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Keywords: gene expression
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Articles
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (03): 213.
Published: 31 March 2025
... © 2025 The Author(s). 2025 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . gene expression gold nanoparticles histopathology inflammation...
Articles
Ginger extract promotes pancreatic islets regeneration in streptozotocin-induced diabetic rats
Open Access
Journal:
Bioscience Reports
Biosci Rep (2025) 45 (03): 171–184.
Published: 13 March 2025
... BY) . diabetes β-cell development insulin gene expression ginger extract regeneration Extensive research has uncovered fundamental transcription factors underlying the orchestration of pancreatic endocrinogenesis [ 6 ]. During pancreatic organogenesis, all endocrine lineages, including β-cells...
Articles
Correlation of ER, PR, and HER2 at the protein and mRNA levels in Asian patients with operable breast cancer
Open AccessChih-Jung Chen, Ting-Hao Chen, Jason Lei, Ji-An Liang, Po-Sheng Yang, Chiun-Sheng Huang, Chia-Ming Hsieh, Ling-Ming Tseng, Liang-Chih Liu, Skye Hung-Chen Cheng, Kuan-Hui Shih
Journal:
Bioscience Reports
Biosci Rep (2022) 42 (1): BSR20211706.
Published: 18 January 2022
... 10 01 2022 © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Asian population estrogen gene expression HER2...
Articles
Journal:
Bioscience Reports
Biosci Rep (2021) 41 (7): BSR20211241.
Published: 12 July 2021
... in the immune-phenotype gene expression regulatory network. These results provide novel ideas and evidence for HCC regulatory mechanisms that may improve immunotherapy for this cancer. There were 371 and 212 samples in the training cohort of TCGA-LIHC dataset and verification cohort of the ICGC-LIRI-JP...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (12): BSR20202672.
Published: 16 December 2020
... treatment decreased oxidative stress (LPO, NO), down-regulation gene expression levels ( TNF-α, IL-1β , and BAX ), and this antileishmanial activity of nanoparticles was associated with enhanced antioxidant enzyme activities. In addition, histopathological evaluation proved the antileishmanial activity...
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (9): BSR20201084.
Published: 02 September 2020
... Attribution License 4.0 (CC BY) . gene expression genetic variants GWAS Insomnia risk genes sleep disease With the advance of technique, genome-wide association study (GWAS) is widely applied and considered as an effective method that could simultaneously examine the genetic association...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (7): BSR20200467.
Published: 22 July 2020
... default analysis settings and global scaling as normalization method. The values presented are log 2 RMA signal intensity. The microarray data discussed in this article are publicly available at NCBI Gene Expression Omnibus (GEO) under accession number GSE139383 . To explore the possible...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (6): BSR20193938.
Published: 15 June 2020
... and treatment of REPL. The chip data of REPL (GSE63901) were downloaded from the NCBI Gene Expression Omnibus (GEO) database. Weighted Gene Co-Expression Network Analysis (WGCNA) was used to construct a co-expression module for studying the relationship between gene modules and clinical features. In addition...
Includes: Supplementary data
Articles
CD37 high expression as a potential biomarker and association with poor outcome in acute myeloid leukemia
Open Access
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (5): BSR20200008.
Published: 27 May 2020
... leukemia (AML) patients. Methods: The RNA-seq and clinical data of AML patients were obtained from cBioPortal database. CD37 correlated genes, the expression prolife and survival curve of eight key genes were acquired from Gene Expression Profiling Interactive Analysis (GEPIA) and UALCAN. Pathway...
Articles
Jindong Hao, Chengshun Li, Chao Lin, Yang Hao, Xianfeng Yu, Yidan Xia, Fei Gao, Ziping Jiang, Dongxu Wang
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (5): BSR20192933.
Published: 05 May 2020
... instructions. cDNA was synthesized using the First-Strand cDNA Synthesis kit (Promega, U.S.A.). Quantitative real-time PCR (qRT-PCR) was performed to determine H19 , miR675, and m 6 A-related gene expression using the BioEasy SYBR Green I Real-Time PCR Kit on Bio-Rad iQ5 Multicolor Real-Time PCR Detection...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (4): BSR20193185.
