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Keywords: autophagy
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Articles
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (1): 1–30.
Published: 22 January 2025
... muscle remodeling and provide avenues for future research to improve our understanding of autophagy in human skeletal muscle. Correspondence: Nathan Hodson ( [email protected] ) 18 10 2024 03 12 2024 11 12 2024 © 2025 The Author(s). 2025 This is an open access article...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (11): BSR-2019-0094_RET.
Published: 15 November 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis autophagy mifepristone progesterone receptor antagonist...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2019-0163_RET.
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . annulus fibrosus cell autophagy mechanical tension senescence...
Articles
Journal:
Bioscience Reports
Biosci Rep (2024) 44 (8): BSR-2018-0544_RET.
Published: 22 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy intervertebral disc degeneration nucleus pulposus resveratrol...
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (9): BSR20221789.
Published: 23 September 2022
..., we summarize diverse evidence that support the role of peptides in this endeavor. Of particular interest to the present review are antimicrobial peptides (AMP) and cell-penetrating peptides (CPP). Different experimental evidence indicates that AMP/CPP are able to regulate autophagy, which in turn...
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (6): BSR-2017-1691_RET.
Published: 30 May 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy curcumin Osteoarthritis This Retraction follows...
Articles
Yanhui Hao, Wenchao Li, Hui Wang, Jing Zhang, Haoyu Wang, Ji Dong, Binwei Yao, Xinping Xu, Li Zhao, Ruiyun Peng
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (4): BSR20212584.
Published: 19 April 2022
... autophagy in neurons. However, the mechanisms underlying microwave-induced autophagy were still unclear. In the present study, we established neuronal damage models by exposing rat hippocampal neurons and rat adrenal pheochromocytoma (PC12) cell-derived neuron-like cells to 30 mW/cm 2 microwaves, which...
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (3): BSR20210640.
Published: 16 March 2022
... healing. However, little is known about the mechanism underlying high glucose (HG)-induced decrease in tendon fibroblasts viability. In the present study, the rat models of DFU were established, and collagen deposition, autophagy activation and cell apoptosis in tendon tissues were assessed using...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (10): BSR20211056.
Published: 06 October 2021
.../M phase in H1299 cells. Mitochondria-mediated apoptosis was induced in A549 cells but not in H1299 cells after treatment with digoxin. Moreover, digoxin inhibited the migration, invasion, adhesion and epithelial–mesenchymal transition of A549 and H1299 cells. Autophagy was induced in both cell lines...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (8): BSR20211098.
Published: 20 August 2021
...Samuel Chuah; Valerie Chew Uveal Melanoma (UM) is a rare cancer deriving from melanocytes within the uvea. It has a high rate of metastasis, especially to the liver, and a poor prognosis thereafter. Autophagy, an intracellular programmed digestive process, has been associated with the development...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (6): BSR-2017-0803_RET.
Published: 14 June 2021
... epithelial cells Autophagy Chronic obstructive pulmonary disease Endoplasmic reticulum stress This Retraction follows an Expression of Concern relating to this article previously published by Portland Press. This article is being retracted from Bioscience Reports at the request of the Editor...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (5): BSR-20171691_EOC.
Published: 14 May 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy curcumin Osteoarthritis The Editorial Office has been made...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (5): BSR-20160523_RET.
Published: 14 May 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy CRISPR/Caspase-9 glioma methylation TET1 This Retraction...
Articles
Yong Huang, Yaqian Huang, Yehua Zhou, Jie Cheng, Chanjun Wan, Maohong Wang, Chiheng Pi, Guoqing Wu, Weiguo Song
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (5): BSR20203362.
Published: 04 May 2021
..., our data demonstrated that Shensu IV can prevent glomerular podocyte injury in nephrotic rats and puromycin-treated podocytes, likely via promoting lncRNA H19/DIRAS3-regulated autophagy. The mass spectrometry (MS) analysis was carried out using an Agilent 6545 Q-TOF. Electrospray ionization (ESI...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20191041_EOC.
Published: 07 April 2021
... autophagy mTORC ovarian cancer PD-L1 The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. © 2021 The Author(s). 2021...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20190094_EOC.
Published: 06 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis autophagy mifepristone progesterone receptor antagonist...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (3): BSR20203812.
Published: 19 March 2021
...Zhuotao Zheng; Lingyue Zhang; Zewei Tu; Yan Deng; Xiaolong Yin Autophagy is involved in cancer initiation and progression but its role in uveal melanoma (UM) was rarely investigated. Herein, we built an autophagy-related gene (ARG) risk model of UM patients by univariate Cox regression and least...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20200842.
