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Keywords: Single nucleotide polymorphism
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Articles
Biosci Rep (2021) 41 (10): BSR20211865.
Published: 29 October 2021
... of diagnostic modalities available. The present study focuses on exploring more target genes with respective non-synonymous single nucleotide polymorphisms (nsSNPs) involved in the development of NSHL. The functional network analysis and variant study have successfully been carried out from the gene pool...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (7): BSR20210326.
Published: 06 July 2021
... environment, lifestyle, and genetics. Given the role of calcium signal transduction in several CVDs, we investigated via PCR-restriction fragment length polymorphism (RFLP) the single nucleotide polymorphism (SNP) rs7214723 within the calcium/calmodulin-dependent kinase kinase 1 ( CAMKK1 ) gene coding...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (11): BSR20200305.
Published: 24 November 2020
... to investigate the relationship between long noncoding RNA (lncRNA) materally expressed gene 3 ( MEG3 ) single nucleotide polymorphisms (SNPs) and the risk of gastric cancer and to construct a genetic-environmental risk assessment model. Methods: A case–control study was conducted to include 474 patients...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (8): BSR20191687.
Published: 11 August 2020
...Ben-gang Wang; Yi-zhi Li; Han-xi Ding; Zhi Lv; Qian Xu; Yuan Yuan Background: Non-coding RNA polymorphisms can affect disease risk and prognosis by influencing gene expression. Here, we first investigated the association between single nucleotide polymorphisms (SNPs) of long non-coding RNA (lncRNA...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (6): BSR20192999.
Published: 09 June 2020
.... A total of 2780 study subjects, including 884 hip OA cases and 1896 controls, were recruited. Nine tag single-nucleotide polymorphisms (SNPs) located within the LTBP3 gene region were selected for genotyping. Genetic association analyses were performed at both the genotypic and allelic levels. GTEx data...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (3): BSR20192429.
Published: 20 March 2020
...Rongbiao Ying; Zhiping Wei; Yuxian Mei; Shasha Chen; Liming Zhu Objective: To study the correlation between adenomatous polyposis coli ( APC ) gene 3′ untranslated region (UTR) single nucleotide polymorphisms (SNPs) and their interactions with environmental factors and the risk of colorectal cancer...
Articles
Biosci Rep (2019) 39 (11): BSR20191519.
Published: 13 November 2019
...Peiru Zhou; Yufei Xie; Zhimin Yan; Xiaosong Liu; Hong Hua Objectives: To investigate the association between dectin-1 gene single nucleotide polymorphisms (SNPs) and susceptibility to fungal infection (FI). Methods: Databases were searched electronically and manually to identify case–control...
Articles
Biosci Rep (2019) 39 (7): BSR20190708.
Published: 12 July 2019
...Ming-li Yang; Zhe Huang; Li-na Wu; Rong Wu; Han-xi Ding; Ben-gang Wang Background: Single-nucleotide polymorphisms (SNPs) in lncRNAs could be biomarkers for susceptibility to colorectal cancer (CRC), but the association of PCAT1 polymorphisms and CRC susceptibility is yet to be studied. Methods...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (6): BSR20181936.
Published: 20 June 2019
... single nucleotide polymorphism Lung cancer (LC) is the most common malignancy in the world and is a major cause of cancer-related deaths in developed countries [ 1 ]. Up to now, the overall survival rate of this disorder is still remarkedly poor. A host of studies have suggested that tobacco...
Articles
Biosci Rep (2019) 39 (5): BSR20190495.
Published: 15 May 2019
... BY) . case-control study colorectal cancer EGF Single nucleotide polymorphism Colorectal cancer (CRC) is the second leading cause of cancer deaths in Europe and the United States [ 1 ]. Previous data showed that 140,250 new cases of CRC were diagnosed in women and men, and 50,630 women and men...
Articles
Biosci Rep (2019) 39 (5): BSR20190292.
Published: 14 May 2019
... SNP was associated with plasma miR-24 levels. The RAB5B gene rs11550558, rs705700, rs11171718 SNPs were correlated with plasma miR-230 levels. Conclusion: The single nucleotide polymorphisms of the rs1045435, rs11550558, rs705700, and rs11171718 loci of the RAB5B gene are associated with PCOS risk...
Articles
Biosci Rep (2019) 39 (5): BSR20182232.
Published: 14 May 2019
...Liuping Zhang; Jinwei Liu; Peng Cheng; Fangchao Lv We aimed to study the relationship between rs11174811 and rs3803107 single nucleotide polymorphisms (SNPs) in miRNA target sites of the 3′ UTR in the arginine vasopressin receptor 1a gene ( AVPR1A ) and the risk of hypertension in the Chinese Han...
Articles
Biosci Rep (2019) 39 (5): BSR20182485.