Published: 21 April 2020
... with BMD risk. Consistently, differential gene expression analysis found that the PPP1CB gene showed significantly higher expression in low BMD samples than that in high BMD samples based on two independent expression datasets ( P = 0.0026 and P = 0.043, respectively). Together, we provide a convergent...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2020) 40 (3): BSR20194296.
Published: 27 March 2020
... were induced remarkable blood oxidative stress damage, histopathological alterations, up-regulation of IL-6, Nrf2 gene expression, and DNA fragmentation in the examined immune organs of the broiler chickens as well as a significant reduction in the antibody titer against Newcastle (ND) and avian...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (6): BSR20190188.
Published: 28 June 2019
...Zongqiang Gao; Chen Duan; Fang-fang Yu; Xiong Guo Kashin–beck disease (KBD) is endemic chronic osteoarthrosis and its pathogenesis is still unclear. The present study aimed to explore differential gene expression in articular cartilage between patients with rheumatoid arthritis (RA) and KBD...
Articles
Journal:
Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20190235.
Published: 21 May 2019
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Association phenotype analysis dysfunction module disordered molecules gene expression osteosarcoma typing Transcriptional regulation of genes is key regulation in the occurrence and development of diseases, and TFs...
Includes: Supplementary data
Articles
Effect of Taraxacum officinale extract on PI3K/Akt pathway in DMBA-induced breast cancer in albino rats
Open Access
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20180334.
Published: 21 December 2018
... BY) . Breast cancer DMBA Gene expression Taraxacum officinale Breast cancer is the most common form of malignancy and the leading cause of cancer-associated morbidity and mortality among women all over the world [ 1 ]. It attacks more than 500,000 women every year [ 2 ]. Breast cancer...
Articles
Radhakrishnan Vishnubalaji, Muthurangan Manikandan, Abdullah Aldahmash, Abdullah AlJarbou, Mohamad Habous, Dulaim Alhajeri, Raed Almannie, Musaad Alfayez, Nehad M. Alajez, Saleh Binsaleh
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20181015.
Published: 23 November 2018
...). However, the cellular and molecular phenotype of adipose derived stem cells (ADSCs) stromal vascular fraction (SVF) from ED patients remains largely unknown. Herein we compared the global gene expression profile in the SVF from ED patients and healthy individuals and identified altered signaling pathways...
Includes: Supplementary data
Articles
Gene expression data analysis identifies multiple deregulated pathways in patients with asthma
Open Access
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20180548.
Published: 07 November 2018
... with asthma severity or with the response to corticosteroids are still being unraveled. The present study integrated four asthma-related gene expression datasets from the Gene Expression Omnibus and identified immune-gene signatures associated with asthma development, severity, or response to treatment...
Articles
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (4): BSR20180770.
Published: 31 August 2018
..., EXTL2, and EXTL3. While the expression levels of these enzymes change in tumor cells, little is known how this changes the structure and function of HS. In the present study, we investigated gene expression profiles of the EXT family members, their glycosyltransferase activities and HS structure...
Includes: Supplementary data
Articles
Yan. Deng, Xiang. Gan, Da. Chen, Hulian. Huang, Junsong. Yuan, Jiamin. Qiu, Shenqiang. Hu, Jiwei. Hu, Jiwen. Wang
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (2): BSR20171361.
Published: 27 April 2018
...% collagenase which did not impair cell viability ( Figure 1 ). Thus, we finally used 0.1% collagenase to digest the F1 granulosa layers while 0.3% for the pre-hierarchical and F4–F2 granulosa layers. Cell culture Geese Granulosa cells Growing characteristics Gene expression Granulosa cells...
Includes: Supplementary data
Articles
Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD
Open AccessMilla-Maria Tauriainen, Ville Männistö, Dorota Kaminska, Maija Vaittinen, Vesa Kärjä, Pirjo Käkelä, Sari Venesmaa, Helena Gylling, Jussi Pihlajamäki
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (2): BSR20171274.
