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Keywords: Survival
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Articles
Biosci Rep (2022) 42 (8): BSR20212835.
Published: 31 August 2022
... investigated by bioinformatic analyses. Results: A ferroptosis-related gene signature ( ALOX5, TFRC, PHKG2, FADS2, NOX1 ) was constructed using multivariate Cox regression analysis and represented as a risk score. Overall survival (OS) probability was significantly lower in the high-risk group than in the low...
Articles
Biosci Rep (2022) 42 (6): BSR20220465.
Published: 27 June 2022
... ( P =0.027). Patients harboring C>A somatic mutation were more likely to develop relapse (52.6% vs. 26.5%, P =0.003), have poor survival (57.9% vs. 27.7%, P =0.001), and have shorter disease-free survival (43.2 ± 2.6 months vs. 56.8 ± 1.29 months, P <0.001) and overall survival (49.6 ± 2.4...
Articles
Biosci Rep (2022) 42 (4): BSR20212685.
Published: 19 April 2022
... with increasing histological grades of this malignancy. PTMA immunostaining also displayed a strong positive association with the MIB-1 index. Univariate analysis revealed a superior prognostic value of PTMA to predict overall survival (OS) as compared with the routinely used markers (p53, isocitrate...
Includes: Supplementary data
Articles
Biosci Rep (2022) 42 (1): BSR-2021-1103_COR.
Published: 06 January 2022
... Survival The authors of the original article “CDKN2A is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma.” ( Biosci Rep (2021) 41 (10), https://doi.org/10.1042/BSR20211103 ) would like to correct Table 2 . Due to their negligence, they had switched...
Articles
Biosci Rep (2021) 41 (10): BSR20211103.
Published: 06 October 2021
... with CDKN2A expression and immune invasion with the risk of developing HCC. A totally of 2207 different genes were found between HCC and adjacent liver tissues from TCGA and GEO databases. CDKN2A was highly expressed in HCC and associated with poorer overall survival and disease-free survival. Notably, CDKN2A...
Articles
Biosci Rep (2021) 41 (8): BSR20203531.
Published: 05 August 2021
... and the result showed that the positive OPN expression group had a lower overall survival than the negative expression group (univariate: hazards ratio (HR) = 2.32, 95% confidence interval (95% CI) [1.74, 3.10], multivariate: HR = 2.41, 95% CI [1.63, 3.57]) and a lower biochemical relapse-free survival than...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (6): BSR20204370.
Published: 04 June 2021
... ]. The Kaplan–Meier plotter database is capable to assess the effect of 54 k genes on survival in 21 cancer types, including breast cancer, ovarian cancer, lung cancer, and gastric cancer. In addition, LUAD patients obtained from TCGA database were divided into the high expression group and the low expression...
Articles
Biosci Rep (2021) 41 (5): BSR20210478.
Published: 06 May 2021
... receptors denoted longer progression-free survival (PFS), overall survival (OS), and platinum-free interval (PFI). Platinum-sensitive patients had higher expression of hormone receptors than their counterparts. Correlation analysis revealed significant positive correlations between hormone receptors...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (4): BSR20204136.
Published: 22 April 2021
... controls to assess the association of genetic polymorphisms in miR-143/145 and the KRAS 3′ untranslated region (3′UTR) with susceptibility to CRC and patients’ survival. In addition, genetic variations of genomic regions located from 500 bp upstream to 500 bp downstream of the miR-143/miR-145 gene...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (4): BSR20204456.
Published: 09 April 2021
...-radiotherapy, immunotherapy, etc. The limited number of treatments contributed to little progress, with a flat 5-year survival rate [ 3 , 4 ]. Significantly, up to 25% of new diagnosed cases present as muscle-invasive or advanced stage (T2-T4),with a very poor prognosis [ 5 ]. Therefore, it is meaningful...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (3): BSR20204006.
Published: 15 March 2021
... were used to map the box and bubble plots. The difference in survival between the high-risk and the low-risk groups was assessed by the Kaplan–Meier method and compared using the log-rank test. A one-way analysis of variance (ANOVA) followed by a Newman–Keuls post-hoc test was used for comparisons...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (11): BSR20203263.
