..., and ferroptosis-related genes, we identified six hub genes (acyl-CoA synthetase long-chain family member 1 [ ACSL1 ], BACH1 , CBS , CP , AKR1C1 , and AKR1C3 ). Consensus clustering analysis classified samples into two immune-related subgroups, C1 and C2, with single-sample gene set enrichment analysis...

...Moumita Saha; Sanjib Das; Krishnendu Manna; Krishna Das Saha Ferroptosis is a non-conventional cellular death caused by lipid peroxide induced iron deposition. Intracellular lipid accumulation followed by generation of lipid peroxides is an hallmark of non-alcoholic fatty liver disease (NAFLD...

...Tengyun Yang; Guang Yang; Guoliang Wang; Di Jia; Bohan Xiong; Xiaojun Lu; Yanlin Li Background: Ferroptosis and dysregulation of long non-coding RNA (lncRNA) have been described to be strictly relevant to the pathogenesis of osteoarthritis (OA). However, the connection between ferroptosis...

...Yan Hu; Zewei Tu; Kunjian Lei; Kai Huang; Xingen Zhu Background : Glioma is a malignant intracranial tumor and the most fatal cancer. The role of ferroptosis in the clinical progression of gliomas is unclear. Method : Univariate and least absolute shrinkage and selection operator (Lasso) Cox...

...Ke Han; Jukun Wang; Kun Qian; Teng Zhao; Xingsheng Liu; Yi Zhang We wished to construct a prognostic model based on ferroptosis-related genes and to simultaneously evaluate the performance of the prognostic model and analyze differences between high-risk and low-risk groups at all levels. The gene...

... effect in gastric cancer. However, its mechanisms are still not fully understood. In the present study, we found that Tan IIA induced ferroptosis in BGC-823 and NCI-H87 gastric cancer cells. Tan IIA increased lipid peroxidation and up-regulated Ptgs2 and Chac1 expression, two markers of ferroptosis...

... inhibition. DHA has the advantages of low cytotoxicity to normal cells, selective killing effect and low drug resistance, making it one of the popular anti-tumor research directions. Ferroptosis is a newly discovered form of cell death characterized by iron dependence and lipid reactive oxygen species (ROS...