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Keywords: epigenetics
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Biosci Rep (2024) 44 (8): BSR20240493.
Published: 23 August 2024
..., thus identifying histone monoaminylation as an emerging epigenetic mark, which is highly enriched in cancer cells and possesses significant regulatory functions of gene transcription. In this review, we will summarize recent advances in TGM2-mediated histone monoaminylation as well as its role...
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Biosci Rep (2022) 42 (12): BSR20220998.
Published: 06 December 2022
... to defect in the neurulation process of embryogenesis. NTDs are among the most common type of birth defects occurring at a range of 0.5–10 in every 1000 live births worldwide and are thought to have multifactorial etiology, including multigenetic and epigenetic notions. Epigenetic regulations control...
Includes: Supplementary data
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Biosci Rep (2022) 42 (4): BSR20211812.
Published: 19 April 2022
... in cancer is immensely influenced by different properties of CSCs such as epithelial-to-mesenchymal transition (EMT), a profound expression of drug efflux pump genes, detoxification genes, quiescence, and evasion of apoptosis, has been highlighted in this review article. The crucial epigenetic alterations...
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Biosci Rep (2021) 41 (12): BSR20212246.
Published: 17 December 2021
... 2021 03 12 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . coronary artery disease epigenetics lipid metabolism m...
Includes: Supplementary data
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Biosci Rep (2021) 41 (7): BSR20211120.
Published: 22 July 2021
... epigenetics gene regulatory networks histones interactome Subolesin The Akirin (also known as Subolesin (SUB) in ticks) family constitute a model for the study of host–pathogen molecular interactions and functional biology due to their conserved function throughout the metazoan in the regulation...
Includes: Supplementary data
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Biosci Rep (2021) 41 (6): BSR20210462.
Published: 04 June 2021
.... In cancers, HDAC10 plays crucial roles in regulating various cellular processes through its epigenetic functions or targeting some decisive molecular or signaling pathways. It also has potential clinical utility for targeting tumors and non-tumor diseases, such as renal cell carcinoma, prostate cancer...
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Biosci Rep (2020) 40 (9): BSR20202160.
Published: 10 September 2020
... to diabetes mellitus. Associated complications such as retinopathy, neuropathy, nephropathy and other cardiovascular complications are a direct result of diabetes. Epigenetic factors include deoxyribonucleic acid (DNA) methylation and histone post-translational modifications. These factors are directly...
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Biosci Rep (2019) 39 (5): BSR20182006.
Published: 07 May 2019
...Callum J. O’Kane; Edel M. Hyland Saccharomyces cerevisiae (budding yeast) and Schizosaccharomyces pombe (fission yeast) are two of the most recognised and well-studied model systems for epigenetic regulation and the inheritance of chromatin states. Their silent loci serve as a proxy...
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Biosci Rep (2019) 39 (4): BSR20190527.
Published: 12 April 2019
...Shanshan Liu; Weiqin Chang; Yuemei Jin; Chunyang Feng; Shuying Wu; Jiaxing He; Tianmin Xu Cervical cancer is the fourth most common female cancer in the world. It is well known that cervical cancer is closely related to high-risk human papillomavirus (HPV) infection. However, epigenetics has...
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Biosci Rep (2018) 38 (5): BSR20180731.
Published: 23 October 2018
... therapy should be strongly supported with molecular approaches. However, their successful application depends on a deep understanding of not only genetic, but also epigenetic background of the disease. That will result in an earlier and more precise diagnosis, successful treatment, as well...
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Biosci Rep (2018) 38 (3): BSR20180453.
Published: 21 June 2018
...Qianyun Feng; Sheng Zheng; Jia Zheng Osteoporosis, a common and multifactorial disease, is influenced by genetic factors and environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet. Recently, emerging evidence suggests that epigenetic modifications may...
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Biosci Rep (2018) 38 (2): BSR20180050.
Published: 29 March 2018
... disease, including kidney disease. It will detail the known mechanisms of fetal programming, including the role of epigenetic modulation. The evidence for the role of maternal obesity in the developmental programming of CKD is derived mostly from our rodent models which will be described. The clinical...
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Biosci Rep (2017) 37 (2): BSR20160611.
Published: 15 March 2017
... of ‘metabolic memory’. The underlying mechanisms between these enduring effects and the prior hyperglycaemic state are still not well understood. Preliminary studies demonstrate that hyperglycaemia can regulate gene expression by epigenetic modifications, such as DNA methylation, which can persistently exist...
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Biosci Rep (2017) 37 (1): BSR20160408.
Published: 16 January 2017
... represent novel and promising targets for therapeutic development. 20 9 2016 15 11 2016 5 12 2016 8 12 2016 DNA methylation rheumatic heart disease brain natriuretic peptide pyrosequencing epigenetics Rheumatic heart disease (RHD) is primarily an autoimmune sequela...
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Biosci Rep (2016) 36 (5): e00378.
Published: 16 September 2016
... that much stronger apoptotic signal was found in OV-H1 hybrid cells inoculated mouse. The hESCs can inhibit the growth of OVCAR-3 cells in vitro by suppressing p53 and PTEN expression to suppress the growth of tumour that may be achieved by inducing apoptosis of OVCAR-3 cells. The change of epigenetics...
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Biosci Rep (2015) 35 (6): e00277.
Published: 22 December 2015
... biogeographic or demographic shifts. Mechanistically, mtDNA haplotypes may influence the activity of the electron transport system (ETS), retrograde signalling to the nuclear genome and affect epigenetic modifications. Thus, differential provisioning by macronutrients may lead to selection through changes...
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Biosci Rep (2013) 33 (4): e00058.
Published: 23 August 2013
...://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. aging cancer circadian cycle deleted in breast cancer-1 (DBC1) epigenetics histone deacetylase (HDAC) metabolism Figure 2 Functional...
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Biosci Rep (2009) 29 (4): 211–216.
Published: 01 May 2009
...Jie Yao; Qing Huang; Xiao-Bing Zhang; Wei-Ling Fu Previous studies have suggested an important role of ERs (oestrogen receptors) in the pathogenesis of leukaemias. However, there is no information so far about the epigenetic characteristics of ERα isoforms and ERβ in leukaemias. In the present...