Published: 13 November 2020
... for overall survival was validated with both TCGA and ICGC cohorts. The 1-, 3- and 5-year ROC curves were plotted, in which the AUC was 0.842, 0.726 and 0.699 in TCGA cohort and 0.734, 0.691 and 0.700 in ICGC cohort, respectively. Moreover, the expression levels of the five genes were determined in clinical...
Articles
Biosci Rep (2020) 40 (8): BSR20201427.
Published: 13 August 2020
... the prognosis for survival have been discovered through bioinformatics analysis. However, the prediction of disease prognosis using a single gene is not an accurate method. In the present study, a mechanistic model was established to achieve better prediction for the prognosis of COAD. COAD-related data...
Articles
Biosci Rep (2020) 40 (7): BSR20200442.
Published: 30 June 2020
... because of its guiding significance on the therapy strategies. Methods: In this work, we analyzed the relationship between gene expression and HNSCC in The Cancer Genome Atlas (TCGA) cohort, and optimized the panel with random forest survival analysis. Subsequently, a Cox multivariate regression-based...
Articles
Biosci Rep (2020) 40 (7): BSR20194240.
Published: 30 June 2020
.... The bioinformatic analysis was performed on the data of 374 cancer tissues and 50 normal tissues, which were downloaded from TCGA database. We observed that 17 differentially expressed IRGs were significantly associated with survival in LIHC patients. These LIHC-specific IRGs were validated with function analysis...
Articles
Biosci Rep (2020) 40 (6): BSR20192690.
Published: 16 June 2020
...Rong-Rui Huo; Xu Liu; Jing Cui; Liang Ma; Kun-Hua Huang; Cai-Yi He; Yang Yang; Xue-Mei You; Wei-Ping Yuan; Bang-De Xiang; Jian-Hong Zhong; Le-Qun Li Background and aim: Assessing the average survival rate of patients with hepatocellular carcinoma (HCC) after hepatectomy is important for making...
Articles
Biosci Rep (2020) 40 (4): BSR20200459.
Published: 17 April 2020
.... Relevant studies were systematically searched in the Cochrane Library, EMBASE, and PubMed until June 27, 2019. Eligible studies were validated for the prognostic effect of PD-L1 on the overall survival (OS), disease-free survival (DFS), and relapse-free survival (RFS) in HCC using a hazard ratio (HR...
Articles
Biosci Rep (2020) 40 (4): BSR20200520.
Published: 15 April 2020
...Gang Wu; Xinghui Song; Jun Liu; Shize Li; Weiqin Gao; Mingxing Qiu; Changjin Yang; Yiming Ma; Yuhong Chen Background: Higher tumor expression of CD44, a marker of cancer stem cells (CSCs), is associated with poor overall survival (OS) in various cancers. However, the association between CD44...
Articles
Biosci Rep (2020) 40 (2): BSR20193794.
Published: 07 February 2020
...-regulated in CSCC and predicted poor survival. The expression levels of MCM3AP-AS1 were inversely correlated with the expression levels of miR-93. Overexpression of MCM3AP-AS1 led to down-regulation of miR-93, while silencing of MCM3AP-AS1 played an opposite role in CSCC cells. Methylation-specific PCR...
Articles
Biosci Rep (2020) 40 (1): BSR20193379.
Published: 14 January 2020
...Xin Guan; Chao Liu; Tianshuo Zhou; Zhigang Ma; Chunhui Zhang; Bojun Wang; Yang Yao; Xiaona Fan; Zhiwei Li; Yanqiao Zhang The aim of the present study was to investigate the survival and prognostic factors of patients who were with advanced esophageal squamous cell carcinoma (ESCC) and developed...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (7): BSR20190615.
Published: 05 July 2019
... migration and invasion. hepatocellular carcinoma lncRNA SAMMSON miR-9-3p survival Figure 1 SAMMSON was up-regulated in HCC tissues but was not affected by HBV and HCV infections Expression data compared by performing paired t test showed that, comparing with non-cancer tissues...
Articles
Biosci Rep (2019) 39 (5): BSR20181573.
Published: 21 May 2019
... healthy controls. Patients were followed up for 5 years, patients with high plasma levels of lncRNA-NEF showed significantly better survival conditions compared with patients with low expression levels of lncRNA-NEF. LncRNA-NEF overexpression led to inhibited expression of RUNX1 in cells of IHCC cell...
