... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . annulus fibrosus apoptosis endoplasmic reticulum high glucose...

... disease. endoplasmic reticulum endosomes intracellular transport Lysosomes neurodegeneration neuronal ceroid lipofuscinosis First discovered by Christian de Duve, lysosomes perform several key cellular functions, and their dysfunction has been implicated in several human pathologies...

... biology. Rat AF cells were cultured in baseline medium and culture medium with 0.2 M glucose. The inhibitor 4-PBA was added along with the high glucose culture medium to study the role of endoplasmic reticulum (ER) stress in this process. Compared with the control cells, high glucose significantly...

.... Here we show the carbohydrate-binding domain is crucial for its stability and ability to bind to several glycogen-associated proteins. CBM20 endoplasmic reticulum glucose glycogen STBD1 ubiquitination STBD1 (starch-binding domain-containing protein 1; also known as Genethonin-1...

... chaperones of the Endoplasmic Reticulum (ER)’Calnexin (CN) and Calreticulin (CR). Using a co-immunoprecipitation approach we observed that newly synthesized ApoB associates with CN and CR. The interaction was transient; within 30–60 min after synthesis bulk of newly formed ApoB dissociated. Using McA Rh7777...

... as the physiological implications of Ca 2+ levels within them, have remained elusive. Ca 2+ pools appear to be contained within the endoplasmic reticulum (ER); however, ER is a heterogeneous and widely distributed organelle, with numerous other functions than Ca 2+ regulation. Studies described here center on trying...