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Journal: Bioscience Reports
Biosci Rep (2018) 38 (1): BSR20171148.
Published: 10 January 2018
... the synthesis of various thiamine antimetabolites such as amprolium, pyrithiamine, oxythiamine, or 3-deazathiamine. Results of biochemical and theoretical chemistry research show that affinity to thiamine diphosphate-dependent enzymes of these synthetic molecules exceeds the affinity of native...