...Carlos M. Farinha; Isabelle Callebaut Cystic fibrosis, the most common autosomal recessive disorder in Caucasians, is caused by mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene, which encodes a cAMP-activated chloride and bicarbonate channel that regulates ion...

...+Business Media, Inc. 2006 MUC4 Mucins IL-9 Airway epithelium ErbB2 Asthma Cystic fibrosis ORI GIN AL PA PER IL-9 Modulated MUC4 Gene and Glycoprotein Expression in Airway Epithelial Cells Gautam Damera Æ Baoyun Xia Æ Hanumatha R. Ancha Æ Goverdhan P. Sachdev Published online: 19 May 2006...

...M. A. Gray; J. P. Winpenny; B. Verdon; H. McAlroy; B. E. Argent Cystic fibrosis (CF) affects approximately 1 in 2000 people making it one of the commonest fatal, inherited diseases in the Caucasian population. CF is caused by mutations in a cyclic AMP-regulated chloride channel known as CFTR, which...

...F. Bertrand; B. Hermelin; A. Paul; I. Garcia; J. Capeau; G. Cherqui; J. Picard In comparison to skin fibroblasts from normal subjects, those from patients with cystic fibrosis (CF): (1) bound [20- 3 H] phorbol 12,13-dibutyrate (PDBu) with a higher affinity (K d =25.8 vs 12.8 nM respectively...

..., A-kinase) to open apical membrane Cl − channels in CF epithelial cells. Most of the physiological abnormalities of CF including elevated sweat electrolytes and hyperviscous mucus can be explained on this basis. 8 12 1987 © 1988 Plenum Publishing Corporation 1988 cystic fibrosis chloride...

...Margaret A. McPherson; Robert L. Dormer 15 4 1987 © 1987 Plenum Publishing Corporation 1987 cystic fibrosis exocrine autonomic cyclic AMP calcium chloride epithelial Abbreviations PIP 2 , phosphatidylinositol 4,5 bis phosphate; DAG, diacylglycerol; InsP 3...