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Articles
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (05): BSR20241389.
Published: 13 May 2025
Includes: Supplementary data
Images
in Modulating adipose-derived stromal cells' secretomes by culture conditions: effects on angiogenesis, collagen deposition, and immunomodulation
> Bioscience Reports
Published: 13 May 2025
Figure 1: Human perirenal adipose-derived stromal cell (h-prASC) secretomes enhance human umbilical vein endothelial cell (HUVEC) angiogenic capacity. ( A-F ) Representative images of tube formation with HUVEC exposed to the various h-prASC secretomes for 20 hours. Scale bar, 100 µm. Exposure to ... More about this image found in Human perirenal adipose-derived stromal cell (h-prASC) secretomes enhance h...
Images
in Modulating adipose-derived stromal cells' secretomes by culture conditions: effects on angiogenesis, collagen deposition, and immunomodulation
> Bioscience Reports
Published: 13 May 2025
Figure 2: Rat perirenal adipose-derived stromal cell (r-prASC) secretomes enhance rat aortic endothelial cell (RAEC) angiogenic capacity. ( A-F ) Representative images of tube formation with RAEC exposed to the various r-prASC secretomes for 20 hours. Scale bar, 100 µm. Exposure to ( A ) standard... More about this image found in Rat perirenal adipose-derived stromal cell (r-prASC) secretomes enhance rat...
Images
in Modulating adipose-derived stromal cells' secretomes by culture conditions: effects on angiogenesis, collagen deposition, and immunomodulation
> Bioscience Reports
Published: 13 May 2025
Figure 3: Human perirenal adipose-derived stromal cell (h-prASC) secretomes stimulate collagen secretion by human fibroblasts. ( A-F ) Representative images of Picrosirius red staining in human fibroblasts exposed to various h-prASC secretomes for 72 hours. Scale bar, 50 µm. Exposure to ( A ) sta... More about this image found in Human perirenal adipose-derived stromal cell (h-prASC) secretomes stimulate...
Images
in Modulating adipose-derived stromal cells' secretomes by culture conditions: effects on angiogenesis, collagen deposition, and immunomodulation
> Bioscience Reports
Published: 13 May 2025
Figure 4: Rat perirenal adipose-derived stromal cell (r-prASC) secretomes stimulate collagen secretion by rat fibroblasts. ( A ) ( A−F ) Representative images of Picrosirius-red staining in rat fibroblasts exposed to various r-prASC secretomes for 72 hours. Scale bar, 50 µm. Exposure to ( A ) sta... More about this image found in Rat perirenal adipose-derived stromal cell (r-prASC) secretomes stimulate c...
Images
in Modulating adipose-derived stromal cells' secretomes by culture conditions: effects on angiogenesis, collagen deposition, and immunomodulation
> Bioscience Reports
Published: 13 May 2025
Figure 5: Human perirenal adipose-derived stromal cell (h-prASC) secretomes modulate antibody-mediated immune responses. The effect of various h-prASC secretomes on humoral alloimmunity was evaluated using a mixed lymphocyte reaction (MLR) followed by an antibody-mediated complement-dependent cyt... More about this image found in Human perirenal adipose-derived stromal cell (h-prASC) secretomes modulate ...
Images
in Modulating adipose-derived stromal cells' secretomes by culture conditions: effects on angiogenesis, collagen deposition, and immunomodulation
> Bioscience Reports
Published: 13 May 2025
Figure 6: Rat perirenal adipose-derived stromal cell (r-prASC) secretomes modulate antibody-mediated immune responses. The effect of various r-prASC secretomes on humoral alloimmunity was evaluated using a MLR followed by an antibody-mediated complement-dependent cytotoxicity (CDC) assay. The out... More about this image found in Rat perirenal adipose-derived stromal cell (r-prASC) secretomes modulate an...
Articles
Potential role of polydatin in treating diabetes mellitus and diabetes-related chronic complications
Open Access
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (05): BSR20241307.
Published: 13 May 2025
Images
in Potential role of polydatin in treating diabetes mellitus and diabetes-related chronic complications
> Bioscience Reports
Published: 13 May 2025
Figure 1: The effects of polydatin on glucose and lipid metabolism. Abbreviations: ACC, acetyl-CoA carboxylase; AMPK, AMP-activated protein kinase; FA, fatty acid; G6Pase, glucose 6-phosphatase; GCK, glucokinase; GSK-3β, glycogen synthase kinase-3 beta; IRS-1/2, insulin receptor substrate-1 or 2;... More about this image found in The effects of polydatin on glucose and lipid metabolism. Abbreviations: A...
