... the development of heart failure. Correspondence: Douglas G. Tilley ( [email protected] ) 03 07 2024 24 08 2024 12 09 2024 12 09 2024 © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society...

.... Therefore, mitochondria are important therapeutic targets in heart failure. Abcb10 is a member of the ABC transporter superfamily located in the inner mitochondrial membrane and plays an important role in haemoglobin synthesis, biliverdin transport, antioxidant stress, and stabilization of the iron...

...Wei Liu; Yuling Li; Yan Zhang; Su Li; Yuqiong Chen; Bing Han; Yao Lu The mortality of heart failure after acute myocardial infarction (AMI) remains high. The aim of the present study was to analyze hub genes and immune infiltration in patients with AMI and heart failure (HF). The study utilized...

... further studies. In this sense, the present study aims to review the current knowledge on venous endothelial function and dysfunction, and the general state of the venous tone in two important cardiovascular diseases of high incidence and morbimortality worldwide: hypertension and heart failure. Studies...

...Xuguang Xu; Tingbo Jiang; Yong Li; Liusha Kong The purpose of the present study was to evaluate whether endostatin overexpression could improve cardiac function, hemodynamics, and fibrosis in heart failure (HF) via inhibiting reactive oxygen species (ROS). The HF models were established by inducing...

... in heart failure and inhibition of cardiac remodeling after myocardial infarction (MI). The cardiovascular protective effect of ghrelin may be associated with anti-inflammation, anti-apoptosis, inhibited sympathetic nerve activation, regulated autophagy, and endothelial dysfunction. However, the molecular...

...Guoyu Wang; Ruzhu Wang; Zhongbao Ruan; Ling Liu; Yong Li; Li Zhu The aim of the present study was to determine the effect of microRNA (miR)-132 on cardiac fibrosis in myocardial infarction (MI)-induced heart failure and angiotensin (Ang) II-treated cardiac fibroblasts (CFs). Experiments were...

... light–dark cycle with free access to standard chow and tap water. Apelin-13 fibrosis heart failure phosphatidylinositol 3-kinase protein kinase B oxidative stress Chronic heart failure (CHF) is commonly caused by myocardial infarction (MI) [ 1 ]. Heart failure (HF) is preceded...

...Junjie He; Ying Lu; Xiaozheng Song; Xiaoxuan Gong; Yong Li The aim of the present study was to determine the roles of microRNA (miR)-146a on myocardial infarction (MI)-induced heart failure and cardiac remodeling. Experiments were carried out in Sprague-Dawley rats treated with ligation of left...

... elevated cys-C level and all-cause mortality and rehospitalization risk amongst patients with heart failure (HF). PubMed and Embase databases were searched until December 2017. All prospective observational studies that reported a multivariate-adjusted risk estimate of all-cause mortality...

...Xuan Li; Jia Liu; Qingguo Lu; Di Ren; Xiaodong Sun; Thomas Rousselle; Yi Tan; Ji Li Heart failure (HF) is a serious disease with high mortality. The incidence of this disease has continued to increase over the past decade. All cardiovascular diseases causing dysfunction of various physiological...

... than just increased fluid filtration. Lung endothelial cell permeability is regulated by pressure-dependent activation of nitric oxide synthase (NOS). Herein, we demonstrate that pressure-dependent NOS activation contributes to vascular failure and PE in a model of acute heart failure (AHF) caused...

...Yanhui Li; Yan Wang; Man Zou; Cong Chen; Yili Chen; Ruicong Xue; Yugang Dong; Chen Liu AMP-activated protein kinase (AMPK), a serine/threonine protein kinase, has been shown to exert a protective effect against cardiac hypertrophy and heart failure. Our previous reports have demonstrated that AMPK...

... ventricle (LV) assist device (LVAD) in patients with advanced heart failure (HF). Our aim was to evaluate the course of unloading-induced cardiac atrophy in rats with failing hearts, and to examine if increased isovolumic loading obtained by intraventricular implantation of an especially designed spring...

... cardiomyopathy at the advanced stage of iron overload. cardiomyopathy fibrosis hemochromatosis heart failure iron overload oxidative stress Hereditary (genetic) hemochromatosis and secondary iron-overload disorders are prevalent on an international scale [ 1 – 3 ]. Iron-overload...

...Xianli Wang; Qian Wang; Wei Guo; Yi Zhun Zhu HF (heart failure) after MI (myocardial infarction) is a major cause of morbidity and mortality worldwide. Recent studies have shown that hydrogen sulfide (H 2 S) has cardioprotective effects. Hence, we aimed to elucidate the potential effects of H 2 S...