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Keywords: apoptosis
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Articles
Biosci Rep (2023) 43 (1): BSR-2019-3845_COR.
Published: 19 January 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis CaSR/PLC/PKC signaling pathway diabetes mellitus endothelial...
Articles
Biosci Rep (2023) 43 (1): BSR-2015-0002_EOC.
Published: 19 January 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis cell cycle epidermal growth factor receptor–nuclear factor-kappa...
Articles
Biosci Rep (2022) 42 (12): BSR-2018-2433_RET.
Published: 22 December 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis circular RNA VANGL1 non-small cell lung cancer This article...
Articles
Biosci Rep (2022) 42 (12): BSR20222171.
Published: 22 December 2022
...João Pessoa Cytochrome c (cyt c ) is an electron transporter of the mitochondrial respiratory chain. Upon permeabilization of the mitochondrial outer membrane, cyt c is released into the cytoplasm, where it triggers the intrinsic pathway of apoptosis. Cytoplasmic cyt c can further reach...
Articles
Biosci Rep (2022) 42 (9): BSR-2019-1062_RET.
Published: 21 September 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Apoptosis Breast cancer Cosmc Metastasis Proliferation Tn and T glycans...
Articles
Biosci Rep (2022) 42 (8): BSR-2019-1348_RET.
Published: 31 August 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis CRR9 laryngeal squamous cell carcinoma miR-182 proliferation...
Articles
Biosci Rep (2022) 42 (8): BSR-2019-0696_RET.
Published: 31 August 2022
...Dongmei Fang; Hongxin Wang; Min Li; Wenwen Wei © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . α-bisabolol apoptosis...
Articles
Biosci Rep (2022) 42 (6): BSR20220341.
Published: 27 June 2022
... hand, JB induced MKN45 cells apoptosis through the mitochondrial pathway, and ultimately effectively inhibited the growth of gastric cancer cells. These results suggest that JB appears to be a promising candidate drug with antigastric cancer activity and warrants further research. Correspondence...
Includes: Supplementary data
Articles
Biosci Rep (2022) 42 (6): BSR20220119.
Published: 17 June 2022
... 06 06 2022 07 06 2022 © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis caspase dimerization fluorescence...
Includes: Supplementary data
Articles
Biosci Rep (2022) 42 (3): BSR20210640.
Published: 16 March 2022
... healing. However, little is known about the mechanism underlying high glucose (HG)-induced decrease in tendon fibroblasts viability. In the present study, the rat models of DFU were established, and collagen deposition, autophagy activation and cell apoptosis in tendon tissues were assessed using...
Articles
Biosci Rep (2022) 42 (3): BSR20212171.
Published: 16 March 2022
... -nitroanilide (GPNA) and silenced the expression of ASCT2 with specific shRNAs. We found that the growth of PC cells was significantly inhibited. Additionally, knockdown of ASCT2 induced apoptosis through the Akt/mTOR signaling pathway. Furthermore, the loss of ASCT2 in BxPC-3 cell xenografts significantly...
Includes: Supplementary data
Articles
Biosci Rep (2022) 42 (2): BSR20190878.
Published: 09 February 2022
... assays. Cell migration and invasion were investigated with a transwell assay. Cell apoptosis was probed with flow cytometry. The expression of apoptosis-associated proteins was examined with Western blots. Result: Combination treatment decreased breast cancer cell viability, colony formation, cell...
Includes: Supplementary data
Articles
Biosci Rep (2022) 42 (1): BSR20211005.
Published: 14 January 2022
..., which accelerates senescence and apoptosis of BMSCs, ultimately leading to poor efficacy. Therefore, improving mitochondrial function and enhancing the antioxidative stress capacity of BMSCs may be an effective way of improving the survival rate and curative effect of BMSCs. In the present study, we...
Includes: Supplementary data
Articles
Biosci Rep (2022) 42 (1): BSR20211464.
