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Keywords: angiogenesis
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Biosci Rep (2021) 41 (4): BSR20204442.
Published: 07 April 2021
...Dengliang Lei; Yue Chen; Yang Zhou; Gangli Hu; Fang Luo Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers worldwide. Neovascularization is closely related to the malignancy of tumors. We constructed a signature of angiogenesis-related long noncoding RNA (lncRNA) to...
Includes: Supplementary data
Biosci Rep (2020) 40 (10): BSR20202130.
Published: 14 October 2020
..., Occludin and claudin 1 (CLND1). In conclusion, these findings suggested that Tim-3 may exert a positive role in angiogenesis and a negative role in TJ formation in vascular endothelial cells, which may provide novel strategies for the treatment of Tim-3-associated diseases. Correspondence: Yuxin Cui...
Biosci Rep (2020) 40 (5): BSR20193256.
Published: 05 May 2020
... study, we constructed a DR animal model and a model in HRMECs to investigate the relationship between p38 and RUNX1 in retinal micro-angiogenesis in diabetic retinopathy. We found that p38 could promote retinal micro-angiogenesis by up-regulating RUNX1 expression in diabetic retinopathy. This suggested...
Biosci Rep (2019) 39 (10): BSR20191006.
Published: 15 October 2019
... ( zqx26@163.com ) 25 04 2019 17 09 2019 25 09 2019 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . angiogenesis...
Biosci Rep (2019) 39 (7): BSR20190513.
Published: 10 July 2019
...Chang Dai; Qiaoyun Gong; Yan Cheng; Guanfang Su Roundabout4 (Robo4) is a transmembrane receptor that belongs to the Roundabout (Robo) family of axon guidance molecules. Robo4 is an endothelial-specific receptor that participates in endothelial cell migration, proliferation, and angiogenesis and the...
Biosci Rep (2019) 39 (5): BSR20190155.
Published: 02 May 2019
...Cai Hai-rong; Huang Xiang; Zhang Xiao-rong Angiogenesis is a vital step during the process of oncogenesis of a lot of tumors, with no exception in bladder cancer. One of the useful strategies for the development of new drugs against cancer is targeting angiogenesis. In the present study, we found...
Biosci Rep (2019) 39 (2): BSR20181776.
Published: 26 February 2019
... significant infiltration of macrophage antigen-2 (Mac-2) positive macrophages by secreting monocyte chemoattractant protein-1 (MCP-1) at the early stage of suction. Subsequently, these infiltrated macrophages expressed massive vascular endothelial growth factor (VEGF) to promoted angiogenesis. Conclusion: EVE...
Includes: Supplementary data
Biosci Rep (2019) 39 (2): BSR20181260.
Published: 15 February 2019
...). It has been recently linked to suppress precancerous lesion and tumor development. The current study sought to explore the role of YHD on trans-endothelium and angiogenesis of BC. Methods: HER2+ BC cells were treated with YHD, Trastuzumab, or the combination in vitro and in vivo to compare the...
Includes: Supplementary data
Biosci Rep (2019) 39 (1): BSR20181804.
Published: 25 January 2019
...Qian Jiang; Li Cheng; Daiyuan Ma; Yanli Zhao Lung cancer is the leading cause of cancer-related mortality worldwide, characterized by uncontrolled proliferation and metastasis of lung cancer cells. Tumor angiogenesis plays a key role in proliferation and metastasis in cancers, and is an essential...
Includes: Supplementary data
Biosci Rep (2019) 39 (1): BSR20181218.
Published: 08 January 2019
... sensitive biomarkers and key regulators in the development of atherosclerosis. However, the biological functions and molecular regulatory mechanisms for miR-575 on angiogenesis remain unknown. In our study, we first identified up-regulation of circulating miR-575 in plasma of essential hypertensive patients...
Biosci Rep (2018) 38 (6): BSR20180882.
Published: 16 November 2018
... mechanism during GC pathogenesis. angiogenesis feedback NBAT1 Sox9 A genome-wide association study identifies a susceptibility locus to clinically aggressive neuroblastoma at 6p22 [ 8 ]. Recently, lncRNA neuroblastoma associated transcript 1 (NBAT1), transcribed from the intron of chromosome...
Includes: Supplementary data
Biosci Rep (2018) 38 (5): BSR20181493.
Published: 31 October 2018
... the Creative Commons Attribution License 4.0 (CC BY) . ANGPTL4 angiogenesis inflammation ocular diseases vascular permeability We would like to thank Guerra et al. [ 1 ] for their comments on our article, a review of the multifunctionality of angiopoietin-like 4 in eye disease...
Biosci Rep (2018) 38 (5): BSR20180557.