Articles
Biosci Rep (2019) 39 (5): BSR20190363.
Published: 21 May 2019
... pairs of clinical tissues from patients were collected for circLMTK2 expression investigation. Afterward, the relationship of circLMTK2 expression level and clinical features, such as survival, tumor size and so on, were analyzed, along with a multivariate Cox hazards analysis. Finally, malignant...
Articles
Biosci Rep (2019) 39 (5): BSR20181640.
Published: 07 May 2019
...-regulation was significantly associated with worse overall survival (OS) and disease-free survival (DFS) in HCC patients (Log rank P =0.00583 and P =4.178E-04, respectively). Cox analysis revealed that FAM83D high expression was significantly associated with OS in HCC patients [hazard ratio (HR) = 1.44, 95...
Articles
Biosci Rep (2019) 39 (4): BSR20190251.
Published: 30 April 2019
... found that CASC11 was up-regulated, while miR-188-5p was down-regulated in tumor tissues of HCC patients. CASC11 and miR-188-5p were not affected by HBV and HCV infections. Follow-up study showed that high levels of CASC11 were significantly correlated with poor survival. Expression levels of CASC11...
Articles
Biosci Rep (2019) 39 (3): BSR20181426.
Published: 19 March 2019
..., associations between TSC gene variants and survival of cancer patients treated with platinum-based chemotherapy were not evaluated. Genetic variants of TSC1 and TSC2 were identified by next-generation sequencing and selected for further clinical evaluation based on predetermined criteria. Associations...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (6): BSR20181178.
Published: 07 December 2018
... reported the prognostic values of GINS subunits in HCC patients through analysis of several databases, including Oncomine, (TCGA), and Kaplan–Meier Plotter (KMPlotter). We found that mRNA expressions of all GINS subunits were significantly up-regulated in HCC tumor than in non-tumor liver tissues. Survival...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (6): BSR20181528.
Published: 21 November 2018
... the prognosis of HNSCC. Three lncRNAs are identified to be significantly associated with survival in the training dataset using Cox regression analysis. Three lncRNAs were integrated to construct an lncRNA expression signature that could stratify patients of training dataset into the high-risk group and low...
Articles
Biosci Rep (2018) 38 (6): BSR20180752.
Published: 07 November 2018
...Minjie Tian; Wenying Ma; Yueqiu Chen; Yue Yu; Donglin Zhu; Jingping Shi; Yingdong Zhang Background: Preclinical models have suggested a role for sex hormones in the development of glioblastoma multiforme (GBM). However, the impact of gender on the survival time of patients with GBM has not been...
Articles
Biosci Rep (2016) 36 (6): e00424.
Published: 09 December 2016
... functional role in breast cancer has not been well characterized. In the present study, SIN1 is associated with the progression and survival of breast cancer patients, as well as human breast cancer cell proliferation and migration. SIN1 mRNA level was significantly up-regulated in human breast cancer...
Articles
Biosci Rep (2015) 35 (1): e00175.
Published: 25 February 2015
... in the expression of anti-apoptotic Bcl2 (B-cell lymphoma 2) protein and other pro-survival genes like cyclin D1 (cyc D1), survivin and hTERT (human telomerase reverse transcriptase). Concomitantly, E2 + TNF-α combination increased the survival of SiHa cells by positive changes in viability, proliferation...
Includes: Supplementary data
Articles
Biosci Rep (1994) 14 (4): 189–204.
Published: 01 August 1994
...Jacques Falciola; Bernard Volet; Rolf M. Anner; Marlis Moosmayer; Danielle Lacotte; Beatrice M. Anner Lymphocytes are primordial immune cells with variable life times. Besides genetic programming, extracellular factors interacting with cell surface receptors might alter cell survival. We...
Articles
Biosci Rep (1989) 9 (1): 119–127.
Published: 01 February 1989
... and protection against neurotoxins. This paper shows that the effect of gangliosides is not restricted to neurons. The monosialoganglioside GM 1 efficiently increases the survival of thymocytes and protects them against both the lytic effect of the glucocorticoid prednisolone and the effect of a thymocytotoxic...