Published: 06 January 2022
... Cos-7 cells as kidney cell model. Cos-7 cells were exposed to DOX for a period of 24 h over a range of concentrations, and the LC 50 was determined to be 7 µM. Further investigations showed that cell death was mainly via apoptosis involving Ca 2+ and caspase 9, in addition to autophagy. Regucalcin...
Articles
Biosci Rep (2021) 41 (12): BSR20211577.
Published: 17 December 2021
... 10 2021 22 11 2021 07 12 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis Cancer cell survival...
Articles
Biosci Rep (2021) 41 (10): BSR-2019-1357_RET.
Published: 29 October 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Apoptosis Luciferase reporter assay Matrix metalloproteinases...
Articles
Biosci Rep (2021) 41 (10): BSR-2019-0503_COR.
Published: 29 October 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis bladder cancer cell cycle ENO1 This Correction follows...
Articles
Biosci Rep (2021) 41 (9): BSR20202232.
Published: 03 September 2021
... in the progression of various diseases, including DCM. The purpose of the present study was to explore the role of lncRNA GAS5 in high glucose (HG)-induced cardiomyocyte injury and apoptosis. Materials and methods: We constructed HG-induced AC16 cardiomyocytes and a streptozotocin (STZ)-induced rat diabetes model...
Articles
Biosci Rep (2021) 41 (8): BSR20210952.
Published: 06 August 2021
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . 5-FU apoptosis osteosarcoma PTEN synergistic inhibition WT161 The synthesis of proteins is not a smooth road, but each protein undergoes a series of pitfalls to become fully functional. Protein...
Articles
Biosci Rep (2021) 41 (8): BSR-2020-1627_COR.
Published: 02 August 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis Taxol-resistance The authors of the original article “LncRNA...
Articles
Biosci Rep (2021) 41 (7): BSR20204177.
Published: 28 July 2021
... migration, invasion and promoted apoptosis of AGS cells. More importantly, microRNA-506-5p (miR-506-5p) was predicted as a direct target of SNHG15 by binding its 3′-UTR and further verified using luciferase reporter assay. Meanwhile, the results of rescue experiments revealed that knockdown of miR-506-5p...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (7): BSR20211143.
Published: 12 July 2021
... of J. communis extract (JCo extract) on HCC in vitro and in vivo . In the present study, we found that JCo extract inhibited the growth of human HCC cells by inducing cell cycle arrest at the G 0 /G 1 phase, extensive apoptosis and suppressing metastatic protein expressions in HCC cells. Moreover...
Articles
Biosci Rep (2021) 41 (6): BSR20210477.
Published: 21 June 2021
... investigated the molecular mechanisms underlying the suppressive effect of TMJ-12 specifically on BPH-1 cells. A cytotoxicity assay indicated that TMJ-12 inhibited BPH-1 cell proliferation, while flow cytometry assays showed that TMJ-12 induced G 2 /M phase cell cycle arrest and the apoptosis of BPH-1 cells...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (4): BSR20203905.
Published: 30 April 2021
... of cancers. The aim of the present study is to explore the roles of WT161 in osteosarcoma and its underlying mechanisms. Methods: The anti-proliferative effect of WT161 on osteosarcoma cells was examined using MTT assay and colony formation assay. Cell apoptosis was analyzed using flow cytometer...
Articles
Biosci Rep (2021) 41 (4): BSR-20180861_COR.
Published: 27 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis brain cadmium Fragaria ananassa oxidative stress...
Articles
Biosci Rep (2021) 41 (4): BSR-20170710_RET.
Published: 23 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Apoptosis Gadd45a MicroRNA-374 P53 signaling pathway Proliferation...
Articles
Biosci Rep (2021) 41 (4): BSR20203091.
Published: 22 April 2021
... significantly reduced total blastocyst cell numbers ( P <0.001) and increased apoptosis of blastocyst cells ( P <0.001). Moreover, HU exposure reduced the rate of development of two-celled, four- to eight-celled, blastocyst, and hatching stages after parthenogenetic activation ( P <0.05). Our findings...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (4): BSR-20181859_RET.