Images
in Potential role of polydatin in treating diabetes mellitus and diabetes-related chronic complications
> Bioscience Reports
Published: 13 May 2025
Figure 2: Nephroprotective actions of polydatin. Abbreviations: AP-1, activator protein-1; ARE, antioxidant response element; Cx32, connexin 32; HO-1, heme oxygenase-1; ICAM-1, intercellular adhesion molecule-1; Keap1, Kelch-like ECH associated-protein 1; NF-κB, nuclear factor kappa B; Nrf2, nucl... More about this image found in Nephroprotective actions of polydatin. Abbreviations: AP-1, activator prot...
Images
in Potential role of polydatin in treating diabetes mellitus and diabetes-related chronic complications
> Bioscience Reports
Published: 13 May 2025
Figure 3: Protective effects of polydatin against a wide range of diabetic complications. Created in BioRender. Tang, K. (2025) https://BioRender.com/f61o708 . More about this image found in Protective effects of polydatin against a wide range of diabetic complicati...
Articles
Articles
Toward safer and sustainable food preservation: a comprehensive review of bacteriocins in the food industry
Open Access
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (04): 277–302.
Published: 17 April 2025
Images
in Toward safer and sustainable food preservation: a comprehensive review of bacteriocins in the food industry
> Bioscience Reports
Published: 17 April 2025
Figure 1: Schematic representation of lantibiotic biosynthesis, maturation, antimicrobial action, and self-immunity mechanisms in the producer cell. The biosynthetic process begins with gene cluster transcription and precursor peptide synthesis, which includes an N-terminal leader peptide prevent... More about this image found in Schematic representation of lantibiotic biosynthesis, maturation, antimicro...
Images
in Toward safer and sustainable food preservation: a comprehensive review of bacteriocins in the food industry
> Bioscience Reports
Published: 17 April 2025
Figure 2: Guide for the evaluation and approval of new bacteriocins for food applications. A diagram is presented illustrating the essential steps for evaluating and approving new bacteriocins intended for use in food applications. More about this image found in Guide for the evaluation and approval of new bacteriocins for food applicat...
Articles
Images
Published: 11 April 2025
Figure 1: Phylogenetic analysis of UDP-glucose pyrophosphorylases (UGPases) from different organisms. Yellow background, UGPases from plants. Blue background, UGPases from fungi. Red background, UGPases from animals. Green background, UGPases from bacteria E. coli . Multiple sequence alignment w... More about this image found in Phylogenetic analysis of UDP-glucose pyrophosphorylases (UGPases) from diff...
Images
Published: 11 April 2025
Figure 2: The purified UGPases and specific activity of UGPase from different organisms. ( A ) SDS-PAGE (12% gel) analysis of the purified UGPases from different organisms. M, protein marker; marker ladders are in kDa. ( B ) The specific activity of UGPases. The biological triplicates were perfor... More about this image found in The purified UGPases and specific activity of UGPase from different organis...
Images
Published: 11 April 2025
Figure 3: Temperature and pH optima of various UDP-glucose pyrophosphorylases (UGPases). ( A ) Temperature optima. The highest activity for each UGPase at a specific temperature is defined as 100%. ( B ) pH optima. The highest activity for each UGPase at a specific pH is defined as 100%. The biol... More about this image found in Temperature and pH optima of various UDP-glucose pyrophosphorylases (UGPase...
Images
Published: 11 April 2025
Figure 4: Thermal stability of recombinant UGPases. ( A ) EcUGP; ( B ) ScUGP; ( C ) AnUGP; ( D ) HvUGP; ( E ) AtUGP; ( F ) StUGP; ( G ) MeUGP; ( H ) IbUGP; ( I ) ZmUGP; ( J ) DmUGP; ( K ) HsUGP. The recombinant UGPases were incubated in the MOPS-KOH buffer (50 mM, pH 7.0) at 37°C, 50°C, 60°C, and... More about this image found in Thermal stability of recombinant UGPases. ( A ) EcUGP; ( B ) ScUGP; ( C ) ...
