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Keywords: cell proliferation
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Articles
Biosci Rep (2021) 41 (4): BSR-20191221_RET.
Published: 14 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cervical cancer cell invasion cell migration cell proliferation CDK5 miR...
Articles
Biosci Rep (2021) 41 (4): BSR-20182476_EOC.
Published: 06 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell proliferation Invasion Migration Oral squamous cell carcinoma PAR-2...
Articles
Biosci Rep (2021) 41 (3): BSR-20180558_EOC.
Published: 26 March 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ATM-E2F1 signaling pathway Cell apoptosis Cell proliferation Long-non...
Articles
Biosci Rep (2021) 41 (2): BSR-20180538_EOC.
Published: 16 February 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell proliferation gastric cancer Hsa_circ_0000673 Invasion miR-532-5p...
Articles
Biosci Rep (2021) 41 (1): BSR20202505.
Published: 05 January 2021
... enzymes were measured by immunoblotting cell extracts. These drug treatments inhibited the growth and survival of SAOS2 and MG63 cells most effectively when used in combination (termed V-BAP). In contrast, V-BAP treated MSCs remained viable with only moderately reduced cell proliferation. V-BAP treatment...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (12): BSR20200936.
Published: 14 December 2020
... cell proliferation and inhibit apoptosis. apoptosis CBX7 cell proliferation circGOLPH3 prostate cancer Correspondence: Shengjun Luo ( luosheng0618@foxmail.com ) * These authors contributed equally to this work. 30 03 2020 30 09 2020 16 11 2020 27 11 2020...
Articles
Biosci Rep (2020) 40 (10): BSR20200485.
Published: 06 October 2020
... proliferation, migration and invasion, but also induced cell apoptosis. Importantly, FOXO1 was a target gene of miR-223 in ALL cells. Silencing of FOXO1 reversed the effects of miR-223 inhibitor on cell proliferation, migration, invasion and apoptosis in ALL. Conclusions: miR-223 could inhibit cell...
Articles
Biosci Rep (2020) 40 (9): BSR20191571.
Published: 21 September 2020
... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell migration cell proliferation glioma miR-302a-3p PSMA3-AS1 RAB22A As the most common solid tumor, glioma is the most common solid tumor in the central nervous...
Articles
Biosci Rep (2020) 40 (8): BSR-20170743_EOC.
Published: 28 August 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell proliferation Epithelial-mesenchymal transition Melanoma cells...
Articles
Biosci Rep (2020) 40 (7): BSR-20192104_RET.
Published: 09 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell adhesion Cell migration Cell proliferation Chemotaxis Hematopoietic...
Articles
Biosci Rep (2020) 40 (7): BSR-20191221_EOC.
Published: 02 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cervical cancer cell invasion cell migration cell proliferation CDK5 miR...
Articles
Biosci Rep (2020) 40 (7): BSR-20181788_EOC.
Published: 02 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell proliferation diabetic retinopathy FGF16 miR-144-3p The...
Articles
Biosci Rep (2020) 40 (7): BSR-20192104_EOC.
Published: 02 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell adhesion Cell migration Cell proliferation Chemotaxis Hematopoietic...
Articles
Biosci Rep (2020) 40 (6): BSR20193815.
Published: 15 June 2020
... SNPRA1 inhibited the cell proliferation, colony formation and xenografted tumorigenesis of HCC cells. Apoptosis was induced by SNPRA1 down-regulation. Mechanistically, SNPRA1 was stimulated by mTOR activation. In addition, whole-genome microarray analysis identified that 262 genes were up-regulated and...
Articles
Biosci Rep (2020) 40 (6): BSR20193788.
Published: 03 June 2020
...Li-Juan Ma; Jun Wu; En Zhou; Juan Yin; Xu-Ping Xiao MiRNAlet-7a is associated with the tumorigenesis of laryngeal squamous cell carcinoma (LSCC). Our study was designed to infer whether let-7a targets high-mobility AT-hook 2 (HMGA2) and suppresses laryngeal carcinoma cell proliferation, invasion...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (4): BSR20200259.
Published: 15 April 2020
... inflammation and cancer. Our study identified microRNA (miR) 145 (miR-145)/gasdermin D (GSDMD) signaling pathway as critical mediators in the effect of tanshinone II A on HeLa cells. In the present study, we found that treatment of tanshinone II A led to an obvious repression of cell proliferation and an...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (3): BSR20192104.
Published: 20 March 2020
... Creative Commons Attribution License 4.0 (CC BY) . Cell adhesion Cell migration Cell proliferation Chemotaxis Hematopoietic stem cells Microvascular endothelial cells Hematopoietic stem cell (HSC) is a type of adult stem cells, whose self-renewal, maintenance, apoptosis and motional...