Published: 02 May 2019
...Qiong Zhou; Lian Luo; Xiaohang Wang; Xiang Li Background and objective: Deregulation of the expression of amyloid precursor protein (APP) can lead to the development of Alzheimer’s disease (AD). Recent studies have shown that many single nucleotide polymorphisms (SNPs) in the 3′ untranslated region...
Articles
Biosci Rep (2019) 39 (3): BSR20182213.
Published: 19 March 2019
... association study (GWAS) had revealed single nucleotide polymorphism genes (SNPs) which were closely related with CAD risks. The relationship between long non-coding RNA (lncRNA) MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) and CAD risk is largely unknown. To our knowledge...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (2): BSR20182023.
Published: 27 February 2019
... BY) . knee osteoarthritis OPN single nucleotide polymorphism Osteoarthritis (OA), one of the most prevalent degenerative joint diseases, is a major cause of disability in the elderly worldwide. Approximately 10% of the world’s population (9.6% of males and 18% of females) aged over 60 years have...
Articles
Biosci Rep (2019) 39 (2): BSR20181987.
Published: 08 February 2019
... population. A total of 210 Chinese patients with ARDS were selected as the study group, 210 individuals who were identified as at-risk patients but did not meet criteria for ARDS were recruited as the control group. Three single nucleotide polymorphisms (SNPs) of IL-17, including rs763780 (A>G), rs2275913...
Articles
Biosci Rep (2019) 39 (2): BSR20181346.
Published: 01 February 2019
... access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Interleukin-6 Interleukin-8 Matrix metalloproteinase-13 Osteoarthritis Single nucleotide polymorphism Osteoarthritis (OA...
Articles
Biosci Rep (2019) 39 (1): BSR20181217.
Published: 25 January 2019
...Yunpeng Chen; Chenxi Ye; Jingwen Chen; Dongming Lin; Hao Wang; Shen Wang Objective: Genetic factors are involved in the occurrence, development, and progression of essential hypertension (EH). To study the association between single nucleotide polymorphisms (SNPs) of the rs6435156 and rs1048829...
Articles
Biosci Rep (2019) 39 (1): BSR20181505.
Published: 18 January 2019
...Jihang Chen; Zheping Hong; Chen Zhao; Qing Bi; Binsong Qiu The aim of the present study was to investigate the associations between single nucleotide polymorphisms (SNPs) in the PDZ and LIM domain protein 4 ( PDLIM4 ) gene and susceptibility to osteoporotic fracture in an elderly Han Chinese...
Articles
Biosci Rep (2019) 39 (1): BSR20181211.
Published: 03 January 2019
...Zhonghai Zhao; Bin Lv; Xiaodong Zhao; Yunlong Zhang Objective: To study the effects of single-nucleotide polymorphisms of the OPRM1 and ABCB1 genes on the analgesic effect and consumption of sufentanil after thoracoscopic-assisted radical resection of lung cancer. Methods: A total of 225 Chinese...
Articles
Biosci Rep (2019) 39 (1): BSR20181510.
Published: 03 January 2019
...Jing Zhang; Xiu-ling Liu; Qiao-wei Jia; Chen-hui Zhao; Jie-yin Liu; Feng-hui An; Li-hua Li; Zhao-hong Chen; Lian-sheng Wang; Wen-zhu Ma; Zhi-jian Yang; En-zhi Jia Objective : The aim of the present study is to investigate the association between the single nucleotide polymorphism (SNP) sites...
Articles
Biosci Rep (2018) 38 (6): BSR20181654.
Published: 18 December 2018
...-analysis Single Nucleotide Polymorphism SCN1A Valproic acid Resistance to antiepileptic drugs (AEDs) is crucial in epilepsy treatment. About 50–60% patients can be effectively treated by a single AED, the remaining being resistant to the treatment [ 1 ]. Genetic polymorphisms are assumed...
Articles
Biosci Rep (2018) 38 (6): BSR20181502.
Published: 18 December 2018
... BY) . coronary artery disease miR-130a Serum lipid Single nucleotide polymorphism Cardiovascular diseases (CVDs), particularly coronary heart disease, lead to major human morbidities and mortalities worldwide [ 1 ]. In 2015, data indicated that 422.7 (95% confidence interval (95% CI: 415.53–427.87...
Articles
Biosci Rep (2018) 38 (6): BSR20181481.
Published: 30 November 2018
... osteoporosis single nucleotide polymorphism Osteoporosis is a skeletal disorder characterized by low bone mineral density (BMD) that increases the risk of fracture [ 1 ]. Its prevalence among the elderly population in Taiwan is 24.15% in females and 11.03% in males [ 2 ]. Several factors contribute...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (6): BSR20180586.
Published: 21 November 2018
... 4.0 (CC BY) . Atherosclerosis Cerebral infarction Cathepsin S Single nucleotide polymorphism Cerebral infarction is a hypoxic and ischemic necrosis induced by insufficient blood supply of the local brain. It is caused by multiple factors, although atherosclerosis is the most common cause...
