... [ 20 ] AD, PD, CJD, Prion-associated diseases Insulin amyloid 80 µM In vitro 4, 10, and 24 h ↑ Amyloid degradation Girigoswami et al. , 2019 [ 33 ] AD, PD, Prion-associated diseases HEWL amyloid 10 µM In vitro 120 h ↓ Amyloid fibrillation Ban et al. , 2016 [ 34 ] PD 6-OHDA (50...

...Shalini Singh; Vibhuti Joshi; Arun Upadhyay Amyloids are high-order proteinaceous formations deposited in both intra- and extracellular spaces. These aggregates have tendencies to deregulate cellular physiology in multiple ways; for example, altered metabolism, mitochondrial dysfunctions, immune...

... (PMDs) and involves human islet amyloid polypeptide (hIAPP) misfolding and accumulating in parts of the body, primarily in the pancreas, causing damage to islet cells and affecting glucose regulation. In this review, we have summarised our current understanding of what causes hIAPP to misfold, what...

... concentration. Cofactors such as glycosaminoglycans and metal ions have been found associated with amyloid deposits in vivo and shown to affect protein assembly kinetics in vitro. Cofactor interactions with the amyloidogenic process are an area of great interest for therapeutic intervention for the wide range...

... that is defined by four sequence motifs and a highly conserved tertiary structure. A common structure–function relationship for this domain is hitherto unknown. A characteristic of several CAP proteins is their formation of amyloid-like structures in the presence of lipids. Here we investigate the structural...

...Alexandr G. Bobylev; Oxana V. Galzitskaya; Roman S. Fadeev; Liya G. Bobyleva; Darya A. Yurshenas; Nikolay V. Molochkov; Nikita V. Dovidchenko; Olga M. Selivanova; Nikita V. Penkov; Zoya A. Podlubnaya; Ivan M. Vikhlyantsev Amyloids are insoluble fibrous protein aggregates, and their accumulation...

..., the CTD (C-terminal domain) and the core domain (p53C) that constitutes the sequence-specific DBD (DNA-binding region). Most p53 mutations related to cancer development are found in the DBD. Aggregation of p53 into amyloid oligomers and fibrils has been shown. Moreover, amyloid aggregates of both...