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Keywords: biomarker
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Biosci Rep (2022) 42 (11): BSR20220892.
Published: 25 November 2022
...Zemin Wang; You Ge; Han Li; Gaoqiang Fei; Shuai Wang; Pingmin Wei Currently, the benefits of immune checkpoint inhibitor (ICI) therapy prediction via emerging biomarkers have been identified, and the association between genomic mutation signatures (GMS) and immunotherapy benefits has been widely...
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Biosci Rep (2022) 42 (10): BSR20221128.
Published: 18 October 2022
... prognostic biomarker for ccRCC and is involved in immune system regulation. Correspondence: Haijun Yu ( [email protected] ) or Chaoyan Wu ( [email protected] ) 26 05 2022 07 09 2022 23 09 2022 23 09 2022 © 2022 The Author(s). 2022 This is an open access article...
Includes: Supplementary data
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Biosci Rep (2022) 42 (1): BSR20212446.
Published: 11 January 2022
...Tao Guo; Ran Wei; Dylan C. Dean; Francis J. Hornicek; Zhenfeng Duan Background: Although weak SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) expression is a known diagnostic and prognostic biomarker in several malignancies, its expression...
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Biosci Rep (2021) 41 (12): BSR20211096.
Published: 17 December 2021
..., SERPINA1, SCIN , and SLC28A2 ) were identified to correlate with Th17 cells and COAD prognosis, suggesting one new therapy strategy and some predictive biomarkers of COAD. These findings reported by Li et al. may pave one way to explore the molecular mechanism of COAD further. Correspondence: Hu...
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Biosci Rep (2021) 41 (10): BSR20210908.
Published: 12 October 2021
...Quan Lin; Danli Xie; Liangliang Pan; Yongliang Lou; Mengru Shi Objective: Increasing the efficiency of early diagnosis using noninvasive biomarkers is crucial for enhancing the survival rate of lung cancer patients. We explore the differential expression of non-small cell lung cancer (NSCLC...
Includes: Supplementary data
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Biosci Rep (2021) 41 (8): BSR20203531.
Published: 05 August 2021
...Anze Yu; Kai Guo; Qilin Qin; Changsheng Xing; Xiongbing Zu Background: Evaluation of the feasibility for osteopontin (OPN) to serve as a biomarker in the prognosis and clinical-pathological features of prostate cancer (PCA) patients. Methods: The original publications related to OPN and PCA were...
Includes: Supplementary data
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Biosci Rep (2021) 41 (3): BSR20203812.
Published: 19 March 2021
... of cancer patients and were potential biomarkers for predicting the survival time and therapeutic effect for cancer patients [ 9 , 10 ]. However, studies on the role of autophagy in UM are still rare and relative biomarkers or prognostic signatures were hanging for further excavating and developing...
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Biosci Rep (2021) 41 (3): BSR20204210.
Published: 19 March 2021
..., and their combination as biomarker exhibited a good diagnostic capacity for asthma (AUC = 0.832). These findings offered more insight into the underlying mechanism of how IFN signatures affected asthma. The use of the easy-to-apply IFN-related genes might serve as a promising blood-based biomarker for early diagnosis...
Includes: Supplementary data
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Biosci Rep (2021) 41 (1): BSR20203481.
Published: 27 January 2021
.... The present study aimed to construct regulatory network and seek the potential biomarkers of BC diagnosis and prognosis as well as the molecular therapeutic targets from the perspective of mitochondrial dysfunction. Methods: The microarray data of mitochondria-related encoding genes in BC cell lines were...
Includes: Supplementary data
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Biosci Rep (2021) 41 (1): BSR20203973.
Published: 22 January 2021
...Yexun Song; Wenfang Tang; Hui Li Background: Lung adenocarcinoma (LUAD) is the most frequent histological type of lung cancer, and its incidence has displayed an upward trend in recent years. Nevertheless, little is known regarding effective biomarkers for LUAD. Methods: The robust rank aggregation...
Includes: Supplementary data
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Biosci Rep (2020) 40 (11): BSR20200163.
Published: 13 November 2020
..., it is important to find new biomarkers or therapeutic targets in treatment of NSCLC. Methods : The expression levels of miR-371b-5p were detected by qRT-PCR in NSCLC tissues and cell lines. To evaluate the effect of miR-371b-5p on NSCLC progression, we first transfected the miR-371b-5p inhibitor for construction...
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Biosci Rep (2020) 40 (10): BSR20202812.
