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Keywords: bioinformatics
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Articles
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (5): BSR20230067.
Published: 18 May 2023
... . In addition, quantitative proteomics and bioinformatics analysis confirmed that PPT1 acts by affecting the metabolism, localization, and function of various macromolecular proteins. The present study reveals that PPT1 could be a promising therapeutic target for the treatment of HCC. These findings provided...
Includes: Supplementary data
Articles
Rodolfo Gamaliel Avila-Bonilla, Jorge Antonio Velazquez-Guzman, Eimy Itzel Reyes-Zepeda, Jorge Luis Gutierrez-Avila, César A Reyes-López, Alondra Cisneros-Sarabia, Emma Saavedra, Angel Lopéz-Sandoval, Esther Ramírez-Moreno, César López-Camarillo, Laurence A. Marchat
Journal:
Bioscience Reports
Biosci Rep (2023) 43 (2): BSR20221911.
Published: 09 February 2023
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Correspondence: Laurence A. Marchat ( [email protected] ) bioinformatics mRNA processing protein-protein interactions protozoa therapeutic markers Gene expression regulation allows...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (8): BSR20212835.
Published: 31 August 2022
... investigated by bioinformatic analyses. Results: A ferroptosis-related gene signature ( ALOX5, TFRC, PHKG2, FADS2, NOX1 ) was constructed using multivariate Cox regression analysis and represented as a risk score. Overall survival (OS) probability was significantly lower in the high-risk group than in the low...
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (7): BSR20220251.
Published: 15 July 2022
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . acetylation/deacetylation acetyltransferases bioinformatics immunomodulation inflammation toll-like receptors Since several scientific publications suggest that LPCAT2 participates...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (1): BSR20211939.
Published: 28 January 2022
... Cancer Cell Line Encyclopedia (CCLE) database is a tumor genomics research project led by the Broad Institute Research Institute, which collects the taxonomic data from more than 1000 tumor cell lines. We used both databases to verify the expression level of CCNB2 at different levels. bioinformatics...
Articles
Jian Guan, Jinru Weng, Qiaosheng Ren, Chunbin Zhang, Liantao Hu, Wenjun Deng, Shizhen Lu, Xinyu Dong, Weidong Li, Yue Li, Weiqun Wang
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (12): BSR20212403.
Published: 22 December 2021
..., the mechanisms of CXCL3 in head and neck squamous cell carcinoma (HNSCC) remain unclear. In our study, multiple databases were used to explore the expression level, prognostic value, and related mechanisms of CXCL3 in human HNSCC through bioinformatic methods. We also performed further experiments in vivo...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (12): BSR-2021-0198_RET.
Published: 17 December 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bioinformatics Human bone marrow mesenchymal stem cells Human umbilical...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (12): BSR20212026.
Published: 08 December 2021
... and survival in various types of cancers was analyzed by the PrognoScan database ( http://www.abren.net/PrognoScan/ ) [ 22 ]. The threshold was adjusted to a Cox P -value < 0.05. Bioinformatics OV Platinum resistance Prognosis ZNF76 The mRNA expression profiles and clinical features...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (12): BSR20212218.
Published: 07 December 2021
.... bioinformatics biomarkers breast cancer master regulators surfaceome transcriptomics While advances in therapeutic options and diagnostic tools have significantly improved breast cancer (BRCA) survival, BRCA incidence has continuously increased over the years, especially in high-income countries [ 1...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (10): BSR20211429.
Published: 12 October 2021
... of Hunan University of Chinese Medicine (Ethical approval number: HUCM-15021) and were in accordance with the National Institute of Health’s Guide for the Care and Use of Laboratory Animals. Atherosclerosis Bioinformatics Chinese Medicine Danggui Buxue Decoction Herb Medicine Integrated...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (10): BSR20211615.
Published: 12 October 2021
... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Correspondence: Chunhui Li ( [email protected] ) or Chuan Fang ( [email protected] ) * These authors contributed equally to this work. bioinformatics Brain metastasis tumor...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (7): BSR20210158.
Published: 28 July 2021
... 2021 15 07 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics Head and neck cancer Immune Prognosis...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (7): BSR20204301.
