... blood glucose levels, and exhibits antioxidant properties. In diabetic nephropathy, polydatin has been shown to reduce oxidative stress, inflammation, and podocyte apoptosis, thereby preserving renal function. Furthermore, it enhances mitochondrial function and Sirt1 expression in diabetic neuropathy...

...Yuhua Zhang The pathogenesis of diabetic nephropathy (DN) has not been fully elucidated. MicroRNAs (miRNAs) play an important role in the onset and development of DN renal fibrosis. Thus, the present study aimed to investigate the effect of miR-92d-3p on the progression of DN renal fibrosis. We...

...Lili Zhang; Lin Han; Xinmiao Wang; Yu Wei; Jinghui Zheng; Linhua Zhao; Xiaolin Tong The mechanisms underlying the therapeutic effect of Salvia miltiorrhiza (SM) on diabetic nephropathy (DN) were examined using a systematic network pharmacology approach and molecular docking. The Traditional Chinese...

...Hansen Yang; Zheng Zhang; Rui Peng; Luyu Zhang; Handeng Liu; Xinyi Wang; Yiting Tian; Yan Sun Diabetic nephropathy (DN)—a common complication of diabetes—is the primary cause of end-stage renal disease. Sodium butyrate (NaB) is a short-chain fatty acid (SCFA) that is a metabolic product...

...Jiewei Liu; Dongliang Cai; Ying Wang; Yanhong Zou; Tana Zhao Long non-coding RNAs (lncRNAs) are confirmed to be involved in modulating diabetic nephropathy (DN). The present study is aimed to explore the regulatory mechanism of lncRNA small nucleolar RNA host gene 15 (SNHG15) on pediatric DN. Human...

...Zixin Cai; Yan Yang; Jingjing Zhang Background: Diabetic nephropathy (DN) is an important microvascular complication of diabetes. Physical activity (PA) is part of a healthy lifestyle for diabetic patients; however, the role of PA in DN has not been clarified. Our aim was to conduct a meta-analysis...

...Xue Wu; Youye Huang; Yao Zhang; Chunling He; Yongli Zhao; Lizhuo Wang; Jialin Gao The purpose of this meta-analysis was to evaluate the beneficial and adverse effects of tripterygium glycosides (TGs) combined with angiotensin II receptor blocker (ARB) on diabetic nephropathy (DN). We searched...

...Ming Ming Liu; Rui Dong; Zhen Hua; Nan Ning Lv; Yong Ma; Gui Cheng Huang; Jian Cheng; Hai Yan Xu The effects of Liuwei Dihuang pill (LWDH) on diabetic nephropathy-related osteoporosis (DNOP) are unclear. The present study aimed to evaluate the effects of LWDH on KDM7A and Wnt/β-catenin signaling...

... the Editorial Board to manipulation in Figure 2C, as well as duplicated images in Figures 2B, 4B, 7B and 7D. diabetic nephropathy LncRNA- PVT1 miR-93-5p PTEN PI3K/Akt/mTOR pathway mouse mesangial cells © 2020 The Author(s). 2020 This is an open access article published by Portland Press...

...MingJun Shi; PingPing Tian; ZhongQiang Liu; Fan Zhang; YingYing Zhang; LingLing Qu; XingMei Liu; YuanYuan Wang; XingCheng Zhou; Ying Xiao; Bing Guo Diabetic nephropathy (DN) commonly causes end-stage renal disease (ESRD). Increasing evidence indicates that abnormal miRNA expression is tightly...

... nephropathy LncRNA-PVT1 miR-93-5p mouse mesangial cells PI3K/Akt/mTOR pathway Diabetic nephropathy (DN), characterized by decreased glomerular filtration, proteinuria, and renal fibrosis is a common diabetes-associated disease [ 1 ]. DN affects more than 40% diabetic patients worldwide, and leads...

...Li Wang; Hua Li Objective: Diabetic nephropathy (DN) is one of the most severe and frequent diabetic complications. MicroRNAs (miRNAs) have been reported to play a vital role in DN pathogenesis. The present study aimed to investigate the molecular mechanism of miR-770-5p in DN. Methods: Podocyte...

...Jie Su; Jian Ren; Haiyan Chen; Bo Liu Hyperglycemia-induced renal tubular cell injury is thought to play a critical role in the pathogenesis of diabetic nephropathy (DN). However, the role of miRNAs in renal tubular cell injury remains to be fully elucidated. The aim of the present study...

...Huan Lian; Yi Cheng; Xiaoyan Wu Background: Diabetic nephropathy (DN) is the most common complication of diabetes mellitus (DM). The signal pathway and molecular mechanism of renal fibrosis are not fully understood. In the present study, we aimed to explore the function of malignant fibrous...

...Rui Zhang; Xiao Han; Tao Huang; Xiuge Wang Diabetic nephropathy (DN) is the common complications of diabetes mellitus, but the efficacy of available treatments for the prevention of DN is still unsatisfactory. In the present study, we aimed to explore the effect of Danggui buxue tang (DGT...

...Yan Chen; Yan-Jun Wang; Ying Zhao; Jin-Cheng Wang Diabetic nephropathy (DN) is one of the most devastating complications of diabetes mellitus. Carbohydrate response element binding protein (ChREBP) is a basic helix–loop–helix leucine zipper transcription factor that primarily mediates glucose...

...Ying Feng; Ming-yue Jin; Dong-wei Liu; Li Wei A common complication of both type I and type II diabetes is nephropathy, characterized by accumulation of extracellular matrix in the glomerular mesangium. This indicates a central role of mesangial cells in the pathophysiology of diabetic nephropathy...

...Jiandong Lu; Jinting Peng; Min Xiang; Liangping He; Dongcai Wang; Guoliang Xiong; Shunmin Li Trichosanthes kirilowii lectin (TKL) has been reported to exert hypoglycemic effects in alloxan-induced diabetic mice. However, there is no evidence showing that it helps to prevent diabetic nephropathy (DN...

...Juxiang Liu; Xingguang Liu; Youpeng Li; Jinxing Quan; Suhong Wei; Siqin An; Ruifei Yang; Jing Liu The aim of the present study was to investigate the correlation of neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), and platelet distribution width (PDW) with diabetic nephropathy (DN...

...Umapathy Dhamodharan; Krishnamoorthy Ezhilarasi; Balashanmugam Ponjayanthi; Dornadula Sireesh; Kunka Mohanram Ramkumar; Vijay Viswanathan Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease, characterized by progressive albuminuria and conferring additional risk...

... will examine the growing role of DNA methylation in diabetes and its vascular complications, thus it can provide critical implications for the early prevention of diabetes and its vascular complications. 18 12 2016 07 02 2017 09 02 2017 09 02 2017 Diabetic nephropathy is a serious...

...Dong Li; Zhenyu Lu; Zhongwei Xu; Junya Ji; Zhenfeng Zheng; Shan Lin; Tiekun Yan Mechanical stress which would cause deleterious adhesive effects on podocytes is considered a major contributor to the early progress of diabetic nephropathy (DN). Our previous study has shown that spironolactone could...