Published: 19 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis breast cancer GAS5 miR-221/222 This article is being...
Articles
Biosci Rep (2021) 41 (4): BSR-20192639_RET.
Published: 19 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . acute lung injury apoptosis inflammation PPARγ PTEN/β-catenin pathway...
Articles
Biosci Rep (2021) 41 (4): BSR-20160519_EOC.
Published: 19 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis cell cycle STIM1 Tca-8113 cells tongue squamous carcinoma...
Articles
Biosci Rep (2021) 41 (4): BSR-20180391_EOC.
Published: 19 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . A549 cells Apoptosis Gene silencing Hyperplasia suppressor gene Lung...
Articles
Biosci Rep (2021) 41 (4): BSR20204264.
Published: 09 April 2021
...Mengxin Luo; Xiaoxia Shi; Qi Guo; Shuangyue Li; Qing Zhang; Xiuyan Sun; Fengyuan Piao Increasing evidence suggests that n -hexane induces nerve injury via neuronal apoptosis induced by its active metabolite 2,5-hexanedione (HD). However, the underlying mechanism remains unknown. Studies have...
Articles
Biosci Rep (2021) 41 (4): BSR-20190094_EOC.
Published: 06 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis autophagy mifepristone progesterone receptor antagonist...
Articles
Biosci Rep (2021) 41 (4): BSR-20193419_EOC.
Published: 31 March 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis inflammation miR-143-3p mycoplasmal pneumonia TLR4/MyD88/NF-κB...
Articles
Biosci Rep (2021) 41 (4): BSR20203690.
Published: 31 March 2021
... calcium-dependent cellular pathways including neuronal function, muscle contraction, signal transduction, cell differentiation, proliferation, and apoptosis. Research suggests that C1 and C2 perform similar functions due to their structurally highly similar isoforms. Increasing evidence suggests that C1...
Articles
Biosci Rep (2021) 41 (3): BSR-20180861_EOC.
Published: 26 March 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis brain cadmium Fragaria ananassa oxidative stress...
Articles
Biosci Rep (2021) 41 (3): BSR20201603.
Published: 02 March 2021
... in the view of cell proliferation and apoptosis. Methods: In order to evaluate the effects of LINC00488 on the cellular process of thyroid cancer, we performed a series of in vitro experiments, including cell counting kit-8 (CCK-8) assay, EdU (5-ethynyl-2′-deoxyuridine) assay, flow cytometry, transwell...
Articles
Biosci Rep (2021) 41 (2): BSR-20190503_EOC.
Published: 16 February 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . β-catenin apoptosis bladder cancer cell cycle ENO1 The Editorial...
Articles
Biosci Rep (2021) 41 (1): BSR20203219.
Published: 29 January 2021
... in A549 cells in response to H 2 O 2 stimulation. Additionally, peptidyl-prolyl isomerase activity was required for PI3K/Akt activation by CypA. The present study showed that CypA protected A549 cells from H 2 O 2 -induced oxidative injury and apoptosis by activating the PI3K/Akt/mTOR pathway. Thus, CypA...
Articles
Biosci Rep (2021) 41 (1): BSR20203874.
Published: 29 January 2021
... was used to deplete the expression of LMNB2 in human TNBC cell lines including MDA-MB-468 and MDA-MB-231. Alterations in cell proliferation and apoptosis in vitro and the nude mouse tumorigenicity assay in vivo were subsequently analyzed. The human TNBC tissues shown high expression of LMNB2 according...
Articles
Biosci Rep (2021) 41 (1): BSR20203495.
Published: 29 January 2021
...Liqi Yao; Paul Swartz; Paul T. Hamilton; A. Clay Clark Caspase (or cysteinyl-aspartate specific proteases) enzymes play important roles in apoptosis and inflammation, and the non-identical but overlapping specificity profiles (that is, cleavage recognition sequence) direct cells to different fates...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (1): BSR20203834.