Published: 27 January 2021
... the prosurvival autophagy so as to improve the antitumor efficiency of chemotherapeutic drugs on GC cells. Meanwhile, transcript level of DDIT3, which is an apoptosis-related tumor suppressor gene downstream of mTORC1, was regulated by omeprazole-induced FTO silence through an m 6 A-dependent mechanism...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20203231.
Published: 15 January 2021
...Wenfang Xu; Wenke Guo; Ping Lu; Duan Ma; Lei Liu; Fudong Yu The poor prognosis of hepatocellular carcinoma (HCC) calls for the development of accurate prognostic models. The growing number of studies indicating a correlation between autophagy activity and HCC indicates there is a commitment...
Articles
Maomao Gao, Fengjiao Hu, Manli Hu, Yufeng Hu, Hongjie Shi, Guo-Jun Zhao, Chongshu Jian, Yan-Xiao Ji, Xiao-Jing Zhang, Zhi-Gang She, Hongliang Li, Lihua Zhu
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (11): BSR20200661.
Published: 19 November 2020
... that Sop significantly mitigated TAC-induced heart dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis. Mechanistically, Sop treatment induced a remarkable activation of AMPK/mTORC1-autophagy cascade following sustained hypertrophic stimulation. Importantly, the protective effect of Sop was largely...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (9): BSR20201918.
Published: 28 September 2020
... could inhibit proliferation, induce G 2 /M cell cycle arrest and apoptosis, and could inhibit autophagy of acute leukemia cell lines in vitro . Thus, our findings suggest that SOV could effectively suppress the growth of acute leukemia HL60 cells and HL60/A cells through the regulations of proliferation...
Articles
Xiaole Chen, Kaimei Nie, Xin Zhang, Shuangyu Tan, Qingmei Zheng, Yaduan Wang, Xiaofeng Chen, Zhiyu Tang, Rui Liu, Mengru Yan, Zhiwei Liu, Jianbo Lin, Jianhua Xu, Nanwen Zhang, He Wang, Juhua Yang
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (9): BSR20194515.
Published: 18 September 2020
... the activation of caspase-9 and PARP, which are the apoptotic signaling pathway proteins activated by hTNF-α. Meanwhile, lysosome autophagy signaling pathways stimulated by hTNF-α were inhibited by FVH1-1, which down-regulated the expression of LC3II/LC3I and up-regulated the expression of P62, indicating...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (7): BSR-20170803_EOC.
Published: 27 July 2020
... Alveolar epithelial cells Apoptosis Autophagy Chronic obstructive pulmonary disease Endoplasmic reticulum stress The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (7): BSR-20160523_EOC.
Published: 02 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy CRISPR/Caspase-9 glioma methylation TET1 The Editorial...
Articles
In Collection
Coronavirus
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (4): BSR20200905.
Published: 28 April 2020
...Anthony O. Fedele; Christopher G. Proud Autophagy is dependent upon lysosomes, which fuse with the autophagosome to complete the autophagic process and whose acidic interior permits the activity of their intraluminal degradative enzymes. Chloroquine (CQ) and bafilomycin A1 (BafA) each cause...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (4): BSR20193006.
Published: 31 March 2020
...Xiaomin Liu; Xiaowen Zhao; Rong Cheng; Yusen Huang Purpose: Autophagic dysfunction and abnormal oxidative stress are associated with cataract. The purpose of the present study was to investigate the changes of cellular autophagy and oxidative stress and their association in lens epithelial cells...
Includes: Supplementary data
Articles
Shichang Yan, Huimin Ding, Junyang Peng, Xinqiang Wang, Chenglong Pang, Juncheng Wei, Jianjun Wei, Hui Chen
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (3): BSR20192620.
Published: 25 March 2020
... autophagy via regulation of MAPK/NF-κB signaling pathway in vivo and in vitro , and PAR2 can be considered as a potential candidate to treat OA. At present, autophagy has been found to be involved in many biological processes, including cell survival, aging and death. Autophagy plays a very wide role...
Articles
Mathias Lundberg, Sophie Curbo, Hannes Bohman, Ingrid Agartz, Sven-Ove Ögren, Cesare Patrone, Shiva Mansouri
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (1): BSR20193156.
Published: 24 January 2020
... 2019 09 01 2020 © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy clozapine fluoxetine haloperidol ketamine...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (12): BSR20191041.
