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Keywords: diethyldithiocarbamate
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Articles

Matrix metalloproteinase-1 induction by diethyldithiocarbamate is regulated via Akt and ERK/miR222/ETS-1 pathways in hepatic stellate cells

Open Access
Tianhui Liu, Ping Wang, Min Cong, Dong Zhang, Lin Liu, Hongyi Li, Qingling Zhai, Zhuo Li, Jidong Jia, Hong You
Journal: Bioscience Reports
Biosci Rep (2016) 36 (4): e00371.
https://doi.org/10.1042/BSR20160111
Published: 24 August 2016
...Tianhui Liu; Ping Wang; Min Cong; Dong Zhang; Lin Liu; Hongyi Li; Qingling Zhai; Zhuo Li; Jidong Jia; Hong You Matrix metalloproteinase-1 (MMP-1) plays an important role in fibrolysis by degrading excessively deposited collagen I and III. We previously demonstrated that diethyldithiocarbamate (DDC...
View articletitled, Matrix metalloproteinase-1 induction by diethyldithiocarbamate is regulated via Akt and ERK/miR222/ETS-1 pathways in hepatic stellate cells
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Articles

The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2- and Akt-dependent mechanism

Open Access
Tianhui Liu, Ping Wang, Min Cong, Youqing Xu, Jidong Jia, Hong You
Journal: Bioscience Reports
Biosci Rep (2013) 33 (3): e00041.
https://doi.org/10.1042/BSR20130033
Published: 05 June 2013
...Tianhui Liu; Ping Wang; Min Cong; Youqing Xu; Jidong Jia; Hong You DDC (diethyldithiocarbamate) could block collagen synthesis in HSC (hepatic stellate cells) through the inhibition of ROS (reactive oxygen species) derived from hepatocyte CYP2E1 (cytochrome P450 2E1). However, the effect of DDC...
View articletitled, The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2- and Akt-dependent mechanism
Open the PDF for The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2- and Akt-dependent mechanism in another window