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Keywords: cell cycle
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Biosci Rep (2024) 44 (2): BSR-2016-0165_RET.
Published: 28 February 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Akt apoptosis cell cycle Cucurbitacin mTOR signalling osteosarcoma PI3K...
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Biosci Rep (2023) 43 (4): BSR-2015-0258_RET.
Published: 21 April 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . TMEM14A cell cycle metastasis ovarian cancer This Retraction follows...
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Biosci Rep (2023) 43 (2): BSR-2015-0258_EOC.
Published: 09 February 2023
... © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell cycle metastasis ovarian cancer THEM14A The Editorial Office has...
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Biosci Rep (2021) 41 (10): BSR-2019-0503_COR.
Published: 29 October 2021
... apoptosis bladder cancer cell cycle ENO1 This Correction follows an Expression of Concern relating to this article previously published by Portland Press. The authors of the original article “Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating...
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Biosci Rep (2021) 41 (9): BSR-20170799_RET.
Published: 13 September 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell cycle Eca-109 cell Esophageal cancer SiRNA Transcription factor 3...
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Biosci Rep (2021) 41 (7): BSR20211143.
Published: 12 July 2021
... of J. communis extract (JCo extract) on HCC in vitro and in vivo . In the present study, we found that JCo extract inhibited the growth of human HCC cells by inducing cell cycle arrest at the G 0 /G 1 phase, extensive apoptosis and suppressing metastatic protein expressions in HCC cells. Moreover...
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Biosci Rep (2021) 41 (7): BSR20210055.
Published: 28 June 2021
... with the poor prognosis of GC patients, the prognostic model was established in TCGA-STAD cohort, and validated in Gene Expression Omnibus (GEO) cohorts, with effectiveness in both HER2 positive and negative patients. DNA methylation was involved in the impact on prognosis. Cell cycle, immune-associated...
Includes: Supplementary data
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Biosci Rep (2021) 41 (6): BSR20210477.
Published: 21 June 2021
... investigated the molecular mechanisms underlying the suppressive effect of TMJ-12 specifically on BPH-1 cells. A cytotoxicity assay indicated that TMJ-12 inhibited BPH-1 cell proliferation, while flow cytometry assays showed that TMJ-12 induced G 2 /M phase cell cycle arrest and the apoptosis of BPH-1 cells...
Includes: Supplementary data
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Biosci Rep (2021) 41 (5): BSR20211016.
Published: 17 May 2021
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biochemical techniques and resources biomarkers cell cycle genomics molecular basis of health and disease The Biochemical Society is one of the U.K.’s largest single-discipline learned societies...
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Biosci Rep (2021) 41 (2): BSR-20190503_EOC.
Published: 16 February 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . β-catenin apoptosis bladder cancer cell cycle ENO1 The Editorial...
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Biosci Rep (2020) 40 (6): BSR20201199.
Published: 19 June 2020
... effective anti-gastric cancer agents based on ISL, aldol condensation reaction was applied to synthesize the ISL analogues. MTS assay was used to evaluate the inhibitory activities of ISL analogues against SGC-7901, BGC-823 and GES-1 cells in vitro . Cell cycle distribution, apoptosis and reactive oxygen...
Includes: Supplementary data
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Biosci Rep (2019) 39 (9): BSR20190880.
Published: 24 September 2019
... 4.0 (CC BY) . 3-Bromopyruvate cell cycle Daunorubicin Hexokinase-II Leukemia Glycolytic shift of energy metabolism is one of the fundamental changes that occur in cancer cells. Otto Warburg first described that even in the presence of adequate amount of oxygen, cancer cells increased...
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Biosci Rep (2019) 39 (9): BSR20190503.
Published: 09 September 2019
... revealed that ENO1 was critical for the growth and proliferation of BC cells. ENO1 over-expression also promoted the proliferation of SV-HUC-1 cells. At the molecular level, the cell cycle and apoptosis related genes were regulated by ENO1. β-catenin expression was positively regulated by ENO1. Furthermore...
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Biosci Rep (2019) 39 (9): BSR20190654.
Published: 06 September 2019
... and enhanced apoptosis in GC cells. The cell cycle progression was suppressed by miR-497-5p. Mechanistically, miR-497-5p directly targeted and suppressed the expression of pyruvate dehydrogenase kinase 3 (PDK3), which is highly expressed in GC tissues. Over-expression of PDK3 promoted the proliferation of GC...
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Biosci Rep (2019) 39 (5): BSR20182109.
Published: 14 May 2019
... of the cell cycle, apoptosis, targets prediction, molecular docking, and alterations in protein levels were performed to elucidate how Tet functions in colon cancer. We found that Tet robustly induced arrest at the G1 phase in colon cancer cell line HT-29. It induced HT-29 cell apoptosis in a dose-dependent...
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Biosci Rep (2019) 39 (5): BSR20190456.
Published: 14 May 2019
... in U2OS cells after treatment with hydroxyurea. In addition, hydroxyurea increased cell apoptosis and altered the cell cycle. TET proteins catalyze the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC); therefore, 5mC and 5hmC levels were evaluated. Increased 5hmC levels were observed...
Includes: Supplementary data
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Biosci Rep (2019) 39 (4): BSR20190040.
Published: 05 April 2019
... of the patients with leukemia. Lentivirus-mediated knockdown of USP39 repressed the proliferation and colony formation of human leukemia cell lines HL-60 and Jurkat cells. Mechanism study showed that USP39 knockdown induced the arrest of cell cycle and apoptosis of leukemia cells. In addition, our microarray...
