... was aimed to investigate the protective effect and mechanisms of Pun on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. Methods and Results: Forty-eight BALB/c male mice were used to establish ALI by intratracheal-instilled 2.4 mg/kg LPS, the mice were randomly divided into model and Pun...

...Jiaxin Xu; Dan Xu; Zhizhong Yu; Zhaohui Fu; Zheng Lv; Lei Meng; Xin Zhao Background: Acute lung injury (ALI) is a respiratory disease with high morbidity and mortality rates. Currently, there is no effective treatment to complement mechanical ventilation. Exosomes and microRNAs (miRNAs...

... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . acute lung injury apoptosis inflammation PPARγ PTEN/β-catenin pathway sepsis ...

...Wuquan Li; Wentao Zhang; Jun Liu; Yalong Han; He Jiang; Gang Ji; Wenjun Liu Excessive pulmonary inflammatory response is critical in the development of acute lung injury (ALI). Previously, microRNAs (miRNAs) have been recognized as an important regulator of inflammation in various diseases. However...

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . sepsis acute lung injury PPARγ PTEN/β-catenin pathway apoptosis...

...Lili Liu; Junyi Chen; Xiaofang Zhang; Xue Cui; Nana Qiao; Yun Zhang; Jie Yang The present study aims to reveal the molecular mechanism of peroxisome proliferator-activated receptor γ (PPARγ) on sepsis-induced acute lung injury (ALI). To do that, the rat injury model was established using cecal...

...Yafeng Liang; Jiaqi Luo; Nengli Yang; Shufen Wang; Mingwei Ye; Guoquan Pan Acute lung injury (ALI) is a lethal disease with diffuse lung inflammation, in which JAK/STAT3 signaling has been well recognized for its role in initiating and amplifying inflammatory processes. However, the mechanism...

...Shuiqiao Fu; Weina Lu; Wenqiao Yu; Jun Hu Background: To study the protective effect of Cordyceps sinensis extract (Dong Chong Xia Cao in Chinese [DCXC]) on experimental acute lung injury (ALI) mice. Methods and results: ALI model was induced by intratracheal-instilled lipopolysaccharide (LPS, 2.4...

...Tao Qiu; Jiangqiao Zhou; Tianyu Wang; Zhongbao Chen; Xiaoxiong Ma; Long Zhang; Jilin Zou Acute lung injury (ALI) is an acute inflammatory disease. Leukocyte immunoglobulin-like receptor B4 (LILRB4) is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing inhibitory receptor...

...Juan Wang; Yong-Chun Shen; Zhen-Ni Chen; Zhi-Cheng Yuan; Hao Wang; Da-Jiang Li; Kai Liu; Fu-Qiang Wen Long non-coding RNAs (lncRNAs) are involved in various biological processes as well as many respiratory diseases, while the role of lncRNAs in acute lung injury (ALI) remains unclear. The present...

... 02 09 2018 12 09 2018 14 09 2018 © 2018 The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . acute lung injury liver...

... been reported to be found in the lungs. NMDAR is activated in acute lung injury (ALI). Here, the present experiment was designed to examine whether NMDAR blockade (MK-801) ameliorates ALI through affecting neuropeptides in LPS-induced sepsis animal models. Male Kunming mice were divided into control...

...Hui-Lun Lu; Xin-Yan Huang; Yi-Feng Luo; Wei-Ping Tan; Pei-Fen Chen; Yu-Biao Guo The goal of the present study was to investigate the role of M1 macrophages in acute lung injury (ALI). To address this, we used lipopolysaccharide (LPS)-treated wild-type and CD11b-DTR mice, and examined their M1...