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Keywords: PPP2R2A
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Biosci Rep (2019) 39 (7): BSR20190198.
Published: 10 July 2019
... for cisplatin increased from 3.65 to 8.73 μM. Thus, we report that miR-221 directly targets PP2A subunit B (PPP2R2A) in OS by binding to the 3′-UTR of the PPP2R2A mRNA. Restoration of PPP2R2A in miR-221-overexpressing OS cells recovers the cisplatin sensitivity of OS cells. Therefore, the present study suggests...
Includes: Supplementary data