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Keywords: Oxidative stress
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Articles
Biosci Rep (2021) BSR20203091.
Published: 12 April 2021
... indicate that exposure to 20 µM HU caused significant oxidative stress and apoptosis of MII oocytes during maturation, which affected their developmental ability. These results provide valuable information for safety assessments of HU. * Corresponding Author; email: xianfeng79@jlu.edu.cn 08...
Articles
Biosci Rep (2021) 41 (3): BSR-20180861_EOC.
Published: 26 March 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis brain cadmium Fragaria ananassa oxidative stress The...
Articles
Biosci Rep (2021) 41 (2): BSR-20181414_EOC.
Published: 17 February 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Antioxidant Fibroblasts Neferine Oxidative stress Photoaging Ultraviolet...
Articles
Biosci Rep (2021) 41 (2): BSR20203955.
Published: 12 February 2021
... enrichment analysis were carried out by the Database for Annotation, Visualization and Integrated Discovery (DAVID) database. Furthermore, KGN cells were performed to validate the predicted results in oxidative stress (OS) model, and antioxidant effect was examined. Results: A total of 70 potential common...
Articles
Biosci Rep (2021) 41 (1): BSR20203219.
Published: 29 January 2021
...Zhenling Ma; Wenwen Zhang; Yaru Wu; Menghao Zhang; Lei Wang; Yihan Wang; Yi Wang; Wei Liu The excessive and inappropriate production of reactive oxygen species (ROS) can cause oxidative stress and is implicated in the pathogenesis of lung cancer. Cyclophilin A (CypA), a member of the immunophilin...
Articles
Biosci Rep (2020) 40 (10): BSR20201308.
Published: 30 October 2020
..., UCH-L1 inhibitor LDN-57444 suppressed mouse oocyte maturation by improving oxidative stress, attenuating mitochondrial function, curbing spindle body formation and down-regulating extracellular signal-related kinases (ERK1/2) expression, providing a deep insight into the cellular and molecular basis...
Articles
Biosci Rep (2020) 40 (10): BSR20201128.
Published: 16 October 2020
... agreement with CAUL. BYL-719 free radicals mitochondrial respiration oxidative stress phosphoinositide 3-kinase Mitochondria play a central role in coordinating cellular homoeostasis [ 1 ], and are putative mediators of health and disease, with mitochondrial dysfunction associated with the...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (10): BSR20194347.
Published: 14 October 2020
...Jinzi Zhou; Fenghua Chen; Aimin Yan; Xiaobo Xia Age-related macular degeneration (AMD) is a progressive and degenerative ocular disease associated with oxidative stress. Madecassoside (MADE) is a major bioactive triterpenoid saponin that possesses antioxidative activity. However, the role of MADE...
Articles
Biosci Rep (2020) 40 (8): BSR-20180515_EOC.
Published: 04 August 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cadmium oxidative stress antioxidant grape seed proanthocyanidins Nrf2/HO...
Articles
Biosci Rep (2020) BSR20200787.
Published: 20 July 2020
... improved cardiac dysfunction and hemodynamics, and attenuated cardiac fibrosis and hypertrophy via inhibiting oxidative stress in MI-induced HF rats. * Corresponding Author; email: 18906201122@189.cn 02 07 2020 16 03 2020 30 06 2020 Copyright 2020 The Author(s) 2020 This...
Articles
Biosci Rep (2020) 40 (7): BSR20193566.
Published: 17 July 2020
...Meng Zhang; Tai Zhang; Yanan Tang; Guiyun Ren; Yanning Zhang; Xiangyu Ren Ultraviolet (UV) radiation-induced photoaging is one of the contributors to skin aging. UV light triggers oxidative stress, producing a large number of matrix metalloproteinases (MMPs) and degrading the extracellular matrix...
Articles
Biosci Rep (2020) 40 (7): BSR20201812.
Published: 30 June 2020
.... Hemodynamic parameters including blood pressure and heart rate were measured. The histopathologic evaluation of kidney tissues was performed. Lactate, creatine kinase, inflammatory cytokines and oxidative stress indicators were determined. Using Seahorse analysis, the metabolic analysis of mitochondrial...
Articles
Biosci Rep (2020) 40 (6): BSR20200471.
Published: 17 June 2020
... (IκB and p65) and MAPK (JNK, ERK, and p38) signaling pathways. Similar alterations for oxidative stress and inflammation parameters were also detected in TNF-α-treated HaCaT cells. In addition, cimifugin-induced down-regulation of ICAM-1 were observed in TNF-α-treated cells. Altogether, our findings...
