... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Aconitase Ferric reductase Iron metabolism Iron-sulfur Monothiol glutaredoxins Suppressor mutation Organisms have evolved sophisticated mechanisms to maintain iron homeostasis [ 1 , 2 ]. Extensive work in the budding...

.... © 1997 Plenum Publishing Corporation 1997 Reactive oxygen species mitochondria pore apoptosis uncoupling non-coupled respiration aconitase Bioscience Reports, Vol. 17, No. 3, 1997 REVIEW Membrane-Linked Systems Preventing Superoxide Formation Vladimir P. Skulachev Received January 17...

...Paul R. Gardner O −2 produced by the autoxidation of respiratory chain electron carriers, and other cellular reductants, inactivates bacterial and mammalian iron-sulfur-containing (de)hydratases including the citric acid cycle enzyme aconitase. Release of the solvent-exposed iron atom and oxidation...