Articles
Biosci Rep (2019) 39 (7): BSR20191221.
Published: 26 July 2019
...Elena Kapora; Shujun Feng; Wei Liu; Indira Sakhautdinova; Bo Gao; Wenhua Tan MicroRNAs (miRs) are considered to be tumor suppressors or oncogenes as they regulate cell proliferation, migration, invasion, and differentiation. Recently, microRNA-505 (miR-505) has been reported as being involved in...
Articles
Biosci Rep (2019) 39 (7): BSR20181788.
Published: 26 July 2019
.... In the present study, we focussed on a significantly down-regulated miRNA, miR-144-3p, and investigated its role in high glucose (HG) induced cell proliferation. Our data showed that miR-144-3p mimics significantly inhibited HG induced cell proliferation and reduced the percentage of cells in S phase...
Articles
Biosci Rep (2019) 39 (7): BSR20191210.
Published: 12 July 2019
... detect the effects of LINC00982 on the cell proliferation and migration in PTC cells. Furthermore, western blot assay was used to measure the alteration expression levels of apoptosis relative proteins and the relative protein involved phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. Finally...
Articles
Biosci Rep (2019) 39 (7): BSR20190946.
Published: 10 July 2019
...: DEPDC1 was significantly up-regulated in HCC tissues compared with para-cancerous tissues. Besides, patients with high DEPDC1 expression experienced a significantly shorter overall survival. Functional investigations demonstrated that DEPDC1 overexpression facilitated HCC cell proliferation and...
Articles
Biosci Rep (2019) 39 (7): BSR20182476.
Published: 05 July 2019
... 06 2019 © 2019 The Author(s). 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell proliferation Invasion Migration PAR-2 Oral squamous cell...
Articles
Biosci Rep (2019) 39 (5): BSR20182448.
Published: 07 May 2019
... positively associated with differentiation and tumor node metastasis (TNM) stage. Furthermore, the expression of RPN2 was increased significantly in esophageal cancer cell lines compared with normal cells. The effect of RPN2 down-regulation on cell proliferation, cell migration, and cell invasion was...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (4): BSR20190040.
Published: 05 April 2019
...) . Apoptosis Cell proliferation Cell cycle IRF1 Leukemia USP39 Leukemia is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells. These white blood cells are not fully developed and are called blasts or leukemia cells [ 1 ]. Our...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (4): BSR20182186.
Published: 02 April 2019
... in adjacent tissues and closely correlated with histological grade and lymph node (LN) status. Patients with high SNHG20 showed a shorter overall survival (OS) and SNHG20 was an independent risk factor for the prognosis of serous EOC. Knockdown of SNHG20 remarkably inhibited EOC cell proliferation...
Articles
Biosci Rep (2019) 39 (1): BSR20181290.
Published: 08 January 2019
... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell proliferation Mesenchymal stem cells Osteogenic differentiation Tissue inhibitor of metalloproteinase-1 Wnt/β-catenin signaling Bone...
Articles
Biosci Rep (2018) 38 (6): BSR20180558.
Published: 11 December 2018
... distributed under the Creative Commons Attribution License 4.0 (CC BY) . ATM-E2F1 signaling pathway Cell apoptosis Cell proliferation Long-non coding RNA ANRIL Negative feedback regulation Retinoblastoma Retinoblastoma is an aggressive form of an intraocular cancer usually occurring during...
Articles
Biosci Rep (2018) 38 (5): BSR20181042.
Published: 28 September 2018
... Cell Proliferation Assay Kit (Thermo Fisher, #V13154) according to the manufacturer’s protocol. The apoptosis of HUVEC was analyzed with the Annexin V-FITC Apoptosis Detection Kit (Becton Dickinson, #556547) according to the manufacturer’s protocol. The data were analyzed with FACSCalibur flow...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (5): BSR20180538.
Published: 19 September 2018
...; Cell Signaling). Cell proliferation ability was assessed using the MTT assay and clone formation assay. For MTT assay, the cells were seeded in 96-well plates (800 cells/well). Cell proliferation was detected every 24 h according to the manufacturer’s protocol. Briefly, 20 µl MTT solution...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (4): BSR20171675.
Published: 13 July 2018
... elevated in tumor tissues and negatively correlated with miR-1284 expression. MiR-1284 exerted its function by directly binding to 3′-UTR of HMGB1 and regulates expression of HMGB1. The overexpression of miR-1284 inhibited the cell proliferation and migration, and altered the protein expression of...
Articles
Biosci Rep (2018) 38 (2): BSR20180003.
Published: 13 April 2018
.... The miR-10a-5p mimic treatment showed a decline in cell proliferation while the increased rate of cell apoptosis as compared with control. Moreover, knockdown of TBX5 favored the apoptosis and reduced the cell proliferation as compared with control group. We conclude that down-regulation of miR-10a-5p...
