... repair, transcriptional regulation, chromatin remodelling, vesicle trafficking, protein biosynthesis, cell death, and viral response [ 3-11 ]. Among the human ARTs, 17 are classified as PARPs (or ARTDs, for ADP-ribosyltransferases diphtheria toxin-like ), named PARP1-4, PARP6-16, and tankyrases 1 and 2...

... strategy using poly(ADP-ribose) polymerase (PARP) inhibitors in breast, ovarian, pancreatic, and prostate cancers. While PARP directed synthetic lethality has improved outcomes for many patients, the lack of sustained clinical response and the development of resistance pose significant clinical challenges...