Images
Published: 11 April 2025
Figure 5: The substrate preferences of recombinant UDP-glucose pyrophosphorylases (UGPases). ( A ) The preference of sugar phosphates Glc1P, Gla1P, GlcA1P, and GlcNAc1P. The highest UGPase activity was measured when using Glc1P as a substrate, which is defined as 100%. ( B ) The preference of nuc... More about this image found in The substrate preferences of recombinant UDP-glucose pyrophosphorylases (UG...
Images
Published: 11 April 2025
Figure 6: The kinetic curves of recombinant UGPases. The kinetic curves of recombinant UGPases toward substrate Glc1P. ( A ) EcUGP; ( B ) ScUGP; ( C ) AnUGP; ( D ) HvUGP; ( E ) AtUGP; ( F ) StUGP; ( G ) MeUGP; ( H ) IbUGP; ( I ) ZmUGP; ( J ) DmUGP; ( K ) HsUGP. An, A. niger ; At, A. thaliana ; ... More about this image found in The kinetic curves of recombinant UGPases. The kinetic curves of recombina...
Articles
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (04): 247–262.
Published: 09 April 2025
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (04): 233–245.
Published: 09 April 2025
Includes: Supplementary data
Images
Published: 09 April 2025
Figure 1: Plot of the correlation between phenotypic allostatic load and the epigenetic signature in the SKIPOGH cohort. ( A ). The correlation between AL-GP (the phenotype-based score) and the methAL signature. ( B ). The correlation between AL-GP and the HM-450K compatible methALT signature, st... More about this image found in Plot of the correlation between phenotypic allostatic load and the epigenet...
Images
Published: 09 April 2025
Figure 2: Plot of odds ratios and 95% confidence intervals for probability of history of cardiovascular disease corresponding to different measures of allostatic load. Odds ratios and 95% confidence intervals for the association between measures of AL and a history of cardiovascular disease. Pres... More about this image found in Plot of odds ratios and 95% confidence intervals for probability of history...
Images
Published: 09 April 2025
Figure 3: Association between methALT and the risk of mortality in the LBC1936 cohort over time. The solid black line represents the hazard ratio (HR) of the association between the methALT signature and risk of mortality with increasing time since study entry. HRs correspond to the standardized ... More about this image found in Association between methALT and the risk of mortality in the LBC1936 cohort...
Images
Published: 09 April 2025
Figure 4: Risk of mortality according to the method used to measure allostatic load in the LBC1936 cohort. Filled-in circles represent the point estimate, while the solid lines correspond to the 95% confidence interval. All presented hazard ratios correspond to the standardized signature/score. L... More about this image found in Risk of mortality according to the method used to measure allostatic load i...
Images
in The final proteolytic step in transmembrane signaling of multiple RsgI anti-σ factors in Clostridium thermocellum
> Bioscience Reports
Published: 09 April 2025
Figure 1: The domain organization of SigI and nine RsgI factors in C. thermocellum DSM1313. SigI contains an N-terminal domain (SigIN) and a C-terminal domain (SigIC), responsible for recognizing the promoter -10 and -35 elements, respectively. Each RsgI contains an N-terminal intracellular dom... More about this image found in The domain organization of SigI and nine RsgI factors in C. thermocellum ...
Images
in The final proteolytic step in transmembrane signaling of multiple RsgI anti-σ factors in Clostridium thermocellum
> Bioscience Reports
Published: 09 April 2025
Figure 2: Model of transmembrane signal transduction of RsgI in C. thermocellum . The first step of the signal transduction is the autocleavage of the periplasmic domain (PD) of RsgI and the β1 separation from the PD. The second step is the cleavage in the membrane by the protease RseP. The fina... More about this image found in Model of transmembrane signal transduction of RsgI in C. thermocellum . T...
Images
in The final proteolytic step in transmembrane signaling of multiple RsgI anti-σ factors in Clostridium thermocellum
> Bioscience Reports
Published: 09 April 2025
Figure 3: The transmembrane region of nine RsgI factors and the domain organization of four unfoldases in C. thermocellum DSM1313. ( A ) Sequence alignment of the transmembrane helix regions of the RsgIs in C. thermocellum DSM1313. The transmembrane helices predicted by the TMHMM program are ... More about this image found in The transmembrane region of nine RsgI factors and the domain organization o...
