... aneuploid condition of Down syndrome (DS), a trisomy of chromosome 21. Low blood pressure (hypotension) is a common condition associated with DS and can have a significant impact on exercise tolerance and quality of life. Little is known about the factors driving this hypotensive phenotype, therefore...

... hypertensive (DSHR) animals were then intraperitoneally administered with either CST wild-type (CST-WT) or 364Ser variant (CST-Ser) peptide. CST-Ser was profoundly less effective than CST-WT in rescuing the elevated systolic blood pressure [from ∼211 mmHg to ∼176 mmHg, p < 0.0001 (CST-Ser) versus ∼116 mmHg...

... been extensively reported that the variants of kidney ion handling genes are associated to blood pressure, and clinical features of hypertension. However, the underlying mechanisms by which these variants alter protein function are rarely summarized. In addition, the variation of one single gene...

...Tao Wang; Yang Li; HaiBo Wu; Hua Chen; Yan Zhang; HuiMin Zhou; Hang Li Blood pressure (BP) is a known prognostic marker for mortality in patients on maintenance hemodialysis (MHD). However, definition of the BP and its optimal values vary essentially among different MHD populations. Our purpose...

... during sympathetic blockade with hexamethonium infusion (2 mg/kg over 2 h) on day 3 post-thoracotomy; (c) there was an inverse relationship between burst area and diastolic blood pressure during baroreflex tests undertaken on each recording day. Only recordings with a signal-to-noise ratio of greater...