Articles
Biosci Rep (2020) 40 (5): BSR20193917.
Published: 20 May 2020
... oxidative stress recurrence superoxide dismutases Oxidative stress as a concept in redox biology and medicine had been formulated in 1985; at the beginning of 2015, approximately 138000 PubMed entries show for this term [ 1 ]. Oxidative stress is two-sided: whereas excessive oxidant challenge...
Articles
Biosci Rep (2020) 40 (4): BSR20194032.
Published: 17 April 2020
...Jin Yan; Disi Deng; Yeke Wu; Keming Wu; Jie Qu; Fei Li Disrupted follicular development may result in increased follicular atresia, which is a crucial mechanism of various ovarian pathologies. It has been demonstrated that oxidative stress is associated with disrupted follicular development...
Articles
Biosci Rep (2020) 40 (4): BSR20192133.
Published: 15 April 2020
... and cleaved caspase-3 expression, and up-regulate Bcl-Xl expression. Conclusion: Stigmasterol protects the brain from brain I/R damage by reducing oxidative stress and inflammation. Wistar rats were randomly divided into four groups: sham operation group, I/R model group, I/R model + stigmasterol...
Articles
Biosci Rep (2020) 40 (4): BSR20200040.
Published: 03 April 2020
... anions in the heart of MI rats and CFs with Ang II treatment. The results demonstrated that apelin-13 improved cardiac dysfunction, impaired cardiac hemodynamics, and attenuated fibrosis of CFs induced by Ang II via inhibiting the PI3K/Akt signaling pathway to inhibit oxidative stress. Apelin-13...
Articles
Biosci Rep (2020) 40 (4): BSR20193006.
Published: 31 March 2020
...Xiaomin Liu; Xiaowen Zhao; Rong Cheng; Yusen Huang Purpose: Autophagic dysfunction and abnormal oxidative stress are associated with cataract. The purpose of the present study was to investigate the changes of cellular autophagy and oxidative stress and their association in lens epithelial cells...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (2): BSR20191260.
Published: 18 February 2020
... were not statistically significant. Conclusion: Our results suggested that Wuling capsule ameliorated the depression in patients with T2DM, and also improved the state of inflammation and oxidative stress state. These results also strongly indicated the ability of clinical transformation of Wuling...
Articles
Biosci Rep (2020) 40 (2): BSR20193524.
Published: 07 February 2020
... oxycodone in cancer cells. Materials and Methods: Proliferation, survival and migration assays were performed on multiple types of cancer cells. Epithelial growth factor receptor (EGFR)/ERK/Akt pathway and oxidative stress were investigated after oxycodone treatment. Results: Oxycodone can either stimulate...
Articles
Biosci Rep (2020) 40 (1): BSR20193667.
Published: 29 January 2020
...Xiaoli Xu; Huimin Huang; Xiangyi Yin; Hongmei Fang; Xiaoyue Shen We aimed to investigate the regulatory mechanism of lentivirus-mediated overexpression of cystic fibrosis transmembrane conductance regulator (CFTR) in oxidative stress injury and inflammatory response in the lung tissue of mouse...
Articles
Biosci Rep (2020) 40 (1): BSR20191043.
Published: 24 January 2020
... Attribution License 4.0 (CC BY) . Inflammation Intestinal Ischemia/Reperfusion Injury Oxidative stress Ischemia/reperfusion (I/R) injury occurs in a tissue that undergoes a period of blood flow restriction followed by restoration [ 1 ]. The intestine is one of the organs that is most...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (12): BSR20193190.
Published: 23 December 2019
... death and cardiac dysfunction. Studies have shown that oxidative stress is an important mechanism for this maladaptation. Cyclophilin A (CyPA) is a member of the cyclophilin (CyPs) family. Many cells secrete CyPA to the outside of the cells in response to oxidative stress. CyPA from blood vessels and...
Articles
Biosci Rep (2019) 39 (11): BSR20192501.
Published: 13 November 2019
... License 4.0 (CC BY) . hepatic ischemia-reperfusion (I/R) injury hepatocytes Keap1/Nrf2/ARE signaling pathway oxidative stress reactive oxygen species (ROS) scutellarin Hepatic ischemia–reperfusion (I/R) injury is a commonly identified clinical complication that frequently occurs after...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (9): BSR20191711.
Published: 20 September 2019
... through inducing oxidative stress injury. The present study provides new knowledge on NP cell senescence and helps us to better understand the mechanism of disc degeneration. Correspondence: Haopeng Li ( doclihaopeng@163.com ) 27 05 2019 16 08 2019 23 08 2019 30 08 2019...