Published: 01 July 2021
... Commons Attribution License 4.0 (CC BY) . bioinformatics immune-related genes pancreatic cancer prognostic model Pancreatic cancer (PC) is a highly malignant cancer and the seventh leading cause of mortality worldwide [ 1 ]. It is predicted that PC will become the second leading cause...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (7): BSR20210033.
Published: 01 July 2021
...Nese Unver The patterns of chemokine expression play a decisive role in both breast cancer prognosis and metastasis. In a recent article published in Bioscience Reports , ‘Bioinformatics identification of CCL8/21 as potential prognostic biomarkers in breast cancer microenvironment’, Chen et al...
Articles
Jinzhou Zheng, Wenhao Xu, Wangrui Liu, Haijia Tang, Jingen Lu, Kui Yu, Xiaoyun Song, Feng Li, Yu Wang, Rui Wang, Lili Chen, Hailiang Zhang, Yunhua Qiu, Gaomeng Wei, Xiqiu Zhou, Jianfeng Yang
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (6): BSR20204421.
Published: 10 June 2021
... enrichment analysis data were obtained from the Bioinformatics Annotation Database (DAVID, https://david.ncifcrf.gov ). We compared the expression of genes in ccRCC cells and datasets with normal kidney tissue expression. In addition, we only selected datasets containing more than 20 samples. We...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (5): BSR20210231.
Published: 21 May 2021
... solution was added to each well. The absorbance at the OD450 nm was detected with a microplate reader after incubation for 2 h. The experiment was repeated three times. bioinformatics DLGAP5 glioma LMNB1 prognosis proliferation Glioma is the most common primary cancer in the central...
Articles
Lulu Wang, Yongtao Li, Xiaodong Zhang, Na Liu, Shiyang Shen, Shizhu Sun, Yang Jiang, Penghui Li, Haifeng Jin, Lei Shen
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (5): BSR20210198.
Published: 20 May 2021
.... We used bioinformatics to predict these processes. In vitro , BMSCs were stimulated in a high-glucose (HG) environment with 50 or 100 μg/ml IL-8 was used as the IL-8 group. A total of 5 μmol/l Triciribine was added to the two IL-8 groups as the Akt inhibitor group. Cultured human umbilical vein...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (3): BSR20203235.
Published: 17 March 2021
... in such injury. The molecular and genetic basis of VILI has been investigated comprehensively by a large number of studies, and it has been found that gene activation plays an important role in the pathophysiological process of VILI [ 11 ]. Bioinformatics analysis, a new approach to studying gene function...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20203458.
Published: 12 January 2021
... under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics diagnostic indicator serum miRNAs stroke WGCNA Stroke, also known as cerebral vascular accident, is one of the most prevalent causes of death and long-term disability worldwide [ 1 , 2 ]. A comprehensive...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20202564.
Published: 08 January 2021
...Yali Wang; Kun Zheng; Xiuqiong Chen; Rui Chen; Yanmei Zou Background: The present study aimed to use bioinformatics tools to explore pivotal genes associated with the occurrence of gastric cancer (GC) and assess their prognostic significance, and link with clinicopathological parameters. We also...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20203459.
Published: 07 January 2021
... ( N = 501). Open targets provide a target-centric workflow to aid in identifying diseases potentially related to specific targets [ 28 ]. Here, we used Open targets to explore diseases related to CXCL10. bioinformatics cancer tumor Thyroid cancer is not only the most common...
Articles
Chang-Kyu Oh, Yeji Ko, Jeong Jun Park, Hye Jin Heo, Junho Kang, Eun Jung Kwon, Ji Wan Kang, Yoonsung Lee, Kyungjae Myung, Jin Mo Kang, Dai Sik Ko, Yun Hak Kim
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20203204.
Published: 06 January 2021
... ( [email protected] ) © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . abdominal aortic aneurysm bioinformatics FRZB gene...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (11): BSR20201820.
Published: 17 November 2020
... 2020 28 10 2020 © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics cancer immunology microRNA Head...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (10): BSR20201012.