Articles
Biosci Rep (2018) 38 (5): BSR20171320.
Published: 17 October 2018
.... Nonetheless, the role of ET-1 ( EDN1 ) gene variants on coronary artery disease (CAD) risk remains poorly understood. The aim of the present study was to evaluate the role of EDN1 gene polymorphisms on individual susceptibility to CAD. We genotyped five tagSNPs (single-nucleotide polymorphisms) (rs6458155...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (5): BSR20180905.
Published: 02 October 2018
...Guangjun Jin; Zhu Chen; Jiancheng Zhang; Jia Song; Jun Shi; Bingzhi Zhou Objective: To examine the association between brain natriuretic peptide (BNP) gene single nucleotide polymorphisms (SNPs) and chronic obstructive pulmonary disease (COPD) and COPD with pulmonary hypertension (PH...
Articles
Biosci Rep (2018) 38 (5): BSR20180712.
Published: 25 September 2018
...Ben-Gang Wang; Li-Yue Jiang; Qian Xu MiRNA polymorphisms had potential to be biomarkers for hepatocellular cancer (HCC) susceptibility. Recently, miRNA single nucleotide polymorphisms (SNPs) were reported to be associated with HCC risk, but the results were inconsistent. We performed a systematic...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (5): BSR20181257.
Published: 19 September 2018
... Single Nucleotide Polymorphism Osteoarthritis (OA), the most common type of arthritis, could cause progressive loss of joint function [ 1 ]. OA is characterized by biochemical, morphological, molecular, and biomechanical changes in both extracellular matrix (ECM) and cells, which lead...
Articles
Biosci Rep (2018) 38 (5): BSR20171652.
Published: 05 September 2018
... of single nucleotide polymorphisms (SNPs) of lncRNA- H19 gene with the risk and prognosis of HCC. A total of 944 samples composed of 472 HCC patients and 472 matched controls were included in the risk analysis and amongst them 350 HCC samples were investigated in the prognosis analysis. KASP method...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (4): BSR20180273.
Published: 31 July 2018
... to be associated with various cancers, but the results were inconsistent. We performed a first-reported systematic review with a meta-analysis for the association of let-7 family single nucleotide polymorphisms (SNPs) with cancer risk/prognosis. Ten studies were included with a total of 3878 cancer cases and 4725...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (4): BSR20171627.
Published: 06 July 2018
... using a custom-by-design 48-Plex single nucleotide polymorphism Scan™ Kit. Our study indicated that IL-1α -899C/T polymorphism could increase the risk of IDD under the homozygous, recessive, and allelic models. Subsequently, we validated this significant association by a meta-analysis. Stratification...
Articles
Biosci Rep (2018) 38 (4): BSR20180749.
Published: 03 July 2018
... 2018 The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Kawasaki disease miRNA-146a single nucleotide polymorphism susceptibility...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (3): BSR20180324.
Published: 21 June 2018
...% CI: 1.015–1.823; P =0.042). The interaction between single nucleotide polymorphisms (SNP) of the rs987401919 and rs36071027 loci and smoking and drinking were distinctly associated with the incidence of CAD ( P <0.05). The content of systolic blood pressure (SBP), diastolic blood pressure (DBP...
Articles
Biosci Rep (2018) 38 (3): BSR20171670.
Published: 31 May 2018
...Lin Sun; Jun Ma; Qian Mao; Yun-Long Yang; Lin-Lin Ma; Ling Niu; Li-Feng Liu The present study was conducted to explore the correlations between single nucleotide polymorphisms (SNPs) in the calcium channel CACNA 1A, CACNA 1C, and CACNA 1H genes and diabetic peripheral neuropathy (DPN) amongst...
Articles
Biosci Rep (2018) 38 (2): BSR20171309.
Published: 09 March 2018
... HIF1A single nucleotide polymorphism Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease characterized by long-term poor airflow. COPD develops as a significant and chronic inflammatory response to inhaled irritants [ 1 ]. Although tobacco smoking is the most...
Articles
Biosci Rep (2018) 38 (1): BSR20171140.
Published: 02 February 2018
... of differentiation 14 Mannose-binding lectin Spinal tuberculosis Single nucleotide polymorphism Tumor necrosis factor- α Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB) [ 1 ]. An estimated 10.4 million people contracted TB in 2015, and it caused 1.8...
Articles
Biosci Rep (2017) 37 (2): BSR20160605.
Published: 27 March 2017
... C/T; rs2227956) by PCR-restriction fragment length polymorphism (RFLP). The ‘G’ allele of HSP70-2 (+1538 A/G) single nucleotide polymorphism (SNP) showed relative risk for normoalbuminuria, microalbuminuria and macroalbuminuria subjects whereas the ‘T’ allele of HSP70-hom (+2437 C/T) SNP showed...
Includes: Supplementary data