Includes: Supplementary data
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Biosci Rep (2019) 39 (2): BSR20182306.
Published: 26 February 2019
... enrichment Identification of common up-regulated genes in GSE46234, GSE71989, and GSE107610 ( A ), function enrichment of common up-regulated genes ( B ), and Venny diagram of genes enriched in cell cycle pathway/biological process ( C ). Using the pancreatic...
Includes: Supplementary data
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Biosci Rep (2019) 39 (1): BSR20182201.
Published: 18 January 2019
... pathogenesis. Recombinant HapE was purified for use in downstream assays. MTT and colony formation assays were conducted to determine the effects of HapE on cell viability and growth, while flow cytometry was used to examine changes in cell proliferation and cell cycle function. ELISA was performed to examine...
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Biosci Rep (2019) 39 (1): BSR20180941.
Published: 03 January 2019
... of SNHG14 inhibited NSCLC cell proliferation through inducing cell cycle arrest and apoptosis, whereas SNHG14 overexpression exerted the opposite effects. Animal experiment further revealed that down-regulated SNHG14 greatly inhibited NSCLC tumor growth in vivo . Further studies demonstrated that SNHG14...
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Biosci Rep (2018) 38 (6): BSR20180598.
Published: 21 December 2018
...-related genes. The expressions of both CD31 and CD34 (markers for endothelial progenitor cells) in the FV endothelial cells as well as the proportion of CD31 + /CD34 + cells in peripheral blood were measured in order to evaluate thrombosis. The effect of miR-495 on cell viability, cell cycle...
Includes: Supplementary data
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Biosci Rep (2018) 38 (6): BSR20181384.
Published: 21 November 2018
... that the level of Rhotekin 2 (RTKN2) was up-regulated in osteosarcoma tissues and cell lines. In addition, silencing of RTKN2 of human osteosarcoma cell lines U2OS, inhibited proliferation, and induced G 1 phase cell cycle arrest via reducing the level of the cyclin-dependent kinase 2 (CDK2). Furthermore, RTKN2...
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Biosci Rep (2018) 38 (4): BSR20180005.
Published: 03 July 2018
... assay, BrdU incorporation, wound healing, and colony formation were used to detect melanoma B16F10 cell growth and proliferation. Flow cytometry was used for cell cycle detection. p21 and p27 expression was detected by Western blotting. B16F10 cell xenograft model was established, and treated with CA...
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Biosci Rep (2017) 37 (6): BSR20170799.
Published: 09 November 2017
...-2, Bax, and caspase-3 were determined using Western blotting. Transfection of siTCF-3 successfully down-regulated TCF-3 gene expression. In addition, siTCF-3, reduced Eca-109 cell viability and proliferation, in a time-dependent manner, and inhibited progression of cell cycle from G 0 /G 1 to S...
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Biosci Rep (2017) 37 (4): BSR20170800.
Published: 04 August 2017
... targetting ANKRD49 was constructed in U251 and U87 malignant glioma cells. We demonstrated that ANKRD49 knockdown reduced the proliferation rate of U251 and U87 cells. Further mechanism analysis indicated that depletion of ANKRD49 led to the cell-cycle arrest and induced apoptosis in U251 and U87 cells...
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Biosci Rep (2017) 37 (3): BSR20160478.
Published: 21 June 2017
... 05 2017 11 05 2017 15 05 2017 © 2017 The Author(s). 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell cycle Cell apoptosis...
Includes: Supplementary data
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Biosci Rep (2016) 36 (6): e00405.
Published: 08 November 2016
...-8 assay. Flow cytometry analysis was employed to measure apoptosis of OS cells. Cell cycle distribution was analysed by propidium iodide staining. Transwell assay was performed to evaluate the effect of CuE on invasion potential of OS cells. The protein levels were measured by western blot...
Includes: Supplementary data
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Biosci Rep (2016) 36 (5): e00377.
Published: 16 September 2016
...Ajeena Ramanujan; Swati Tiwari The ubiquitin (Ub) ligase anaphase promoting complex/cyclosome (APC/C) and the tumour suppressor retinoblastoma protein (pRB) play key roles in cell cycle regulation. APC/C is a critical regulator of mitosis and G 1 -phase of the cell cycle whereas pRB keeps a check...
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Biosci Rep (2016) 36 (1): e00298.
Published: 19 February 2016
... patients. In addition, TMEM14A knockdown in two ovarian cancer cell lines, A2780 and HO-8910, reduced cell proliferation, causes cell cycle arrest and suppressed cell invasion. Moreover, silencing of TMEM14A notably repressed G1/S cell cycle transition and cell invasion via down-regulating the expression...
Includes: Supplementary data
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Biosci Rep (2015) 35 (6): e00273.
Published: 26 November 2015
... samples by quantitative real-time (qRT)-PCR. The effects of Hec1 on PCa cells were studied by RNAi approach. Apoptosis and cell cycle were analysed by flow cytometry. Cells viability was evaluated using cell counting Kit-8. Cyclin B1–Cdc2 (cell division cycle 2) activity was measured by ELISA assay. Long...
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Biosci Rep (2014) 34 (6): e00153.
Published: 21 November 2014
... proliferation and migration compared with WT (wild-type) cells. Both Cav-1 KO and WT cells expressed the smooth muscle differentiation markers SM22 and calponin. Cell-cycle phase distribution analysis revealed a higher proportion of Cav-1 KO than WT cells in the S phase. Cav-1 KO cells were hyper-proliferative...
Includes: Supplementary data