Published: 28 October 2020
... an immune-related gene (IRG) prognostic model in STAD using bioinformatics analysis. Methods: RNA sequencing data from healthy samples and samples with STAD, IRGs, and transcription factors were analyzed. The hub IRGs were identified using univariate and multivariate Cox regression analyses. Using the hub...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (10): BSR20200980.
Published: 13 October 2020
... ) Bioinformatics CIBERSORT Differentially expressed genes Stomach adenocarcinoma Tumor microenvironment Stomach adenocarcinoma (STAD) is one of the most gastrointestinal malignancies, ranking the fifth in cancer incidence and the third in cancer mortality worldwide. Although the 5-year survival rate...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (9): BSR20201713.
Published: 18 September 2020
...(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics hub gene Rheumatoid arthritis In the present study, we combined bioinformatics...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (9): BSR20193995.
Published: 16 September 2020
... techniques in basic research has been increasingly recognized by scientists, as it allows for the identification of new genes and noncoding RNAs linked to multiple diseases, providing potential clues and scientific evidence for further studies using bioinformatics tools [ 14 ]. In the present study, the gene...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (9): BSR20202346.
Published: 16 September 2020
... the Creative Commons Attribution License 4.0 (CC BY) . Bioinformatics Computational biology Pulmonary Arterial Hypertension Transcriptomics Pulmonary arterial hypertension (PAH) is a common disorder worldwide characterized by irreversible remodeling of the distal pulmonary arteries...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (8): BSR20200894.
Published: 28 August 2020
...Kaifei Zhao; Lin Xu; Feng Li; Jin Ao; Guojun Jiang; Rongshu Shi; Fang Chen; Qing Luo Background: Due to the heterogeneity of hepatocellular carcinoma (HCC), hepatocelluarin-associated differentially expressed genes were analyzed by bioinformatics methods to screen the molecular markers for HCC...
Includes: Supplementary data
Articles
Zhimin Ye, Jun Fang, Zhun Wang, Lei Wang, Bin Li, Tongxin Liu, Yuezhen Wang, Jianfeng Hua, FangZheng Wang, Zhenfu Fu
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (8): BSR20201727.
Published: 20 August 2020
... 07 2020 14 07 2020 © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bioinformatics ceRNA core genes DEGs Esophageal...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (8): BSR20200963.
Published: 20 August 2020
... colorectum tissues, were selected from GSE81558. Correspondence: Li Feng ( [email protected] ) 27 03 2020 13 08 2020 14 08 2020 14 08 2020 bioinformatics biomarker hub genes overall survival primary colorectal cancer Primary colorectal cancer (PCRC...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (8): BSR20201555.
Published: 17 August 2020
.... bioinformatics key gene papillary thyroid carcinoma RNA-Seq Thyroid carcinoma is presently the malignancy with the most rapidly increasing incidence in the world and is the most widely recognized endocrine carcinoma in the Western world [ 1 ]. Thyroid cancers, derived from follicular thyroid cells...
Articles
Weichun Tang, Jie Li, Xinxia Chang, Lizhou Jia, Qi Tang, Ying Wang, Yanli Zheng, Lizhou Sun, Zhenqing Feng
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (8): BSR20201261.
Published: 07 August 2020
... License 4.0 (CC BY) . bioinformatics biological function hub genes Ovarian cancer prognostic model Ovarian cancer (OC) is the most lethal malignant disease in the female reproductive system, with over 200000 new cases and 150000 deaths each year worldwide [ 1 ]. Epithelial OC accounts...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (7): BSR20194429.
Published: 27 July 2020
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bioinformatics Biomarker Bladder cancer CDC20 therapeutics Bladder cancer (BC) is the ninth most common diagnostic cancer and the second most common...
Includes: Supplementary data
Articles
Xinrong Li, Yue Zhu, Maria Keaton, Ancha Baranova, Sha Liu, Xiaodong Hu, Qi Li, Long Cheng, Peng Zhou, Hongbao Cao, Yong Xu
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (7): BSR20201083.
Published: 21 July 2020
... with mental retardation and taking antipsychotic drugs, anti-manic drugs, antidepressants or mood stabilizers. In addition, we excluded patients with serious excitement or impulsive behavior. bioinformatics peroxisome proliferator-activated receptors psychotic disorders Schizophrenia (SCZ...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (6): BSR-20181016_COR.