Images
in The final proteolytic step in transmembrane signaling of multiple RsgI anti-σ factors in Clostridium thermocellum
> Bioscience Reports
Published: 09 April 2025
Figure 4: Purified RsgI-NFs. (A ) SDS-PAGE of the eight purified RsgI-NFs samples. The expected RsgI-NF bands are indicated by red arrows. ( B ) Western blot analysis of the eight purified RsgI-NFs using the anti-His6-tag antibodies. More about this image found in Purified RsgI-NFs. (A ) SDS-PAGE of the eight purified RsgI-NFs samples. ...
Images
in The final proteolytic step in transmembrane signaling of multiple RsgI anti-σ factors in Clostridium thermocellum
> Bioscience Reports
Published: 09 April 2025
Figure 5: ClpEP, ClpCP, ClpXP, and ClpAP protease assays for RsgI-NFs. 0: before reaction, 40: after 40 min of reaction at 50°C. The bands of RsgI-NFs are indicated by red dashed rectangles. The bands of unfoldases are indicated by black arrows. ( A–H ) ClpEP, ClpCP, and ClpXP protease assays for... More about this image found in ClpEP, ClpCP, ClpXP, and ClpAP protease assays for RsgI-NFs. 0: before rea...
Images
in The final proteolytic step in transmembrane signaling of multiple RsgI anti-σ factors in Clostridium thermocellum
> Bioscience Reports
Published: 09 April 2025
Figure 6: ClpEP, ClpCP, and ClpXP protease assays for RsgI6-NF(1–57aa) and RsgI6-NF(1–70aa). The bands of unfoldases are indicated by black arrows. 0: before reaction, 40: after 40 min of reaction at 50°C. More about this image found in ClpEP, ClpCP, and ClpXP protease assays for RsgI6-NF(1–57aa) and RsgI6-NF(1...
Images
in The final proteolytic step in transmembrane signaling of multiple RsgI anti-σ factors in Clostridium thermocellum
> Bioscience Reports
Published: 09 April 2025
Figure 7: The recognition of multiple and extended XAA sites in RsgI-NFs by ClpXP. The bands of unfoldases are indicated by black arrows. ( A ) ClpX protease assays of RsgI1-NFs and RsgI8-NFs truncated at different XAA motifs in the transmembrane region. ( B ) Protease assay of RsgI2-NF-FAAAAA. More about this image found in The recognition of multiple and extended XAA sites in RsgI-NFs by ClpXP. T...
Images
in The final proteolytic step in transmembrane signaling of multiple RsgI anti-σ factors in Clostridium thermocellum
> Bioscience Reports
Published: 09 April 2025
Figure 8: ClpEP, ClpCP, ClpXP, and ClpAP protease assays for RsgI6NTD-RsgI2TM-NF and RsgI6NTD-RsgI9TM-NF. The bands of unfoldases are indicated by black arrows. 0: before reaction, 40: after 40 min of reaction at 50°C. More about this image found in ClpEP, ClpCP, ClpXP, and ClpAP protease assays for RsgI6NTD-RsgI2TM-NF and ...
Articles
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (04): 215–231.
Published: 02 April 2025
Includes: Supplementary data
Images
in Identification and functional validation of ACSL1 as a biomarker regulating ferroptosis in nucleus pulposus cell
> Bioscience Reports
Published: 02 April 2025
Figure 1: Diagram describing the research methods used in the study. More about this image found in Diagram describing the research methods used in the study.
Images
in Identification and functional validation of ACSL1 as a biomarker regulating ferroptosis in nucleus pulposus cell
> Bioscience Reports
Published: 02 April 2025
Figure 2: Identification of significant modules using WGCNA and construction of weighted co-expression network. ( A ) Genetic tree diagram. ( B ) Clustering dendrogram depicting clinical data from 16 samples. ( C,D ) Exploring scale-free fit index and mean connectivity across different soft-thres... More about this image found in Identification of significant modules using WGCNA and construction of weigh...
Images
in Identification and functional validation of ACSL1 as a biomarker regulating ferroptosis in nucleus pulposus cell
> Bioscience Reports
Published: 02 April 2025
Figure 3: Functional enrichment analysis of MEs. ( A–C ) GO analysis of biological processes ( A ), cellular components ( B ), and molecular functions ( C ). ( D ) KEGG enrichment analysis of the MEs. ( E,F ) Metascape analysis. GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; ME... More about this image found in Functional enrichment analysis of MEs. ( A–C ) GO analysis of biological p...
