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Keywords: SOCS2
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Articles
SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine
Open AccessKunlun Li, Lizeth G. Meza Guzman, Lachlan Whitehead, Evelyn Leong, Andrew Kueh, Warren S. Alexander, Nadia J. Kershaw, Jeffrey J. Babon, Karen Doggett, Sandra E. Nicholson
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (12): BSR20221683.
Published: 09 December 2022
.... Mice lacking SOCS2 display gigantism with increased body weight and length, and an enhanced response to GH treatment. Here, we characterized mice carrying a germ-line R96C mutation within the SOCS2-SH2 domain, which disrupts the ability of SOCS2 to interact with tyrosine-phosphorylated targets. Socs2...
Includes: Supplementary data