Published: 19 June 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cervical cancer HMGB1 prognosis bioinformatics The authors...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (5): BSR20193377.
Published: 27 May 2020
... Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics gene glioma Malignant gliomas are the most common primary brain tumors in adults. Usually, low-grade gliomas (WHO I/II) are not diagnosed...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (3): BSR20194255.
Published: 27 March 2020
...). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics expression glioma prognosis WNT Glioma represents the most frequent primary...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (3): BSR20200298.
Published: 20 March 2020
... in the cytokine production, a series Cytokine Antibody Arrays were performed to detect differentially expressed cytokines between control and HIP-55 knockdown cells. A total of 97 differentially expressed cytokines were identified from 300 cytokines in A549 cell. Bioinformatics analysis showed...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (2): BSR20192724.
Published: 25 February 2020
...). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bioinformatics Head and neck cancer Immune cell prognosis TCGA Head and neck cancer (HNC...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (11): BSR20191511.
Published: 13 November 2019
... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics Hub genes Neuropathic pain Peripheral nerve injury Neuropathic pain is one of the most frequent forms of pathological pain, and is normally induced by somatosensory system injury...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (7): BSR20191612.
Published: 29 July 2019
... Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics biomarker head and neck squamous cell carcinoma prognosis PYGM TNNC2 Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20182172.
Published: 31 May 2019
...-like receptor (NLR) signaling pathway. qPCR showed the same expression trend of hub gene ACLY as in our bioinformatics analysis. Conclusion : Bioinformatics analysis revealed that ACLY and the pathways involved are possible target in the molecular mechanism of type 2 diabetes. © 2019 The Author(s...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20181514.
Published: 17 May 2019
... circRNAs between the tumour tissues and paracancerous tissues of three osteosarcoma patients. Bioinformatics analysis was used to analyse their potential functions. Five differentially expressed circRNAs were selected to detect the relative expression level in tumour and paracancerous tissues of ten...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20182109.
Published: 14 May 2019
... the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics colon cancer cell apoptosis cell cycle molecular docking Tetrandrine Tetrandrine (Tet), bisbenzylisoquinoline alkaloids isolated from Stephania tetrandra and other related species of Menispermaceae , is considered...
Articles
Beata Gajda-Deryło, Thomas Stahnke, Stephan Struckmann, Gregor Warsow, Kerstin Birke, Marco T. Birke, Bettina Hohberger, Robert Rejdak, Georg Fuellen, Anselm G. Jünemann
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20181894.
Published: 02 May 2019
... 07 03 2019 01 04 2019 09 04 2019 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics ophthalmology...
Includes: Supplementary data
Articles
Liuhong Zheng, Yuhan Zhang, Yajun Fu, Hangdi Gong, Jianjun Guo, Kangjing Wu, Qiaojun Jia, Xianfeng Ding
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (2): BSR20181284.
Published: 15 February 2019
... of bioinformatics prediction with experimental verifications indicated that lncRNA MALAT1 can regulate BLCAP mRNA expression through binding to miR-339-5p. Correspondence: Xianfeng Ding ( [email protected] ) 28 07 2018 09 01 2019 16 01 2019 25 01 2019 © 2019 The Author(s). 2019...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20181178.
Published: 07 December 2018
...) with poor OS in grade II male HCC patients (Supplementary Table S1). Taken together, these results suggested that mRNA expression levels of GINS subunits may have prognostic prediction values in HCC patients, especially in male subgroup. bioinformatics GINS hepatocellular carcinoma prognosis...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (2): BSR20171208.
Published: 21 March 2018
... in vascular endothelial injury. It is an important factor in the development of diabetes mellitus (DM). The aim of the present study was to screen out the potential candidate microRNAs (miRNAs) in DM patients with BSS by high-throughput sequencing (HTS) and bioinformatics analysis. Human umbilical vein...
Articles
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (5): BSR20170844.
Published: 17 October 2017
... 09 2017 15 09 2017 © 2017 The Author(s). 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics knee osteoarthritis rs187084...
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