Published: 20 April 2018
... Attribution License 4.0 (CC BY) . biliary samples gene expression liver samples nafld plant sterols and stanols sitostanol Absorption of sterols from the small intestine and biliary excretion from the liver and bile are regulated by transporter genes Niemann–Pick C1-Like 1 ( NPC1L1 ), ATP...
Includes: Supplementary data
Articles
Dalia Ali, Sarah Abuelreich, Nora Alkeraishan, Najla Bin Shwish, Rimi Hamam, Moustapha Kassem, Musaad Alfayez, Abdullah Aldahmash, Nehad M. Alajez
Journal:
Bioscience Reports
Biosci Rep (2018) 38 (1): BSR20171252.
Published: 30 January 2018
... pathways associated with adipocyte lineage commitment and maturation are not fully delineated. Thus, we performed global gene expression profiling during adipocyte differentiation of human bone marrow stromal (mesenchymal) stem cells (hMSCs) and identified 2,589 up-regulated and 2,583 down-regulated mRNA...
Includes: Supplementary data
Articles
N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity
Open Access
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (4): BSR20170712.
Published: 24 August 2017
...), GAPDH (NM_002046.3), YWHAZ (NM_003406.2) all synthesized by Metabion (Martinsried, Germany). The primer sequences are summarized in Supplementary Table S2. Relative amounts of gene expression were determined with the Rotor-Gene software version 6.1 using the comparative quantification method. GAPDH...
Includes: Supplementary data
Articles
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (2): BSR20160183.
Published: 28 April 2017
...Zhenhua Hu; Wee-Wei Tee Gene expression requires successful communication between enhancer and promoter regions, whose activities are regulated by a variety of factors and associated with distinct chromatin structures; in addition, functionally related genes and their regulatory repertoire tend...
Articles
Qian Zhang, Xiaofang Sun, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Zhixin Wang, Cuijuan Qi, Tong Wang, Xiaojing Wang
Journal:
Bioscience Reports
Biosci Rep (2017) 37 (2): BSR20160362.
Published: 28 April 2017
... the Creative Commons Attribution License 4.0 (CC BY) . chromium development gene expression lipid metabolism PPAR pathway More and more studies in humans reveal that undernutrition in utero leads to the reduction in birth weight [ 1 ], long-term modification in metabolic status [ 2...
Articles
Journal:
Bioscience Reports
Biosci Rep (2015) 35 (3): e00208.
Published: 11 June 2015
... metabolic gene expression was up-regulated in 3D HepaRG spheroids. These results suggest that hanging drop 3D cultures can improve hepatocellular responses as a functional liver. 3D culture gene expression hanging drop HepG2 cells HepaRG cells Recently, the demand to establish...
Articles
Anti-MDR and antitumoral action of acetylsalicylic acid on leukaemic cells
Available to PurchaseMichele Carrett-Dias, Ana Paula de Souza Votto, Daza de Moraes Vaz Batista Filgueira, Daniela Volcan Almeida, Adriana Lima Vallochi, Marcelo Gonçalves Montes D'Oca, Luis Fernando Marins, Gilma Santos Trindade
Journal:
Bioscience Reports
Biosci Rep (2011) 31 (5): 391–398.
Published: 05 August 2011
... of different concentrations of ASA were compared in K562 (non-MDR) and Lucena (MDR) cells by analysing cell viability, apoptosis and necrosis, intracellular ROS (reactive oxygen species) formation and bcl-2 , p53 and cox-2 gene expression. ASA inhibited the cellular proliferation or induced toxicity in K562...
Includes: Supplementary data
Articles
Probing the effect of MODY mutations near the co-activator-binding pocket of HNF4α
Available to Purchase
Journal:
Bioscience Reports
Biosci Rep (2011) 31 (5): 411–419.
Published: 05 August 2011
... compilation © 2011 Biochemical Society 2011 diabetes gene expression hepatocyte nuclear factor 4α (HNF4α) LXXLL motif maturity onset diabetes of the young (MODY) mutation nuclear receptor (NR) HNF4α (hepatocyte nuclear factor 4α) plays an essential role in the development and function...
Includes: Supplementary data
Articles
Effect of mitoxantrone on proliferation dynamics and cell-cycle progression
Available to Purchase
Journal:
Bioscience Reports
Biosci Rep (2010) 30 (6): 375–381.
