..., these enzymes generate subcellular cAMP gradients. As a result, only a subset of the downstream effectors is activated and a specific response is executed. Dysregulation of cAMP compartmentalization has been observed in cardiovascular diseases, highlighting the importance of appropriate control of local cAMP...

... mechanisms underlying the effects of ghrelin on the cardiovascular system have not been fully elucidated, and no specific therapeutic agent has been established. It is important to further explore the pharmacological potential of ghrelin pathway modulation for the treatment of cardiovascular diseases...

... in pathophysiological processes of cancer and neurodegenerative, autoimmune, and cardiovascular diseases (CVDs). In recent years, emerging challenges for intervention studies on ischemic heart diseases have received much attention. LncRNAs have a key function in the alleviation of myocardial infarction (MI) injury...

...) with atherosclerotic, cardiovascular disease. So far, a link between common genetic variations of the SGLT2 encoding gene SLC5A2 and glucose homeostasis as well as cardiovascular disease has not been established. The present study, therefore, aimed to investigate SLC5A2 single nucleotide polymorphisms (SNPs...

...Siobhan M. Craige; Kai Chen; Robert M. Blanton; John F. Keaney, Jr; Shashi Kant Cardiometabolic syndrome (CMS) describes the cluster of metabolic and cardiovascular diseases that are generally characterized by impaired glucose tolerance, intra-abdominal adiposity, dyslipidemia, and hypertension...

... of HDL-C. No significant change in BDS-CEC was observed in any combination. These results indicate that BDS-CEC reflects not only the function of HDL but also its concentration in serum. Cardiovascular disease (CVD) is one of the leading causes of death in developed countries [ 1 ]. In most cases...

... angiotensinogen cardiovascular disease hypertension The renin–angiotensin system is an important regulator of many physiological and pathophysiological functions. Drugs inhibiting angiotensin-converting enzyme (ACE) to decrease angiotensin II (AngII) production or antagonizing AT1 receptor lower blood...

...Fei Luo; Tao Wang; Lini Zeng; Shanshan Zhu; Wenjun Cao; Wei Wu; Hongfu Wu; Tangbin Zou Cardiovascular disease (CVD) is a major killer of the human population around the world. Identifying effective diagnostic biomarkers for CVDs is particularly important in order to guide optimizing treatment...

... of cardiovascular disease development. Cholesterol efflux capacity (CEC) is the key metric for determining the antiatherosclerotic function of HDL. However, the assay methods currently used to calculate CEC are not ideal for clinical use as they require the culture of cells. In the present study, we developed...

... in the circulation. They may be useful as new biomarkers to assess the risk of CVD (cardiovascular disease). 1 To whom correspondence should be addressed (email [email protected] ). 4 9 2012 1 10 2012 9 10 2012 16 10 2012 © 2013 The Author(s). 2013 This is an Open Access...