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Keywords: drug design
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Articles

Biological and mutational analyses of CXCR4–antagonist interactions and design of new antagonistic analogs

Open Access
Qian Meng, Ruohan Zhu, Yujia Mao, Siyu Zhu, Yi Wu, Lina S.M. Huang, Aaron Ciechanover, Jing An, Yan Xu, Ziwei Huang
Journal: Bioscience Reports
Biosci Rep (2023) 43 (12): BSR20230981.
https://doi.org/10.1042/BSR20230981
Published: 22 December 2023
... of antagonists in recognizing CXCR4 and guide the development of new therapeutic agents. chemokine receptor CXCR4 drug design ligand-receptor interactions molecular modeling peptide antagonists small molecule antagonists the Tsinghua-Peking Center for Life Sciences GM057761 the NIH...
View articletitled, Biological and mutational analyses of CXCR4–antagonist interactions and design of new antagonistic analogs
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Includes: Supplementary data
Articles

Apoptosis and apoptotic body: disease message and therapeutic target potentials

Open Access
Xuebo Xu, Yueyang Lai, Zi-Chun Hua
Journal: Bioscience Reports
Biosci Rep (2019) 39 (1): BSR20180992.
https://doi.org/10.1042/BSR20180992
Published: 18 January 2019
..., therapies and drugs designed based on regulation apoptosis and ApoBD formation hold great promises in curing intractable diseases [ 133 ]. This work was supported by the Chinese National Natural Sciences Foundation [grant numbers 81630092, 81773099, 81570790, 81573338]; the National Key R&D...
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Articles

Ethers and esters derived from apocynin avoid the interaction between p47 phox and p22 phox subunits of NADPH oxidase: evaluation in vitro and in silico

Open Access
Martha Edith Macías-Pérez, Federico Martínez-Ramos, Itzia Irene Padilla-Martínez, José Correa-Basurto, Lowell Kispert, Jessica Elena Mendieta-Wejebe, Martha Cecilia Rosales-Hernández
Journal: Bioscience Reports
Biosci Rep (2013) 33 (4): e00055.
https://doi.org/10.1042/BSR20130029
Published: 02 August 2013
..., provided the original work is properly cited. apocynin derivatives drug design inhibitory activity molecular modelling NADPH oxidase There are several components in organisms that produce the superoxide anion (O 2 •− ), the main one is the enzyme NOX (NADPH oxidase) [ 1 – 4...
View articletitled, Ethers and esters derived from apocynin avoid the interaction between p47 phox and p22 phox subunits of NADPH oxidase: evaluation in vitro and in silico
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