Published: 24 September 2010
... cytometric measurements. The analysis demonstrated significant cell-cycle arrest on MTX treatment. Inhibition of lacZ gene expression was also observed on drug treatment, which implicates its interaction with gene expression. 1 To whom correspondence should be addressed (email [email protected]...
Includes: Supplementary data
Articles
Methylation status of oestrogen receptor α-A: a predictor of prognosis in leukaemias
Available to Purchase
Journal:
Bioscience Reports
Biosci Rep (2010) 30 (4): 217–222.
Published: 12 March 2010
... contributed equally to this work. 2 To whom correspondence should be addressed (email [email protected] ). 27 3 2009 11 6 2009 25 6 2009 25 6 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 demethylation reagent gene expression leukaemia...
Articles
Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes
Available to Purchase
Journal:
Bioscience Reports
Biosci Rep (2008) 28 (6): 319–326.
Published: 06 November 2008
... gene expression, how the various MBPs (methyl-binding proteins) contribute to this process remains elusive. To determine whether the two well characterized proteins MeCP2 (methyl-CpG-binding protein 2) and MBD1 (methyl-CpG-binding domain 1) have distinct or redundant functions, we employed RNAi (RNA...
Articles
Promoter Characterization and Expression of the Gene Coding for the Human GM2 Activator Protein
Available to PurchaseTommaso Beccari, Chiara Balducci, M. Cristina Aisa, M. Agnese Della Fazia, Giuseppe Servillo, Aldo Orlacchio
Journal:
Bioscience Reports
Biosci Rep (2001) 21 (1): 55–62.
Published: 01 February 2001
... gene expression in transfected COS cells. This sequence contains GC rich region and several putative promoter elements were present, including Sp1, AP2, cAMP-responsive element, and B-cell-specific activating protein. Analysis of tissue distribution of the GM2 activator protein gene revealed tissue...
Articles
Evidence of Mucin Secretion in Human Lung Adenocarcinoma Cell Lines NCIH650 and NCIH2077 and Effect of Select Secretagogues on Mucin Secretion
Available to Purchase
Journal:
Bioscience Reports
Biosci Rep (1999) 19 (5): 473–483.
Published: 01 October 1999
... conditions and only two of the four tested secretagogues significantly increased mucin secretion. Thus, this in vitro model system may be useful in determining alterations in mucin structure, if any, in lung adenocarcinomas as well as in studying the regulation of mucin gene expression. © 1999 Plenum...
Articles
A unified matrix hypothesis of DNA-directed morphogenesis, protodynamism and growth control
Available to Purchase
Journal:
Bioscience Reports
Biosci Rep (1989) 9 (2): 157–188.
Published: 01 April 1989
..., and in the untranscribed part of the genome. 1 A preliminary version of this assay was published previously (cf. Scherrer, 1985). 15 10 1988 © 1989 Plenum Publishing Corporation 1989 matrix hypothesis morphogenesis protodynamics growth control DNA genome organisation gene expression gene...
Articles
The GC box as a silencer
Available to Purchase
Journal:
Bioscience Reports
Biosci Rep (1987) 7 (12): 955–963.
Published: 01 December 1987
... developing sperm cells. gene expression GC box negative regulation © 1987 Plenum Publishing Corporation 1987 23 11 1987 Bioscience Reports, Vol. 7, No. 12, 1987 The GC Box as a Si lencer I Jacek M. Jankowski 2 and Gordon H. Dixon Received November 23, 1987 KEY WORDS: gene xpression; GC...
Articles
α- and β -adrenergic control of thermogenin mRNA expression in brown adipose tissue
Available to Purchase
Journal:
Bioscience Reports
Biosci Rep (1986) 6 (7): 621–631.
Published: 01 July 1986
... and the glucocorticoid dexamethasone both had weak stimulatory effects on the mRNA level. It is concluded that an increase in intracellular cAMP levels is a necessary and perhaps sufficient stimulus for the increase in thermogenin gene expression. However, at least under in vivo conditions, this increase requires...
