... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . caspases cytokines Gasdermin inflammasome Membrane pore Pyroptosis is a regulated cell death mechanism mostly found in professionally phagocytic cells such as macrophages, monocytes, and dendritic cells...

... increase in the percentage of cells in the late phase of apoptosis and an increased Ca 2 PO 4 deposition at 15 days. The results of quantitative real-time PCR (qRT-PCR) of BAX and BCL2 , and in-cell Western analysis of caspases indicated that the cell death process was independent of caspase-3, -6, -7...

.... Treatment of cells with staurosporine or the death receptor ligand FasL triggers caspase-mediated cleavage of SMSr at a conserved aspartate located downstream of the enzyme’s SAM domain and upstream of its first membrane span. Taking advantage of reconstitution experiments with SMSr produced in a cell-free...

... and their numerous interactions complicate the analysis of their individual functions. Yeast, eukaryotic but unicellular organism, lack the main regulators of apoptosis (caspases, Bcl-2 family members, …) found in mammals. This absence render them a powerful tool for heterologous expression, functional studies...