Published: 28 October 2020
... TCGA The Cancer Genome Atlas References 1. Yan Y. , Zuo X. and Wei D. ( 2015 ) Concise review: Emerging role of CD44 in cancer stem cells: a promising biomarker and therapeutic target . Stem Cells Transl. Med. 4 , 1033 – 1043 10.5966/sctm.2015-0048 2. Wu...
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Biosci Rep (2020) 40 (9): BSR20192436.
Published: 04 September 2020
... biomarkers. Results: A total of 166 DEGs (101 up-regulated and 65 down-regulated) were identified. The up-regulated DEGs were mainly enriched in regulation of the ERK1 and ERK2 cascade, response to interferon-gamma, cell chemotaxis, and migration in biological processes. In the KEGG pathway analysis, up...
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Biosci Rep (2020) 40 (8): BSR20200963.
Published: 20 August 2020
... 14 08 2020 14 08 2020 © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics biomarker hub genes overall...
Includes: Supplementary data
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Biosci Rep (2020) 40 (6): BSR20200902.
Published: 18 June 2020
...) patients. Circular RNA FUNDC1 (circFUNDC1) has been reported to be the diagnosis and prognosis biomarker of AIS. Therefore, the present study aimed to figure out whether circFUNDC1 could be the potential predictor of SAI that could help to guide preventive treatment. In total, 68 patients were included...
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Biosci Rep (2020) 40 (6): BSR20193808.
Published: 03 June 2020
... signature for prognosis prediction in AML may serve as a prognostic biomarker. Correspondence: Zhaoqun Deng ( [email protected] ) 02 12 2019 13 03 2020 29 04 2020 21 05 2020 © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited...
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Biosci Rep (2020) 40 (4): BSR20194448.
Published: 21 April 2020
... the Creative Commons Attribution License 4.0 (CC BY) . biomarker coronary artery bypass grafting postoperative cognitive dysfunction red cell distribution width Postoperative cognitive dysfunction (POCD) is one of the most common complications after coronary artery bypass grafting (CABG...
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Biosci Rep (2020) 40 (4): BSR20192813.
Published: 15 April 2020
... Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . breast cancer biomarker prognosis overall survival The breast carcinoma is one of the world’s most common cancer in women [ 1 ]. The incidence of breast...
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Biosci Rep (2020) 40 (3): BSR20193484.
Published: 27 March 2020
...-486-3p, demonstrating that circRNA_0058063 regulated FOXP4 expression by competitively binding to miR-486-3p. Taken together, circRNA_0058063 functions by sponging miR-486-3p in BC progression, which could act as a new biomarker and further developed to be a therapeutic target in BC. 07 10 2019...
Articles
Biosci Rep (2020) 40 (2): BSR20181881.
Published: 24 February 2020
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . atrophy biomarker dysplasia H+ K+-ATPase structure-function Warburg effect Metaplasia is the replacement of one...
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Biosci Rep (2020) 40 (2): BSR20194405.
Published: 24 February 2020
... reported to be related not only to the occurrence of liver cancer but also to the causes of some ocular lesions. Purpose A diagnostic standard for the levels of serum biomarkers associated with OM derived from liver cancer in men is urgently needed. Material and methods We examined the association between...
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Biosci Rep (2020) 40 (2): BSR20193678.
Published: 18 February 2020
... 2019 24 01 2020 10 02 2020 11 02 2020 © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Biomarker BIRC5 Breast...
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Biosci Rep (2020) 40 (1): BSR20193349.
Published: 24 January 2020
... prognostic biomarkers for HNSCC patients. Overall, our study lay a groundwork for further investigation into the underlying molecular mechanisms in HNSCC carcinogenesis, providing potential biomarkers and therapeutic targets for HNSCC. Correspondence: Xing Qin ( [email protected] ) 25 09...
Includes: Supplementary data
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Biosci Rep (2020) 40 (1): BSR20191251.
Published: 06 January 2020
... various, important roles in osteosarcoma development. The significant 3-lncRNA set could be a novel prediction biomarker that could aid in treatment and also predict the likelihood of recurrence of osteosarcoma in patients. Correspondence: Qingshan Guo ( [email protected] ) or Peng Li...
Includes: Supplementary data
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Biosci Rep (2019) 39 (11): BSR20182224.
Published: 22 November 2019
... between patients with intracranial aneurysm (IA) and healthy control individuals to evaluate their potential use as biomarkers of IA. Arraystar Human lncRNA Microarray v3.0 was performed to identify differentially expressed lncRNAs and mRNAs in plasma samples (4 ml). lncRNAs with the most pronounced...
