...Milda Folkmanaite; Manuela Zaccolo Cyclic adenosine monophosphate (cAMP) is a diffusible intracellular second messenger that plays a key role in the regulation of cardiac function. In response to the release of catecholamines from sympathetic terminals, cAMP modulates heart rate and the strength...

... was significantly suppressed with reduced cell membrane localization in breast cancer cells. Furthermore, functional suppression of POPDC1 promoted breast cancer cell migration and proliferation, which were inhibited by POPDC1 overexpression. Finally, cAMP interacts with POPDC1 and up-regulates its expression...

...Sabine Middelhaufe; Martina Leipelt; Lonny R. Levin; Jochen Buck; Clemens Steegborn The second messengers cAMP and cGMP mediate a multitude of physiological processes. In mammals, these cyclic nucleotides are formed by related Class III nucleotidyl cyclases, and both ACs (adenylate cyclases...

... kDa) and Gα s small (48.7 kDa). This is the first demonstration of the stable physical association of AC with both α s subunits of G proteins in human myometrium. © 2003 Plenum Publishing Corporation 2003 Human myometrium adenylyl cyclase cAMP solubilization Bioscience Reports, Vol. 23...

...V.A. Gault; P. Harriott; P.R. Flatt; F.P.M. O'Harte Synthetic fragment peptides of glucose-dependent insulinotropic polypeptide (GIP) were evaluated for their ability to elevate cellular cAMP production and stimulate insulin secretion. In GIP receptor transfected CHL cells, GIP(4–42) and GIP(17–30...

... increases Ca 2+ current at any V h values. The hypothesis is put forward that, during the entrance of ground squirrels into hibernation, the phosphorylation of one of the sites (not cAMP-dependent) of L-type Ca 2+ channels is blocked. © 1999 Plenum Publishing Corporation 1999 Cardiac cells L-type...

... cAMP due to reduced renal function (creatinine clearance). However, 25(OH)D 3 administration had no such impact. 24,25(OH) 2 D 3 opposed the effect of 1,25(OH) 2 D 3 after 12 weeks by significantly augmenting serum P and diminishing serum levels of total Ca and ionized Ca. Cross sectional group...

...Jan O. Gordeladze Rolipram (4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone) represents a new class of specific low K m cAMP phosphodiesterase (PDE) inhibitors. This compound enhances basal, hormone- and forskolin-elicited cAMP accumulation in prolactin (PRL) producing rat pituitary adenoma (GH...

...L. F. Alguacil; M. P. Lopez-Ruiz; J. C. Prieto; C. Alamo; E. Cuenca Neither acute nor prolonged exposure to morphine altered cAMP content or spontaneous movements of longitudinal muscle-myenteric plexus strips of the guinea-pig ileum. By contrast, exogenous acetylcholine or electrical stimulation...

... did not change the, cyclic AMP content in the thyroid gland or the ovary. 1 9 1987 © 1987 Plenum Publishing Corporation 1987 cAMP bromocriptine D 2 receptor Bioscience Reports, Vol. 7, No. 10, 1987 Role of Cyclic AMP in the Action of Dopaminergic D2 Receptors of Some Endocrine...