..., thus identifying histone monoaminylation as an emerging epigenetic mark, which is highly enriched in cancer cells and possesses significant regulatory functions of gene transcription. In this review, we will summarize recent advances in TGM2-mediated histone monoaminylation as well as its role...

... non-histone proteins, we analyzed the interacting proteins for the presence of an H3K9-like recognition domain, defining a list of novel candidate targets for histone mimicry. Combined, the present study extends the current paradigm on pathways that link, directly or indirectly, to these epigenetic...

... to defect in the neurulation process of embryogenesis. NTDs are among the most common type of birth defects occurring at a range of 0.5–10 in every 1000 live births worldwide and are thought to have multifactorial etiology, including multigenetic and epigenetic notions. Epigenetic regulations control...

... in cancer is immensely influenced by different properties of CSCs such as epithelial-to-mesenchymal transition (EMT), a profound expression of drug efflux pump genes, detoxification genes, quiescence, and evasion of apoptosis, has been highlighted in this review article. The crucial epigenetic alterations...

... was recognized as statistically significant. The standardized mean difference (SMD) and 95% confidence interval (CI) were used to evaluate the differences in lipid levels. coronary artery disease epigenetics lipid metabolism m.5178C>A Sensitivity analysis was conducted in the present...

... & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CSIC. Akirin epigenetics gene regulatory networks histones interactome Subolesin Total proteins were extracted from WT and akirin2 KO HL60 cells using the AllPrep DNA/RNA/Protein Mini...

.... * Corresponding Author; email: [email protected] 02 07 2021 08 05 2021 29 06 2021 Akirin Subolesin gene regulatory networks interactome histones epigenetics 1 Function of cofactor Akirin2 in the regulation of gene expression 2 in model human Caucasian neutrophil-like HL60...

.... In cancers, HDAC10 plays crucial roles in regulating various cellular processes through its epigenetic functions or targeting some decisive molecular or signaling pathways. It also has potential clinical utility for targeting tumors and non-tumor diseases, such as renal cell carcinoma, prostate cancer...

... to diabetes mellitus. Associated complications such as retinopathy, neuropathy, nephropathy and other cardiovascular complications are a direct result of diabetes. Epigenetic factors include deoxyribonucleic acid (DNA) methylation and histone post-translational modifications. These factors are directly...

...Callum J. O’Kane; Edel M. Hyland Saccharomyces cerevisiae (budding yeast) and Schizosaccharomyces pombe (fission yeast) are two of the most recognised and well-studied model systems for epigenetic regulation and the inheritance of chromatin states. Their silent loci serve as a proxy...

...Shanshan Liu; Weiqin Chang; Yuemei Jin; Chunyang Feng; Shuying Wu; Jiaxing He; Tianmin Xu Cervical cancer is the fourth most common female cancer in the world. It is well known that cervical cancer is closely related to high-risk human papillomavirus (HPV) infection. However, epigenetics has...

... therapy should be strongly supported with molecular approaches. However, their successful application depends on a deep understanding of not only genetic, but also epigenetic background of the disease. That will result in an earlier and more precise diagnosis, successful treatment, as well...

...Chelsea R. McCoy; Nateka L. Jackson; Rachel L. Brewer; Mohamad M. Moughnyeh; Daniel L. Smith, Jr; Sarah M. Clinton Epigenetic mechanisms such as DNA methylation elicit lasting changes in gene expression and likely mediate gene–environment interactions that shape brain development, behavior...

...Qianyun Feng; Sheng Zheng; Jia Zheng Osteoporosis, a common and multifactorial disease, is influenced by genetic factors and environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet. Recently, emerging evidence suggests that epigenetic modifications may...

... disease, including kidney disease. It will detail the known mechanisms of fetal programming, including the role of epigenetic modulation. The evidence for the role of maternal obesity in the developmental programming of CKD is derived mostly from our rodent models which will be described. The clinical...

... to infection, it has also been recognized that the ability to progress from an immature Th2 cytokine predominance to a Th1 profile has relevance in determining whether children will develop allergy, providing an opportunity for epigenetic regulation through environmental pressures. However, this notion remains...

... of ‘metabolic memory’. The underlying mechanisms between these enduring effects and the prior hyperglycaemic state are still not well understood. Preliminary studies demonstrate that hyperglycaemia can regulate gene expression by epigenetic modifications, such as DNA methylation, which can persistently exist...

... pyrosequencing epigenetics DNA methylation often occurs in a CpG dinucleotide context and promoter DNA methylation can regulate the expression level of the gene [ 6 , 7 ]. Aberrant DNA methylation has been extensively studied in cancer, lung cancer and leukaemia [ 8 – 10 ]. It is often related...

... that much stronger apoptotic signal was found in OV-H1 hybrid cells inoculated mouse. The hESCs can inhibit the growth of OVCAR-3 cells in vitro by suppressing p53 and PTEN expression to suppress the growth of tumour that may be achieved by inducing apoptosis of OVCAR-3 cells. The change of epigenetics...

... biogeographic or demographic shifts. Mechanistically, mtDNA haplotypes may influence the activity of the electron transport system (ETS), retrograde signalling to the nuclear genome and affect epigenetic modifications. Thus, differential provisioning by macronutrients may lead to selection through changes...

... Attribution Licence (CC-BY) ( http://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. aldosterone epigenetics H2AK119 H3K27 methyltransferase Polycomb The ENaC (epithelial Na...

...://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. aging cancer circadian cycle deleted in breast cancer-1 (DBC1) epigenetics histone deacetylase (HDAC) metabolism Owing to its multiple...

.... By analysing the function of different promoter constructs and the DNA methylation status of three regulatory regions, we demonstrate that the Oct-4A gene in MCF-7 cells is repressed by epigenetic control rather than transcriptional control. In addition, we speculate that the transcription of Oct-4B in MCF-7...

...Jie Yao; Qing Huang; Xiao-Bing Zhang; Wei-Ling Fu Previous studies have suggested an important role of ERs (oestrogen receptors) in the pathogenesis of leukaemias. However, there is no information so far about the epigenetic characteristics of ERα isoforms and ERβ in leukaemias. In the present...