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Keywords: compartmentalization
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Articles

Regulation of cardiac function by cAMP nanodomains

Open Access
In Collection
Bionanotechnology and Synthetic Biology: applications in precision medicine and allied fields
Milda Folkmanaite, Manuela Zaccolo
Journal: Bioscience Reports
Biosci Rep (2023) 43 (2): BSR20220953.
https://doi.org/10.1042/BSR20220953
Published: 27 February 2023
..., these enzymes generate subcellular cAMP gradients. As a result, only a subset of the downstream effectors is activated and a specific response is executed. Dysregulation of cAMP compartmentalization has been observed in cardiovascular diseases, highlighting the importance of appropriate control of local cAMP...
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Articles

Inositol pyrophosphate synthesis by diphosphoinositol pentakisphosphate kinase-1 is regulated by phosphatidylinositol(4,5)bisphosphate

Open Access
Vasudha S. Nair, Chunfang Gu, Agnes K. Janoshazi, Henning J. Jessen, Huanchen Wang, Stephen B. Shears
Journal: Bioscience Reports
Biosci Rep (2018) 38 (2): BSR20171549.
https://doi.org/10.1042/BSR20171549
Published: 16 March 2018
.... Finally, we discuss the significance of PtdIns(4,5)P 2 as a novel regulator of PPIP5K1, in relation to compartmentalization of InsP 7 /InsP 8 signaling in vivo . © 2018 The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society...
View articletitled, Inositol pyrophosphate synthesis by diphosphoinositol pentakisphosphate kinase-1 is regulated by phosphatidylinositol(4,5)bisphosphate
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