Published: 20 December 2019
... of mTORC. In addition, PD-L1 promotes the autophagy of ovarian cancer cells by up-regulating the expression of BECN1, a crucial molecule involved in the regulation of autophagy. In conclusion, PD-L1 may provide a target for the development of a novel strategy for the treatment of ovarian cancer. © 2019...
Articles
Jingjing Liu, Hongsheng Liang, Chen Chen, Xiaoxing Wang, Faling Qu, Haiyang Wang, Kongbin Yang, Qing Wang, Ning Zhao, Jing Meng, Aili Gao
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (12): BSR20192489.
Published: 06 December 2019
... agent due to its inhibitory effects on the proliferation of glioma cells in vitro and in vivo . However, the ability of IVM to induce autophagy and its role in glioma cell death remains unclear. The main objective of the present study was to explore autophagy induced by IVM in glioma U251 and C6 cells...
Articles
Zhao-Peng Wang, Difei Shen, Yan Che, Ya-Ge Jin, Sha-Sha Wang, Qing-Qing Wu, Heng Zhou, Yan-Yan Meng, Yuan Yuan
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (12): BSR20191860.
Published: 04 December 2019
... II and p-AMPK expression. It was also found that CRA blunted cardiomyocyte hypertrophy and promoted autophagy in Angiotensin II (Ang II)-treated H9c2 cells. Moreover, to further verify whether CRA inhibits cardiac hypertrophy by the activation of autophagy, blockade of autophagy was achieved by CQ...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (10): BSR20190679.
Published: 21 October 2019
... but decrease the expression of ZEB2. BTXA could significantly inhibit the proliferation, cell cycle, and migration and promote apoptosis and autophagy of HSFBs; however, miR-1587 and miR-2392 inhibitors could reverse these effects of BTXA on HSFBs. Silencing ZEB2 could significantly attenuate the effects...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (9): BSR20191452.
Published: 06 September 2019
.... In the present study, we aimed to elucidate the anti-autophagy and anti-apoptosis effects of ginkgetin via nuclear factor κB (NF-κB)/p53 pathway in cerebral I/R rats. Methods : Rats were administrated 2-h occlusion of right middle cerebral artery before the 24-h reperfusion followed. There were three doses...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (8): BSR20170770.
Published: 23 August 2019
...Jie Liu; Zhiyuan Chen; Jia Guo; Lei Wang; Xiuheng Liu Prostate cancer (PCa), the second most mortal cancer from developed countries, presents a high level of chemoresistance. There is emerging evidence underscores the critical role of autophagy in the onset, progression, and chemoresistance of PCa...
Articles
Tension induces intervertebral disc degeneration via endoplasmic reticulum stress-mediated autophagy
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (8): BSR20190578.
Published: 07 August 2019
... the cells were treated with 9 mM 4-PBA and/or CHOP-siRNA4, the apoptosis rate, ROS level, lysosome activity and expression of PARP, Caspase-12, Caspase-3, LC3, Beclin-1 and CHOP were significantly reduced. Conclusions: Autophagy reaction mediated by endoplasmic reticulum stress plays important rale...
Articles
Xiaonan Zhang, Shaoyang Dong, Qiujin Jia, Ao Zhang, Yanyang Li, Yaping Zhu, Shichao Lv, Junping Zhang
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (8): BSR20190788.
Published: 02 August 2019
... in a variety of CVDs through post-transcriptional regulation of target gene proteins. Among them, microRNA-30 (miR-30) is one of the most abundant miRNAs in the heart. In recent years, the study found that the miR-30 family can participate in VR through a variety of mechanisms, including autophagy, apoptosis...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (7): BSR20182274.
Published: 30 July 2019
... hepatocellular carcinoma A3 (EPHA3) on endometriosis, with emphasis on the autophagy and apoptosis of macrophages via inhibition of the mammalian target of rapamycin (mTOR) signaling pathway. Methods: The mouse models of endometriosis were established followed by culturing the macrophages and macrophage...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (7): BSR20190035.
Published: 23 July 2019
... that SMG damage and repair often occur with autophagy in the rat. However, no studies reported whether secretory inhibition and structural changes of SMG after BTXA injection is related with autophagy. The present study was carried out to explore the association between BTXA injection and autophagy in rat...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (7): BSR20190094.
Published: 23 July 2019
... (PRA) requires more attention. Hence, the current study aimed to examine whether mifepristone, a PRA, influences the autophagy and apoptosis of uterine leiomyoma cells. Primary uterine leiomyoma cells were collected from 36 patients diagnosed with uterine leiomyoma to establish PR-M-positive (PR-M...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (6): BSR20181367.
