... total RNA, and 1.25 μg antibody with 0.1 μg total RNA. By comparing the m 6 A peak calling, enriched motifs, alternative splicing events, and nuclear transcripts modified by m 6 A between the CST and Millipore libraries, it was found that the CST library presented similar data to Millipore, even...

... may be structured and show how novel RNA structures may influence RNA processing including splicing and polyadenylation. RNA structures can be targeted therapeutically to treat disease. alternative splicing polyadenylation precursor RNA RNA structure splicing transcription...

...Dan Sun; Xingping Zhao; Yang Yu; Waixing Li; Pan Gu; Zhifu Zhi; Dabao Xu Background: Ovarian cancer (OV) is a serious threat to women’s health. Immunotherapy is a new approach. Alternative splicing (AS) of messenger RNA (mRNA) and its regulation are highly relevant for understanding every cancer...

...Biyu Zhang; Lei Yang; Xin Wang; Denggang Fu Aberrant RNA alternative splicing (AS) variants play critical roles in tumorigenesis and prognosis in human cancers. Here, we conducted a comprehensive profiling of aberrant AS events in acute myeloid leukemia (AML). RNA AS profile, including seven...

...Yidi Wang; Yaxuan Wang; Kenan Li; Yabing Du; Kang Cui; Pu Yu; Tengfei Zhang; Hong Liu; Wang Ma Alternative splicing (AS), an essential process for the maturation of mRNAs, is involved in tumorigenesis and tumor progression, including angiogenesis, apoptosis, and metastasis. AS changes can...

... of cancer deaths worldwide. Its high-frequency metastasis and relapse rate lead to the poor survival of HCC patients. However, the mechanism of HCC metastasis is still unclear. Alternative splicing events (ASEs) have a great effect in cancer development, progression and metastasis. We downloaded RNA...

... and endothelial dysfunction. The soluble protein is an alternative splice variant of FLT1, which also encodes for the full-length receptor Flt-1. The mechanism of the alternative splicing, and the reason for its inappropriate increase in preeclampsia, is not well understood. U2 auxiliary factor 65 (U2AF65...

... transition (EMT) of pneumocytes has been implicated as a factor. Herein, we aimed to explore the underlying mechanisms of lung fibrosis mediated by EMT, with a focus on the alternative splicing of fibroblast growth factor receptor 2 (FGFR2), using bleomycin (BLM)-induced lung fibrotic and transgenic mouse...

... and histone mRNA degradation. Here, we report the accumulation of alternatively spliced HBP/SLBP transcripts lacking exons 2 and/or 3 in HeLa cells exposed to replication stress. We also detected a shorter HBP/SLBP protein isoform under these conditions that can be accounted for by alternative splicing of HBP...

... alternative splicing variants ( DHRS4A _ v1 – 6 ) (AY920361, AY920362, DN237886, DN237887, DN237890 and DN237892 respectively), resulted from alternative splicing. DHRS4A1 and DHRS4A2 were specifically transcribed in neuroblastoma cells. RNA structural analysis of DHRS4A1 and DHRS4A2 suggested...

...-type pumps alternative splicing PMCA4 Bioscience Reports, Vol. 16, No. 2, 1996 REVIEW The Targeting of the Plasma Membrane Calcium Pump in the Cell Dani lo Guerini I and Ernesto Carafoli 2'3 Received January 4, 1996 The information on the structural determinants hat control the cellular...