Articles
Biosci Rep (2019) 39 (8): BSR20191601.
Published: 28 August 2019
... Cryopreservation oxidative stress reactive oxygen species The ability to keep an organism alive while frozen and allowing it to survive for a prolonged period of time may sound like a scene lifted directly from a science fiction movie. Although freezing complex multicellular organisms remains challenging...
Articles
Biosci Rep (2019) 39 (8): BSR20190109.
Published: 19 August 2019
... apoptosis by inhibiting oxidative stress and activate the PI3K/Akt/caspase-3 signaling pathway via GLP-1R. Correspondence: Li Zhi-hong ( lizhihongmd@163.com ) 12 01 2019 04 07 2019 01 08 2019 05 08 2019 © 2019 The Author(s). 2019 This is an open access article published...
Articles
Biosci Rep (2019) 39 (8): BSR20190689.
Published: 15 August 2019
...Timin Ni; Wanju Yang; Yiqiao Xing Age-related macular degeneration (AMD) is now one of the leading causes of blindness in the elderly population and oxidative stress-induced damage to retinal pigment epithelial (RPE) cells occurs as part of the pathogenesis of AMD. In the present study, we...
Articles
Biosci Rep (2019) 39 (8): BSR20190788.
Published: 02 August 2019
..., oxidative stress, and inflammation. VR is commonly found in ischemic heart disease (IHD), hypertensive heart disease (HHD), diabetic cardiomyopathy (DCM), antineoplastic drug cardiotoxicity (CTX), and other CVDs. Therefore, we will review the relevant mechanisms of the miR-30 in VR induced by various...
Articles
Biosci Rep (2019) 39 (7): BSR20182297.
Published: 19 July 2019
... that OMT treatment could protect the integrity of the epithelial barrier, relieve oxidative stress, inhibit the expression of inflammatory mediators and pro-inflammatory cytokines, restrain the differentiation of Th17 cells and promote the differentiation of Treg cells via inhibition of the RhoA/ROCK...
Articles
Biosci Rep (2019) 39 (6): BSR20190166.
Published: 20 June 2019
... Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Postoperative cognitive dysfunction hip fracture malondialdehyde oxidative stress biomarker Postoperative cognitive dysfunction (POCD), a condition that has been poorly recognized and defined...
Articles
Biosci Rep (2019) 39 (5): BSR20190225.
Published: 21 May 2019
.... Inhibition of oxidative stress by N-acetylcysteine (NAC) reduced apoptosis and decreased ER stress in PA-treated H9c2 cells. Moreover, inhibition of ER stress by 4-phenyl butyric acid decreased apoptosis and attenuated oxidative stress. In summary, the present study demonstrated that oxidative stress...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (5): BSR20190112.
Published: 10 May 2019
...Junsheng He; Ailiang Zhang; Zhiwen Song; Shiwu Guo; Yuwei Chen; Zhiyuan Liu; Jinlong Zhang; Xu Xu; Jinbo Liu; Lei Chu Objective: The senescence of nucleus pulposus (NP) cells induced by oxidative stress is one of the important causes of intervertebral disc degeneration (IDD). Herein, we...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (4): BSR20182134.
Published: 30 April 2019
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . endothelial function oxidative stress p66Shc Proteins having Src homology 2 (SH2) domains participate in...
Articles
Biosci Rep (2019) 39 (2): BSR20170665.
Published: 15 February 2019
... function, serum insulin as well as in vivo oxidative stress biomarkers were assessed. BFBC shows highest antioxidants and α-amylase inhibitory activities in vitro . HFSTZ-induced T2D produced hyperglycemia ( P <0.05–0.001; F = 5.26–26.47), serum hyperinsulinemia (six-folds) plus elevated lipid...
Articles
Biosci Rep (2019) 39 (1): BSR20180787.
Published: 25 January 2019
.... Western blot analysis showed that SFI increased PPAR-γ expression; however, SFI treatment decreased cyclooxygenase-2 (COX-2) expression and the phosphorylation of NF-κBp65. Conclusions: These data demonstrated that SFI attenuated both inflammation and oxidative stress, and disrupted cholestatic liver...
Articles
Biosci Rep (2019) 39 (1): BSR20180515.
Published: 15 January 2019
...Nazima Bashir; Kalist Shagirtha; Vaikundam Manoharan; Selvaraj Miltonprabu The present study aims to evaluate the protective effect of grape seed proanthocyanidins (GSP) on cadmium (Cd)-induced testicular apoptosis, inflammation, and oxidative stress in rats. A total of 24 male Wistar rats were...