Includes: Supplementary data
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Biosci Rep (2019) 39 (11): BSR20190966.
Published: 12 November 2019
..., particularly concentrating on ischemic heart disease, CH, and cardiac fibrosis. We next discuss the predictive value of lncRNAs as diagnostic biomarkers of CVDs. Correspondence: Bimei Jiang ( [email protected] ) 18 04 2019 03 10 2019 10 10 2019 10 10 2019 © 2019 The Author(s...
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Biosci Rep (2019) 39 (8): BSR20190884.
Published: 13 August 2019
... at 450 nm. Each experiment was performed in triplicate. © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomarker colorectal...
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Biosci Rep (2019) 39 (8): BSR20190095.
Published: 05 August 2019
... biomarker for predicting favorable overall survival in cervical cancer patients. biomarker cervical cancer immunohistochemistry TP73 Cervical cancer is the second common gynecological tumor worldwide with an estimated 569847 newly diagnosed cases in 2018 [ 1 ]. Despite the fact that cervical...
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Biosci Rep (2019) 39 (7): BSR20191612.
Published: 29 July 2019
.... Therefore, there is an urgent need to have a better understanding of the molecular mechanisms underlying HNSCC progression and to identify essential genes that could serve as effective biomarkers and potential treatment targets. In the present study, original data of three independent datasets were...
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Biosci Rep (2019) 39 (7): BSR20190476.
Published: 26 July 2019
... level was significantly up-regulated in NSCLC patients compared with healthy control subjects ( P <0.0001), and the postoperative THBS2 level decreased significantly ( P <0.0001). ROC curves analysis demonstrated that THBS2 was a comparable biomarker as Cyfra21-1 to distinguish early stage NSCLC...
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Biosci Rep (2019) 39 (6): BSR20190621.
Published: 25 June 2019
.... © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomarker Breast cancer (BCa) circRNA miRNA sponge The characteristic...
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Biosci Rep (2019) 39 (6): BSR20181644.
Published: 18 June 2019
... aggressive phenotypes of LSCC by regulating cell proliferation, migration, invasion, apoptosis, and cell cycle, indicating FTH1P3 may serve as a promising therapeutic biomarker for the treatment of LSCC. Laryngeal cancer is one of the most aggressive cancers of the head and neck, and more than 95...
Articles
Biosci Rep (2019) 39 (5): BSR20190206.
Published: 31 May 2019
.... However, no useful biomarkers for early detection of renal damage in MM exist. Reports indicate that activin A, a multifunctional cytokine of the TGF-β superfamily, is involved in the development and progression of various kidney diseases. In the present study, we measured urinary activin A levels...
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Biosci Rep (2019) 39 (5): BSR20190602.
Published: 17 May 2019
... Biomedical Technology, Beijing, China) at ABI PRISM 7000 Sequence Detection System (Applied Biosystems, Foster City, CA, U.S.A.) following the manufacturer’s protocols. Gene expression was normalized to GAPDH. biomarker lncRNA nephroblastoma SOX21-AS1 Wilms tumor Nephroblastoma, also...
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Biosci Rep (2019) 39 (5): BSR20190667.
Published: 14 May 2019
...Elif Pala; Tuba Denkçeken MicroRNAs (miRNAs) have been proven to play a crucial role in postmenopausal osteoporosis (PMO), and studies on their diagnostic value have been increasing. In our study, we aim to identify the key miRNAs in the PMO that might be potential biomarkers. A comprehensive...
Articles
Biosci Rep (2019) 39 (5): BSR20190612.
Published: 03 May 2019
..., chemotherapy and radiotherapy, the clinical outcome is less than 30% in osteosarcoma patients with distant metastasis, which is obviously poorer than osteosarcoma patients without distant metastasis [ 4 , 5 ]. Therefore, it is essential to find valuable diagnostic or prognostic biomarkers for identifying high...
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Biosci Rep (2019) 39 (4): BSR20182506.
Published: 30 April 2019
... expression was markedly elevated in cervical cancer tissue specimens and cell lines compared with adjacent normal cervical tissue specimens and human normal cervical cell line, respectively. Then, we found high expression of GHET1 is a useful biomarker to discriminate cervical cancer tissues from non...
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Biosci Rep (2019) 39 (4): BSR20190447.
Published: 30 April 2019
... expression in thirty types of human cancer at TCGA database and found that LOXL1-AS1 expression was associated with clinical outcome in nine kinds of tumor. LOXL1-AS1 overexpression was found to be favorable prognostic biomarker in adrenocortical carcinoma, uterine corpus endometrial carcinoma, and uveal...