Articles
Biosci Rep (2018) 38 (2): BSR20171150.
Published: 16 March 2018
... the cellular mechanism and clinical value of lncRNA GAS5 in ovarian cancer. Methods: Quantitative real-time PCR was used to detect mRNA level of lncRNA GAS5 in 20 ovarian cancer tissues. The effect of lncRNA GAS5 on cell proliferation was performed using CCK-8 assay. Cell apoptosis was evaluated by...
Articles
Biosci Rep (2017) 37 (6): BSR20171038.
Published: 12 December 2017
... specimens and cell lines. Moreover, the inhibition of miR-6743-5p caused a significant inhibition of cell proliferation and a marked promotion of cell apoptosis in glioma cells, and this phenotype was rescued by GRIM-19 knockdown. Finally, the inhibition of miR-6743-5p expression suppressed the...
Includes: Supplementary data
Articles
Biosci Rep (2017) 37 (6): BSR20171039.
Published: 21 November 2017
... migration cell proliferation POPDC1 07 07 2017 20 09 2017 21 09 2017 27 09 2017 © 2017 The Author(s). 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution...
Articles
Biosci Rep (2017) 37 (5): BSR20171019.
Published: 17 October 2017
... lines. Linc00460 expression was positively correlated with ESCC TNM stage, lymph node metastasis, and predicted poor prognosis. In vitro experiments showed that linc00460 depletion suppressed ESCC cell growth through regulating cell proliferation and cell cycle; in additional, linc00460 depletion...
Includes: Supplementary data
Articles
Biosci Rep (2017) 37 (5): BSR20170743.
Published: 07 September 2017
... inhibitors, siRNA-PMEL, and miR-136 inhibitors + siRNA-PMEL, LiC1 (Wnt signaling pathway activator), and siRNA-PMEL+ LiCl groups. MTT, Scratch test, Transwell assay, and flow cytometry were performed to measure cell proliferation, migration, invasion, and apoptosis. Quantitative real-time PCR (qRT-PCR) and...
Articles
Biosci Rep (2017) 37 (4): BSR20170843.
Published: 14 August 2017
..., potentially through interaction with PML nuclear bodies and/or epigenetic control of gene expression. Our study is the first to demonstrate a critical role for RNF168 in the mechanisms regulating cell proliferation and survival, in addition to its well-established role in DNA repair. The expression...
Includes: Supplementary data
Articles
Biosci Rep (2017) 37 (3): BSR20170682.
Published: 21 June 2017
... expression of lncRNA-HEIH promotes melanoma cell proliferation, migration and invasion. Knockdown of lncRNA-HEIH inhibits melanoma cell proliferation, migration and invasion. Mechanistically, we revealed that lncRNA-HEIH directly binds to miR-200b/a/429 promoter and represses miR-200b/a/429 transcription...
Articles
Biosci Rep (2017) 37 (2): BSR20160470.
Published: 10 April 2017
... tumour microenvironment. In the present study, we firstly isolated CAFs from tumour tissues of the patients with ovarian cancer and demonstrated that the hepatocyte growth factor (HGF) was highly expressed in the supernatants of CAFs. CAF-derived HGF or human recombinant HGF promoted cell proliferation...
Articles
Biosci Rep (2016) 36 (6): e00424.
Published: 09 December 2016
... functional role in breast cancer has not been well characterized. In the present study, SIN1 is associated with the progression and survival of breast cancer patients, as well as human breast cancer cell proliferation and migration. SIN1 mRNA level was significantly up-regulated in human breast cancer...
Articles
Biosci Rep (2015) 35 (5): e00245.
Published: 10 September 2015
... spontaneous differentiation of neural stem cells (NSCs), and this mechanism was influenced by miR-146 , as well as its target (notch 1) and downstream gene. cell proliferation differentiation microRNA neural stem cells miRNAs are a fundamental class of biological molecules that play a...
Articles
Biosci Rep (2013) 33 (5): e00069.
Published: 17 September 2013
... which it took effects. The expression of GNAO1 was detected by IHC (immunohistochemistry) and real-time qPCR (quantitative PCR). Cell proliferation test and cell senescence test were then performed to explore the role of GNAO1 in the occurrence and development of HCC. It was revealed that the level of...
Articles
Biosci Rep (1987) 7 (9): 731–736.
Published: 01 September 1987
... phosphoinositide hydrolysis phospholipase C cell proliferation lectins lymphocytes Bioscience Reports, Vol. 7, No. 9, 1987 Anti-Phospholipase C Antibodies Inhibit the Lectin-Induced Proliferation of Human Lymphocytes I. I. Moraru ~, Mioara Manciulea 2, Anca C~llug~lru 2, Gr. Ghyka 2 and L. M. Popescu 1'3...