Published: 25 June 2019
... on the impairments of cells proliferation and mobility potential due to OGD/R administration were assessed in the current study. At the molecular level, the current study detected the expressions of indicators involved in autophagy and PI3K/Akt/mTOR-mediated apoptosis pathways. The OGD/R administration induced...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (6): BSR20190459.
Published: 20 June 2019
... carcinoma (LSCC). We aimed to investigate the effects of PHN on the proliferation and apoptosis of HEp-2 cells. In the present study, PHN alone showed little effect on HEp-2 cell proliferation and apoptosis. Subsequent tests showed that PHN could largely enhance the level of autophagy on HEp-2 cells...
Articles
Fukai Wang, Xiang Song, Shuangshuang Ma, Chenyu Liu, Xiaohui SUN, Xinzhao Wang, Zhaoyun Liu, Dong Liang, Zhiyong Yu
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (6): BSR20190502.
Published: 07 June 2019
... concentrations of EECR. Cell proliferation was examined using Cell Counting Kit-8 (CCK-8) and colony formation assays. Cell apoptosis and cell cycle were detected by flow cytometry. Apoptosis- and autophagy-related protein expression was detected by Western blot. EECR inhibits the proliferation of TNBC cells...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (4): BSR20180650.
Published: 26 April 2019
... staining, and cardiac functions were calculated according to echocardiographic evaluation. Cell viability in cardiomyocytes was investigated by Cell Counting Kit-8 (CCK-8) and lactate dehydrogenase (LDH) release assays. Western blot was used to detect autophagy-related proteins including Beclin-1, LC3, p62...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (4): BSR20190163.
Published: 17 April 2019
... to investigate AF cell senescence under mechanical tension and the potential role of autophagy. Methods: Rat AF cells were cultured and experienced different magnitudes (5% elongation and 20% elongation) of mechanical tension for 12 days. Control AF cells were kept static. Cell proliferation, telomerase activity...
Articles
Giorgia Foggetti, Laura Ottaggio, Debora Russo, Carlotta Mazzitelli, Paola Monti, Paolo Degan, Mariangela Miele, Gilberto Fronza, Paola Menichini
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (2): BSR20181345.
Published: 19 February 2019
... for their ability to induce the degradation of mutp53 through the activation of autophagy. Here, we investigated the correlation between autophagy and mutp53 degradation induced by suberoylanilide hydroxamic acid (SAHA), an FDA-approved histone deacetylase inhibitor. In the human cancer lines MDA-MB-231 (mutp53...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (1): BSR20181707.
Published: 15 January 2019
... of chamaejasmine is newly discovered from Stellera chamaejasmine L. Our study focuses on investigating the effect of chamaejasmine on the cellular apoptosis, proliferation, autophagy, and the underlying mechanisms in MG-63. Methods: Our study investigated the concentration of chamaejasmine in MG-63 cells by MTT...
Articles
Ruben Adrian Grosso, Paula Virginia Subirada Caldarone, María Cecilia Sánchez, Gustavo Alberto Chiabrando, María Isabel Colombo, Claudio Marcelo Fader
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (1): BSR20181156.
Published: 03 January 2019
...Ruben Adrian Grosso; Paula Virginia Subirada Caldarone; María Cecilia Sánchez; Gustavo Alberto Chiabrando; María Isabel Colombo; Claudio Marcelo Fader Hemin is an erythropoietic inductor capable of inducing autophagy in erythroid-like cell lines. Low-density lipoprotein receptor-related protein 1...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20181822.
Published: 30 November 2018
...Xiaokun Lin; Lei Han; Jialei Weng; Kelai Wang; Tongke Chen Objective To investigate the effect of Rapamycin on proliferation and autophagy in human neuroblastoma (NB) cell lines and to elucidate the possible mechanism. Methods NB cells were treated with different concentrations of Rapamycin. Cell...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20180876.
Published: 21 November 2018
..., of which, the sediments were mitochondrial fractions. The isolated mitochondrial or cytosolic fraction was collected for Western blot and mitochondrial membrane potential (ΔΨm) assay. Acute renal injury Apoptosis Autophagy Contrast media mitochondrial injury Oxidative stress Contrast...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (5): BSR20180516.
Published: 23 October 2018
...Qingqing Yin; Wei Feng; Xianjuan Shen; Shaoqing Ju Autophagy is an important process in endogenous substrate degradation by lysosomes within cells, with a degree of evolutionary conservation. Like apoptosis and cell senescence, cell autophagy is a very important biological phenomenon involving...
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