Images
in Identification and functional validation of ACSL1 as a biomarker regulating ferroptosis in nucleus pulposus cell
> Bioscience Reports
Published: 02 April 2025
Figure 4: DEGs were associated with immune response. ( A ) Volcano plot depicting DEGs, among which ACSL1 is up-regulated in IVDD samples. ( B ) GO enrichment analysis of DEGs. ( C ) KEGG enrichment analysis of DEGs. ( D,E ) GO and KEGG combined functional enrichment analysis of up-regulated ( ... More about this image found in DEGs were associated with immune response. ( A ) Volcano plot depicting DE...
Images
in Identification and functional validation of ACSL1 as a biomarker regulating ferroptosis in nucleus pulposus cell
> Bioscience Reports
Published: 02 April 2025
Figure 5: Immunological landscape of degenerative intervertebral disc. ( A ) The stacked bar chart illustrates the immune cell infiltration across different samples. ( B ) Comparison of immune cell infiltration profiles between intervertebral disc degeneration and healthy samples across 28 differ... More about this image found in Immunological landscape of degenerative intervertebral disc. ( A ) The sta...
Images
in Identification and functional validation of ACSL1 as a biomarker regulating ferroptosis in nucleus pulposus cell
> Bioscience Reports
Published: 02 April 2025
Figure 6: Identification of six hub genes in IVDD samples. ( A ) Venn diagram shows the intersection between DEGs, MEs from WGCNA, and ferroptosis-related genes. ( B ) Chromosomal co-ordinates of the six hub genes. ( C ) Diagnostic receiver operating characteristic analysis of six hub genes. ( D ... More about this image found in Identification of six hub genes in IVDD samples. ( A ) Venn diagram shows ...
Images
in Identification and functional validation of ACSL1 as a biomarker regulating ferroptosis in nucleus pulposus cell
> Bioscience Reports
Published: 02 April 2025
Figure 7: Identification of ACSL1 as a biomarker of intervertebral disc degeneration. ( A ) Heat map shows the relationship between the expression level of hub genes and infiltration level of different immune cells. ( B ) Relative expression level of the hub genes between different immune subty... More about this image found in Identification of ACSL1 as a biomarker of intervertebral disc degeneratio...
Images
in Identification and functional validation of ACSL1 as a biomarker regulating ferroptosis in nucleus pulposus cell
> Bioscience Reports
Published: 02 April 2025
Figure 8: Validation of ACSL1 changes in IL-1β-induced degenerative NP cell. ( A ) IC 50 of IL-1β on NP cells. ( B–D ) Fe 2+ concentration, MDA level and GSH level in different groups. ( E ) Immunofluorescent staining showed ROS level in IL-1β-treated group and control group (scale bar: 20 μm... More about this image found in Validation of ACSL1 changes in IL-1β-induced degenerative NP cell. ( A )...
Images
in Identification and functional validation of ACSL1 as a biomarker regulating ferroptosis in nucleus pulposus cell
> Bioscience Reports
Published: 02 April 2025
Figure 9: Knockdown of ACSL1 ameliorates ferroptosis in degenerative NP cells. ( A,B ) The interfering efficiency of ACSL1 in NP cells was evaluated by RT-qPCR and western blot. ( C–E ) The intracellular Fe 2+ concentration, MDA, and GSH levels of NP cells in different groups. ( F ) Cell via... More about this image found in Knockdown of ACSL1 ameliorates ferroptosis in degenerative NP cells. ( A...
Images
in Identification and functional validation of ACSL1 as a biomarker regulating ferroptosis in nucleus pulposus cell
> Bioscience Reports
Published: 02 April 2025
Figure 10: ACSL1 elevation in IVDD rat model. ( A ) H&E staining and SO/FG staining of rat disc tissue. ( B–E ) The western blot result revealed that the expression of ACSL1 was increased in IVDD rats, while SLC7A11 and GPX4 were decreased. ( F ) RT-qPCR revealed that ACSL1 mRNA elevate... More about this image found in ACSL1 elevation in IVDD rat model. ( A ) H&E staining and SO/FG stain...
Articles
Articles
Articles
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