...Botheina Ghandour; Claudio Pisano; Nadine Darwiche; Ghassan Dbaibo Ceramide (Cer) is a bioactive cellular lipid with compartmentalized and tightly regulated levels. Distinct metabolic pathways lead to the generation of Cer species with distinguishable roles in oncogenesis. Deregulation of Cer...

...Meng Jiang; Shanya Huang; Wang Duan; Qiaoshu Liu; Minxiang Lei Acid sphingomyelinase (aSMase) plays an important role in endothelial dysfunction. Here, we show that elevated aSMase activity and ceramide content were reduced by desipramine treatment in diabetic animals. The inhibitor of aSMase...

... by Western blotting. Ceramide concentration and acid sphingomyelinase (ASM) activity were assayed by HPLC. The cell apoptosis rate was detected by flow cytometry after staining with annexin V/propidium iodide (PI). Compared with HUVECs cultured in 5 mM glucose, cells cultured in 30 mM glucose exhibited...

...Gergana M. Deevska; Manjula Sunkara; Andrew J. Morris; Mariana N. Nikolova-Karakashian The propensity of LDLs (low-density lipoproteins) for aggregation and/or oxidation has been linked to their sphingolipid content, specifically the levels of SM (sphingomyelin) and ceramide. To investigate...

... will be summarized. © 2005 Springer Science+Business Media, Inc. 2005 Viral entry lipid rafts cholesterol sphingolipids ceramide membrane fusion Sphingolipids: Modulators of HIV-1 Infection and Pathogenesis Satinder S. Rawat,1 Benitra T. Johnson,1 and Anu Puri1,2 HIV-1 infects host cells...

...Manju Basu; Patrick Kelly; Peter O'Donnell; Maria Miguel; Mathew Bradley; Sandro Sonnino; Sipra Banerjee; Subhash Basu Ceramide glycanase (CGase) activities have been detected in different human tumor cells (colon, carcinoma Colo-205; neuroblastoma, IMR-32; breast cancer lines, SKBr3 and MCF7...