[email protected] ) * These authors are both corresponding authors. biomarkers ceRNA circRNAs COPD pathogenesis Chronic obstructive pulmonary disease (COPD) is a heterogeneous respiratory disorder with chronic inflammation and incomplete reversible airflow obstruction, which leads to higher...

... and lncRNA in OA is poorly appreciated. Herein, we investigated the functional contribution of lncRNA markers correlated with the progression of human OA by comprehensive bioinformatics analysis of a panoramic network of competing endogenous RNA (ceRNA) based on ferroptosis-related genes (FRGs). Methods...

...-regulated circRNAs and 14 down-regulated circRNAs, we constructed competing endogenous RNA (ceRNA) networks, from which the has-miR-6794-5p has been identified to enriched in the up-regulated network and correlated with the circNFIX directly. At this point, we presented that the circNFIX and MMP9 may play...

... is known to be dysregulated in a variety of tumours. In addition, the ceRNA network plays a crucial role in the occurrence and development of HCC. However, the mechanism by which the ceRNA network regulates G6PD in HCC remains unclear. We used TCGA-LIHC data to analyse the possibility of using G6PD...

... reporter gene binding between miR-211 and CircTHBS1. ( C ) qRT-PCR analysis of miR-211 expression. ( D ) Correlation analysis of co-expression of miR-211 and CircTHBS1. ** P <0.01. CCND2 ceRNA CircTHBS1 Cystitis glandularis miR-211 Data analysis was performed using SPSS 22.0 software...

... as alternative treatments for breast cancer. Thioguanine (6-TG) exerts antitumor effects in cancer. Increasing evidence has demonstrated that competitive endogenous ribonucleic acids (ceRNAs) are involved in cancer processes. However, the mechanism by which 6-TG regulates lncRNA–miRNA–mRNAs has not been...

... miRNAs, and 36 mRNAs, was then established. The functional enrichment analyses showed that the mRNAs in the ceRNA network mainly participated in ‘regulation of transcription’ and ‘pathways in cancer’. Moreover, the Cox regression analyses demonstrated that three lncRNAs (AC112721.1, TMPRSS11GP...

... 07 2020 14 07 2020 © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bioinformatics ceRNA core genes DEGs Esophageal...

...Xiao-Mei Zhang; Jian Wang; Zhu-Long Liu; Hong Liu; Yu-Feng Cheng; Tao Wang LncRNA LINC00657 has oncogenic or anti-carcinoma roles in different cancers, and yet its detailed molecular mechanism in esophageal cancer (EC) remains unclear. In addition, competitive endogenous RNA (ceRNA) regulatory...

... and chemotherapy, the survival and prognosis of advanced patients is still disappointing. Therefore, seeking potential diagnostic and molecular targets for GBC is of great significance [ 6 ]. ceRNA gallbladder cancer LINC01694 miR-340-5p prognosis Sox4 The cultured cells were lysed with radio...

.... Subsequently, 183 hub regulators were selected based on the analysis of node degree in the ceRNA network. Next, a comprehensive analysis of the subgroups and Wnt, mTOR, and MAPK signaling pathways was conducted to understand enrichment of the subgroups. Survival analysis and a receiver operating characteristic...

..., which is detrimental to the in-depth study of this disease. In the present study, ICM susceptibility biomarkers were identified using a proposed strategy based on RNA-Seq and miRNA-Seq data of ICM and normal samples. Significantly differentially expressed competing endogenous RNA (ceRNA) triplets were...

... ]. 18 03 2019 20 06 2019 09 07 2019 10 07 2019 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ceRNA E2F3...

... in tumorigenesis and progression. Competitive endogenous RNAs (ceRNAs) affect other RNAs transcription through competitively binding to common microRNAs (miRNAs). MALAT1 is a typical lncRNA that is markedly up-regulated in breast cancer. However, current understanding of the involvement of MALAT1 in breast cancer...

... (lncRNAs) are a class of ncRNAs with >200 nts in length that regulate gene expression [ 4 ]. In humans, lncRNAs have emerged in the regulation of progression of several tumor types [ 5 ]. LncRNAs could act as competing endogenous RNAs (ceRNAs) with miRNAs to play a post-transcriptional regulatory role...