Articles
Biosci Rep (2018) 38 (6): BSR20181414.
Published: 14 December 2018
... protective effect of neferine against UV-A induced oxidative stress and photoaging in human dermal fibroblasts (HDFs). HDFs subjected to UV-A irradiation showed increased production of ROS and malondialdehyde (MDA). Furthermore, it depleted the cellular enzymatic antioxidant superoxide dismutase (SOD) and...
Articles
Biosci Rep (2018) 38 (6): BSR20181239.
Published: 23 November 2018
... (vehicle used to dissolve Apo) did not show differences in lung W/D ratio (Apo = 5.02 ± 0.7; EtOH = 4.8 ± 0.36) when compared with sham rats (5.25 ± 0.59) ( Figure 2 B). heart failure mechanotransduction nitric oxide synthase oxidative stress pulmonary edema Acute increases in left...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (6): BSR20180876.
Published: 21 November 2018
... the present study, the characteristics of mitophagy and the effects of rapamycin on contrast-induced abnormalities in oxidative stress, mitochondrial injury and mitophagy, TEC apoptosis and renal function were investigated in a CI-AKI rat model. Rats were divided into control group, CI-AKI group, and...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (6): BSR20180861.
Published: 16 November 2018
... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis brain cadmium Fragaria ananassa oxidative stress Cadmium (Cd) is one of the most toxic heavy metals and a common industrial pollutant present in the...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (5): BSR20180274.
Published: 12 September 2018
...Bo Kang; Xinxing Wang; Qilin Xu; Yongsheng Wu; Xiaohui Si; Dongmei Jiang The mechanism of action by which oxidative stress induces granulosa cell apoptosis, which plays a vital role in initiating follicular atresia, is not well understood. In the present study, the effect of 3-nitropropionic acid...
Articles
Biosci Rep (2018) 38 (5): BSR20180719.
Published: 07 September 2018
... =0.0449). ApoE does not function in protecting the brain from oxidative damage resulting from copper build-up in Wilson’s disease, but may play a role in regulating copper accumulation in the brain. We determined the oxidative stress through TBARS and SOD. The results showed that there were no...
Articles
Biosci Rep (2018) 38 (4): BSR20171003.
Published: 31 July 2018
.... Recent evidences have drawn the attention to its adverse effects on male reproductive system that include spermatogenesis defect, sperm count loss, and sperm maturation impairment. Fluoride induces oxidative stress through the activation of mitogen activated protein kinase (MAPK) cascade which can lead...
Articles
Biosci Rep (2018) 38 (4): BSR20180370.
Published: 03 July 2018
... access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . adult blood substitute fetal hemoglobin oxidative stress oxygen carrier The metHb (4 µM) was incubated with hemopexin...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (3): BSR20180308.
Published: 27 June 2018
... leads to the formation of oxidative stress parameters in proteins, carbohydrates, and DNA. In the present study, we aimed to show the effects of simvastatin on Galectin-3, and glutathione reductase (GR), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and thiobarbituric acid reactive...
Articles
Biosci Rep (2018) 38 (3): BSR20171522.
Published: 27 June 2018
...Qian Feng; Jing Hui; Na Tang; Yong-Min Liu; Hua Zhong; Zhen Li; La-Mei Wang; Yuan-Yuan Qu; Feng-Mei Deng; Fang He Human cytomegalovirus (HCMV) infection, chronic inflammation and oxidative stress, the renin–angiotensin system (RAS), endothelial function, and DNA methylation play roles in the...
Articles
Biosci Rep (2018) 38 (3): BSR20180282.
Published: 22 May 2018
...Naiyu Sun; Hong Zhang Pterygium is a common ocular disease characterized by proliferating fibrovascular tissue. Pyroptosis, a recently discovered programed cell death, is known to be associated with oxidative stress, one of the main causes of pterygia. Here, we aimed to study the role of pyroptosis...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (3): BSR20170939.
Published: 15 May 2018
... four groups: Non-AS, AS-mild, AS-moderate, and AS-severe groups; the levels of UA and oxidative stress-related factors in serum were detected. The middle cerebral artery occlusion (MCAO) model was used to stimulate CI in rats, and different doses of UA were administrated. The levels of oxidative stress...
Articles
Biosci Rep (2018) 38 (1): BSR20171611.
Published: 02 February 2018
... oxidative stress xanthorrhizol Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative disorder characterized by cognitive decline [ 1 , 2 ]. AD is also characterized morphologically by extensive amyloid deposition, neurofibrillary tangles, and neuroinflammation leading to...