Published: 22 January 2021
... bromide) assay, 4′,6-diamidino-2-phenylindole (DAPI) stain, annexin V/ propidium iodide (PI) stain, and protein analysis of apoptosis and mitogen-activated protein kinase (MAPK) pathways). Further, the anticancer effect in vivo was confirmed through a xenograft model. Our results showed that shikonin...
Articles
Biosci Rep (2021) 41 (1): BSR20201541.
Published: 12 January 2021
... apoptosis by flow cytometric analysis and TUNEL assay. Furthermore, the capability of migration and invasion was obviously enhanced on C1QTNF6 overexpression. Conclusion: Overall, our results demonstrated that inhibition of C1QTNF6 attenuated cell proliferation, migration, invasion and promoted apoptosis...
Articles
Biosci Rep (2021) 41 (1): BSR20200884.
Published: 07 January 2021
...) in LUAD remains to be fully inquired. Therefore, our study was conducted to elucidate the DUXAP8 expression in LUAD and its mechanism on the biological features of LUAD cells. Loss-of-function experiments were performed to assess the function of DUXAP8 proliferation and apoptosis of H1975 and A549 cells...
Articles
Biosci Rep (2021) 41 (1): BSR20202717.
Published: 05 January 2021
... the protective effect of GanDouLing (GDL) on neural stem cell (NSC) function in a mouse model of WD. NSCs were treated with different concentrations of GDL alone or in combination with penicillamine, following which we evaluated cellular growth, apoptosis, and differentiation. Nuclear factor E2-related factor 2...
Articles
Biosci Rep (2020) 40 (12): BSR20200936.
Published: 14 December 2020
..., and apoptosis of prostate cancer cells by MTT, CCK8, Edu stain, TUNEL stain, and flow cytometry. Binding proteins of CircGOLPH3 were identified by RNA pull-down, mass spectrometry, and RNA-binding protein immunoprecipitation (RIP) assays. The expressions of CircGOLPH3 and CBX7 were measured by qRT-PCR...
Articles
Biosci Rep (2020) BSR20201735.
Published: 03 December 2020
.... Rheumatoid arthritis methotrexate miR-22 inflammatory reactions apoptosis WITHDRAWN ARTICLE WITHDRAWN: Lipid nanoparticles co-loaded with miRNA-22 and methotrexate for enhanced anti-inflammatory response in rheumatoid arthritis Hao Yuan; Ya-Meng Peng; Zhen-Yi Long; Si-Xian Wu; Yi-Feng Zhou Biosci Rep...
Articles
Biosci Rep (2020) 40 (11): BSR20201573.
Published: 02 November 2020
...Ni Li; Linwen Zhu; Hua Zhou; Dawei Zheng; Guodong Xu; Lebo Sun; Jianqing Gao; Guofeng Shao To determine whether up-regulation of miR-1183 targeting the gene for anti-apoptotic factor, B-cell lymphoma 2 (BCL-2) contributes to apoptosis in patients with rheumatic heart disease (RHD). Peripheral blood...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (11): BSR20201854.
Published: 02 November 2020
... Interactive Analysis (GEPIA). The viability, proliferation, migration, invasion and apoptosis of breast cancer cells were respectively measured by MTT assay, clone formation assay, scratch wound-healing assay, Transwell assay and flow cytometry. PRR11 and epithelial-to-mesenchymal transition (EMT)-related...
Articles
Biosci Rep (2020) 40 (10): BSR20201901.
Published: 14 October 2020
... reporter assay. After transfection, cell viability, apoptosis, migration, and invasion were detected by MTT, flow cytometry, wound healing, and transwell assays, respectively. The expressions of PTEN, Bax, Bcl-2, cleaved Caspase-3, p-PI3K, PI3K, p-AKT, and AKT were detected by Western blot. Results: MiR-25...