... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ADCY6 Alendronate MicroRNA-182 Osteoblasts Osteoporosis Rap1/MAPK...

...Huan Chen; Guowei Huang; Wei Mao; Peiliang He; Guodong Hou; Wencong Zhang; Zhiyi Liu; Aiguo Li; Shengnan Qin The occurrence and development of many diseases are highly associated with the aging of the body. Among them, osteoporosis (OP) is a common age-related disease that tends to occur...

...Ming Ming Liu; Rui Dong; Zhen Hua; Nan Ning Lv; Yong Ma; Gui Cheng Huang; Jian Cheng; Hai Yan Xu The effects of Liuwei Dihuang pill (LWDH) on diabetic nephropathy-related osteoporosis (DNOP) are unclear. The present study aimed to evaluate the effects of LWDH on KDM7A and Wnt/β-catenin signaling...

...Bin Chen; Wang-fa Zhu; Yi-yang Mu; Biao Liu; Hong-zhuo Li; Xiao-feng He Background: Many studies have reported the association between vitamin D receptor ( VDR ) polymorphism and osteoporosis risk. However, their results were conflicting. Six previous meta-analyses have been published to analyze...

...Ahu Soyocak; Merih Özgen; Didem Turgut Coşan; Hülyam Kurt; Fulya Doğaner; Onur Armağan; İrfan Değirmenci; Fezan Şahin Mutlu The present study was aimed to investigate the relationship between NOD1/CARD4 and NOD2/CARD15 gene polymorphisms and osteoporosis in the Turkish population. The first time we...

...Xi-Juan Zhang; Zhong-Hua Cui; Yan Dong; Xiu-Wen Liang; Yan-Xin Zhao; Ancha Baranova; Hongbao Cao; Ling Wang Osteoporosis (OP) is significant and debilitating comorbidity of chronic obstructive pulmonary disease (COPD). We hypothesize that genetic variance identified with OP may also play roles...

...Yu Feng; Lei Zhu; Yong Gu; Ling-Jun Wang; Bing-Jie Niu; Feng Cai; Liang Chen The Gremlin-2 (GREM2) plays crucial roles in modulating bone homeostasis through the bone morphogenetic protein-2 pathway. However, GREM2 gene variants in osteoporosis were less frequent in a Chinese population. Therefore...

... line of evidence to support that the PPP1CB gene involves in the etiology of osteoporosis. Correspondence: Jianwei Wang ( [email protected] ) * These authors contributed equally to this work. 16 09 2019 03 03 2020 03 04 2020 08 04 2020 © 2020 The Author(s...

... was to investigate the role of emodin in IBD-induced osteoporosis in an animal model. An IBD model in Sprague Dawley male rats was established by administering 2.5% dextran sulfate sodium (DSS) in the drinking water. Emodin was administered orally (30 mg/kg body weight) every other day starting in the third week...

... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bone E11/podoplanin osteoclast osteocyte osteoporosis Throughout life our skeleton is continuously remodeled, a process which is under...

... in osteoporosis (OP). Methods : Quantitative real-time PCR (qRT-PCR) was used to determine the expression of miR-128 in femoral neck trabecular bones of OP patients ( n =40) and non-OP patients ( n =40). C2C12 cells were transfected with miR-128 mimic or inhibitor to determine the effect of miR-128...

...Tuan-Mao Guo; Yan-Li Xing; Hai-Yun Zhu; Lan Yang; Guo-Xiong Liu; Xi-Min Qiao Postmenopausal osteoporosis is a common condition characterized by the increase and activation of osteoclasts. The present study aimed to investigate the effects of extracellular signal-regulated kinase (ERK) 5 (ERK-5...

...Yang Yang; Mengxue Fei; Xinying Zhou; Yuejun Li; Dadi Jin Objective: The present study was conducted for exploring the influence of fibroblast growth factor 2 receptor ( FGFR2 ) gene polymorphisms on osteoporosis occurrence risk in the Chinese population. Methods: Polymerase chain reaction...

...: However, little is known about the associations of these polymorphisms with susceptibility to osteoporosis, which we evaluated in this hospital-based case–control study involving 300 osteoporosis patients and 350 controls. Three single-nucleotide polymorphisms (SNPs) (rs183978373, rs12218, and rs10832915...

... risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals. Osteoporosis is the commonest metabolic bone disease characterized by low bone mass and microarchitectural deterioration of bone tissue, which leads to enhanced bone...

...Bao-Long Pan; Zong-Wu Tong; Shu-De Li; Ling Wu; Jun-Long Liao; Yu-Xi Yang; Hu-Huan Li; Yan-Juan Dai; Jun-E Li; Li Pan Osteoporosis (OP) is a serious health problem that contributes to osteoporotic structural damage and bone fragility. MicroRNAs (miRNAs) can exert important functions over bone...

...Hsing-Fang Lu; Henry Sung-Ching Wong; Ben-Kuen Chen; Hsien-Tzung Liao; Yu-Wen Hsu; Shiro Ikegawa; Er-Chieh Cho; Kuo-Sheng Hung; Wei-Chiao Chang Osteoporosis is defined by low bone mineral density (BMD), which is mainly due to the imbalances in osteoclast and osteoblast activity. Previous studies...

...Jun Min; Zhen Yuan; Qiao Zhang; Sijian Lin; Kai Wang; Jun Luo The aim of the present study was to clarify the effect of chlorogenic acid (CGA) on estrogen deficiency-induced osteoporosis based on micro-computed tomography (micro-CT) and potential mechanism of gene regulation via microarray...

...Qianyun Feng; Sheng Zheng; Jia Zheng Osteoporosis, a common and multifactorial disease, is influenced by genetic factors and environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet. Recently, emerging evidence suggests that epigenetic modifications may...

.... In the present study, we examined the effects of low-dose oestradiol (E2) combined with G15, a specific antagonist of GPR30 on ovariectomy (OVX)-induced osteoporosis in rats. Female Sprague–Dawley (SD) rats undergoing OVX were used to evaluate the osteoprotective effect of the drugs. Administration of E2 [35 μg...

...Feng Ruan; Qiang Zheng; Jinfu Wang Osteoporosis is a common disease in the elderly population. The progress of this disease results in the reduction of bone mass and can increase the incidence of fractures. Drugs presently used clinically can block the aggravation of this disease. However...