... to research TTN gene mutations in THCA and to investigate their prognostic value in THCA. bioinformatics analysis gene mutations poor prognosis thyroid cancer TTN gene The Genomics of Drug Sensitivity in Cancer (GDSC) database ( http://www.cancerRxgene.org ) is the largest public resource...

...Yao Song; Meiling Lu; Lijin Feng; Qian Chen; Hua Huang; Qing Lin Breast cancer is a serious malignancy with a high incidence worldwide and a tendency to relapse. We used integrated bioinformatics analysis to identify potential biomarkers in breast carcinoma in the present study. Microarray data...

... of the present study was to apply bioinformatics analysis to explore tumor-educated platelet (TEP) microRNA (miRNA) expression and its potential diagnostic utility in HCC. Methods: Twenty-five HCC patients and 25 healthy controls were included. RNA sequencing was utilized to screen miRNA alterations in platelets...

... molecules were predicted based on molecular docking. This investigation identified hub genes, signal pathways and therapeutic agents, which might help us, enhance our understanding of the mechanisms of GDM and find some novel therapeutic agents for GDM. bioinformatics analysis differentially expressed...

... established by STRING and Cytoscape software for further study. Finally, miRNAs targeted HSP90AA1 were predicted by miRanda. All in all, based on the data of GSE20479 chip, the molecular mechanism of SFN on hepatocytes was studied by a series of bioinformatics analysis methods, and it indicated that SFN might...

... License 4.0 (CC BY) . bioinformatics analysis gene expression profile microarray Skeletal muscle healing wound age Skeletal muscle tissues, which are widely distributed throughout the body, account for 30–50% of total body mass [ 1 , 2 ]. These tissues have a relatively superficial...

... is not yet clear. Our study aimed to systematically identify the genes and microRNA (miRNA) and explore the potential biomarkers associated with HAR by integrated bioinformatics analysis. The mRNA and miRNA expression profiles were obtained from the Gene Expression Omnibus database. We performed Gene...

... represented significantly up- or down-regulated genes, respectively ( Figure 1 ). The top 50 up- and down-regulated genes were shown in the heat map ( Figure 2 ). Bioinformatics analysis of microarray data is increasingly valued as a promising tool in gene expression profiling in inflammatory diseases...

...). bioinformatics analysis DEGs non-TNBC survival analysis TNBC Breast cancer (BC) is the most common malignant disease worldwide and remains a major health problem among women [ 1 ]. Triple-negative BC (TNBC) is a particular subtype of BC, which is diagnosed by lacking the expression of estrogen...

... 21 08 2020 10 09 2020 15 09 2020 © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics analysis...

... to express the level of each circRNA as a fold change. Circular RNA Second-generation sequencing Bioinformatics analysis NK/T-LAHS Biomarker Hemophagocytic lymphohistiocytosis (HLH), also called hemophagocytic syndrome (HPS), is a potentially life-threatening disease characterized...

... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics analysis prognosis serous ovarian cancer TIMER database analysis tumor metastasis weighted gene coexpression network analysis (WGCNA) As one...

...Xiaoling Ma; Jinhui Liu; Hui Wang; Yi Jiang; Yicong Wan; Yankai Xia; Wenjun Cheng Methylation functions in the pathogenesis of cervical cancer. In the present study, we applied an integrated bioinformatics analysis to identify the aberrantly methylated and differentially expressed genes (DEGS...

... prognostic significance is also uncertain. Therefore, it is imperative to recognize that further study is necessary to determine the oncogenic role of CDC20 in breast tumorigenesis. In the present study, we performed a deep bioinformatics analysis of the clinical parameters and survival data related...

..., including eotaxin-2, eotaxin-3, CCL18, IL-4, IL-5, IL-10, IL-12p70, IL-13, and IL-15. Bioinformatics analysis indicated that these mediators were mainly enriched in leukocyte chemotaxis and proliferation, JAK-STAT cascade, asthma, and Th1 and Th2 cell differentiation. Furthermore, seven mediators were...

...) and disease-free survival (DFS). COL10A1 was positively correlated with metastatic relapse-free survival. GSEA analysis revealed that enrichment of TGF-β signaling pathway. 15-leucine-rich repeat containing membrane protein ( LRRC15 ) is a correlated gene of COL10A1. Conclusion: Bioinformatics analysis...

... BY) . Bioinformatics analysis Differentially expressed genes Differentially expressed microRNAs Necrotizing enterocolitis in newborn Necrotizing enterocolitis (NEC) is a devastating disease amongst preterm infants, which is accompanied by chronic neurodevelopmental morbidity and a high death rate ranging...

... BY) . atherosclerosis bioinformatics analysis icariin long non-coding RNA microarray Atherosclerosis (AS), characterized by progressing atherosclerotic plaques formation and luminal narrowing of arteries, underpins coronary artery disease (CAD) with high mortality worldwide [ 1 ]. Despite great advances...

... 04 2019 30 05 2019 16 06 2019 18 06 2019 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics...

... migration of cervical cancer cells. Bioinformatics analysis showed that adherens junction was significant for both P -value and enrichment scores, which was consistent with the clinical study. The underlying molecular mechanisms might be the interaction among HMGB1, RAC1, and CDC42. HMGB1 expression...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics analysis Diffuse large B cell lymphoma differentially expressed genes protein-protein interaction network survival analysis Diffuse large B-cell lymphoma (DLBCL), the most...

... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . breast cancer bioinformatics analysis CD28 polymorphism Breast cancer (BC) is the most frequently diagnosed cancer among women and it is the leading cause of female cancer-related death [ 1 ]. In 2017...

... non-coding (Lnc)RNAs regulated by Hec1 were gained from bioinformatics analysis. The role of LncRNA BX647187, regulated by Hec1, was finally characterized in PCa cells by siRNA. Our results showed that Hec1 mRNA and protein were significantly overexpressed in Human PCa tissues and several PCa cell...