Corporation...

...Östen Ljunggren; Jan Rosenquist; Maria Ransjö; Ulf H. Lerner The effect of bradykinin on prostaglandin E 2 formation in cells from human trabecular bone has been studied. The cells responded to parathyroid hormone with enhanced cyclic AMP formation and were growing as cuboidal-shaped, osteoblast...