Published: 14 September 2018
...Xinyue Yang; Yan Cheng; Guanfang Su Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional cytokine regulating vascular permeability, angiogenesis, and inflammation. Dysregulations in these responses contribute to the pathogenesis of ischemic retinopathies such as diabetic retinopathy (DR), age...
Biosci Rep (2018) 38 (5): BSR20171459.
Published: 07 September 2018
...Sushant Kumar Das; Yi Feng Yuan; Mao Quan Li To explore whether or not inhibition of protein kinase C βII (PKC βII) stimulates angiogenesis as well as prevents excessive NETosis in diabetics thus accelerating wound healing. Streptozotocin (STZ, 60 mg/kg/day for 5 days, i.p.) was injected to induce...
Biosci Rep (2018) 38 (4): BSR20180563.
Published: 31 July 2018
... Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . angiogenesis endothelial cells induced pluripotent stem cells wound healing Due to poor circulation and prolonged tissue ischaemia, many patients...
Includes: Supplementary data
Biosci Rep (2018) 38 (4): BSR20180346.
Published: 03 July 2018
... higher expression level in the ischemic muscle from diabetic mice when compared with nondiabetic mice. Knockdown of miR-133a using antagomir improved perfusion recovery and angiogenesis in experimental PAD model with diabetes day 21 after HLI. On the other hand, overexpression of miR-133a impaired...
Biosci Rep (2018) 38 (1): BSR20171455.
Published: 13 February 2018
... been considered to be important for angiogenesis and arteriogenesis after tissue ischemia. This review summarizes the latest clinical and experimental developments of the role of ILs in blood perfusion recovery after PAD. The authors declare that there are no competing interests associated with...
Biosci Rep (2018) 38 (1): BSR20171017.
Published: 19 January 2018
... Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Angiogenesis Ewing Sarcoma miR-638 VEGFA Ewing sarcoma (EWS) is a kind of primitive...
Biosci Rep (2017) 37 (6): BSR20171015.
Published: 15 December 2017
... vasodilatation. Angiogenesis also induces increased portal inflow and portosystemic collaterals. The collaterals may induce lethal complications such as gastroesophageal variceal hemorrhage, but the therapeutic effect of vasoconstrictors is still suboptimal due to poor collateral vasoresponsivenss. Curcumin has...
Biosci Rep (2017) 37 (6): BSR20171104.
Published: 05 December 2017
..., angiogenesis as well as neuroimmunological reactions and post-ischemic brain recovery in IS. We also outline therapeutic roles of HMGB1 in IS. Correspondence: Seidu A. Richard ( gbepoo@gmail.com ) 31 07 2017 29 09 2017 18 10 2017 20 10 2017 Cerebral blood vessel occlusion in...
Biosci Rep (2017) 37 (5): BSR20171062.
Published: 27 October 2017
...Ankit Tiwari; Niharika Pattnaik; Archita Mohanty Jaiswal; Manjusha Dixit Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) is a candidate gene for FSHD. FRG1 regulates various muscle-related functions, but studies have proposed its role in development and angiogenesis also, where...
Includes: Supplementary data
Biosci Rep (2017) 37 (5): BSR20170860.
Published: 19 September 2017
... diseases including atherosclerotic vascular disease in coronary, cerebral, and peripheral vessels. Its detrimental effect on vascular system implies the potential application as an inhibitor of angiogenesis. However, the detailed mechanism is unveiled. Inhibitory effect of Hcy was assessed on vascular...
Biosci Rep (2017) 37 (2): BSR20170173.
Published: 10 April 2017
... defective FGF1 mutant (Arg-50 to glutamic acid, R50E) is defective in signalling and antagonistic to FGF1 signalling. R50E suppressed angiogenesis and tumour growth, suggesting that R50E has potential as a therapeutic. However, FGF1 is unstable, and we had to express R50E in cancer cells for xenograft study...
Biosci Rep (2014) 34 (6): e00147.
Published: 04 November 2014
...Laura Rocchi; Stefano Caraffi; Roberto Perris; Domenica Mangieri STS (soft tissue sarcomas) are rare malignant tumours deriving from cells of mesenchymal origin and represent only 1% of all malignant neoplasms. It has been extensively demonstrated that angiogenesis has an important role in cancer...
Biosci Rep (2013) 33 (2): e00019.
Published: 01 February 2013
... epithelium-derived factor), a potent inhibitor of tumour angiogenesis, in a model of intracranial gliomas. To assess its potential of tracking gliomas, MSCs (mesenchymal stem cells) were injected into the cerebral hemisphere and it showed that MSCs infiltrated into the vessel beds and scattered throughout...