...Kaichuan He; Bo Tan; Ao Lu; Lu Bai; Chengqing Song; Yuxin Miao; Biyu Liu; Qian Chen; Xu Teng; Jing Dai; Yuming Wu Aging is an inevitable and irreversible biological process that gradually heightens the risks of various diseases and death. As a newly discovered endogenous gasotransmitter, hydrogen...

...Anna E. Stanhewicz; Kelsey S. Schwartz; Ruda Lee Worldwide, pregnancy at age 35 or older, termed ‘advanced maternal age (AMA)’, is increasing exponentially. As the incidence of pregnancy at AMA has increased, a growing body of evidence has suggested that AMA is also associated with increased risk...

... microenvironment. aging amyloid Cancer glioma neurodegeneration proteostasis Figure 3 Key genetic mutations in brain tumors Cancers are always an outcome of multiple gene mutations. Some mutations are common for different cancers and some are specific to cancer types. Common genetic mutations...

...Huan Chen; Guowei Huang; Wei Mao; Peiliang He; Guodong Hou; Wencong Zhang; Zhiyi Liu; Aiguo Li; Shengnan Qin The occurrence and development of many diseases are highly associated with the aging of the body. Among them, osteoporosis (OP) is a common age-related disease that tends to occur...

... insights into the underlying mechanisms of endothelial senescence and potential therapeutic targets of ASCVD as well as other age-related diseases. 29 07 2021 21 12 2021 22 12 2021 04 01 2022 © 2022 The Author(s). 2022 This is an open access article published by Portland Press...

...Amy E. Morgan; Katie D. Acutt; Mark T. Mc Auley There is a growing need for biomarkers which predict age-onset pathology. Although this is challenging, the methylome offers significant potential. Cancer is associated with the hypermethylation of many gene promoters, among which are developmental...

...Shi-zhong Cai; Li-na Zhao; Jun Liu; Yi-ting Ji; Xiao-yan Shi; Zhou-rui Ma; Xiao-hua Lv; Ke Chen; Yan Chen Hematopoietic stem cells (HSCs) aging is associated with hematopoietic dysfunction and diseases. Our previous study showed that lead exposure induced a functional decline in HSCs. Allicin...

...E. Scott Sills; Samuel H. Wood In clinical infertility practice, one intractable problem is low (or absent) ovarian reserve which in turn reflects the natural oocyte depletion associated with advancing maternal age. The number of available eggs has been generally thought to be finite and strictly...

...Jun-Jie Yuan; Qin Zhang; Chang-Xiong Gong; Fa-Xiang Wang; Jia-Cheng Huang; Guo-Qiang Yang; Liang Liu; Kai Zhou; Rui Xu; Qiong Chen; Yu Zhou; Xiao-Yi Xiong; Qing-Wu Yang Aging has been shown to contribute to both the declined biofunctions of aging brain and aggravation of acute brain damage...

... survive within survival niches in an antigen-independent manner. Despite this, the phenotype of adaptive immune cells changes with aging, and BM niches themselves are affected, leading to impaired long-term maintenance of immunological memory in the elderly as a result. Oxidative stress, age-related...

...Abdullah Kaplan; Andriy Yabluchanskiy; Rana Ghali; Raffaele Altara; George W. Booz; Fouad A. Zouein Heart failure is associated with low cardiac output (CO) and low brain perfusion that imposes a significant risk for accelerated brain ageing and Alzheimer’s disease (AD) development. Although...

...Mark T. Mc Auley; Alvaro Martinez Guimera; David Hodgson; Neil Mcdonald; Kathleen M. Mooney; Amy E. Morgan; Carole J. Proctor The aging process is driven at the cellular level by random molecular damage that slowly accumulates with age. Although cells possess mechanisms to repair or remove damage...

... be implicated in the regulation of cancer cell energy metabolism. However, at this point any role of DBC1 in cancer is only speculative. In this review, we will discuss the new developments in DBC1 research, its molecular structure, regulatory roles and implication in metabolism, aging and cancer. 1...

.... CR (calorie restriction) has been shown to delay the onset of several age-related diseases and extend mean and maximum lifespan in a variety of species [ 1 ]. Although the beneficial effects of CR are well demonstrated, the underlying mechanisms are not entirely clear. The membrane theory of aging...

...Luis Rodriguez-Menocal; Si M. Pham; Dania Mateu; Melissa St-Pierre; Yuntao Wei; Ivo Pestana; Abdelouahab Aitouche; Roberto I. Vazquez-Padron Alteration of VSMC (vascular smooth-muscle cell) physiology is associated with the development of atherosclerosis and restenosis. We hypothesize that aging up...

... and expressed as μmol/min per mg of protein. Controls, filled bars; CR mice, open bars. Comparisons between CR and control mice: ¶ P <0.001 old CR versus old control. Comparisons between age groups on similar diets: a P <0.003 old control versus young control; b P <0.001 old CR versus young CR; c...

... has a similar effect on mice of the control strain, but this is less pronounced due to the non-accelerated character of their senescence processes. © 1999 Plenum Publishing Corporation 1999 Carnosine oxidative stress aging senescence accelerated mice (SAM) Bioscience Reports, Vol. 19...

... disease, such as mitochondrial encephalomyopathy and aging occur in these organisms. Recent developments of the Human Genome Project will become an important factor in the study of mammalian bioenergetics. To elucidate the physiological roles of human F 0 F 1 , genes encoding the subunits of F 0 F 1 were...

...Alessandro Lentini; Laura Falasca; Francesco Autuori; Luciana Dini We studied the simultaneous binding of galactose and mannose-exposing ligands in sinusoidal rat liver cells during development and aging. The galactose-specific receptors were visualized using 17 nm diameter colloidal gold particles...

...-arabinoside rat thymus involution aging DNA-methylation Bioscience Reports, Vol. 6, No. 7, 1986 Thymus Involution Induced by 5-Azacytidine Adam Csordas 1 and Konrad Schauenstein 2 Received June 26, 1986 KEY WORDS: 5-azacytidine; cytosine-arabinoside, rat thymus, involution, aging, DNA-methytation...