... 11 04 2023 © 2023 The Author(s). 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . acute lymphoblastic leukemia anti-CD10 mAb immunotherapy...

...Zemin Wang; You Ge; Han Li; Gaoqiang Fei; Shuai Wang; Pingmin Wei Currently, the benefits of immune checkpoint inhibitor (ICI) therapy prediction via emerging biomarkers have been identified, and the association between genomic mutation signatures (GMS) and immunotherapy benefits has been widely...

... 2022 © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics chemotherapy. ferroptosis-related genes immunotherapy...

... losing the best opportunity for liver transplantation and surgical treatment. Therefore, effective treatment of HCC is particularly important in clinical practice. During the past decades, there have been considerable advances in the treatment of HCC, and immunotherapy is increasingly recognized...

... under the Creative Commons Attribution License 4.0 (CC BY) . bioinformatics analysis biomarkers Breast cancer immunotherapy prognosis Breast cancer occurs frequently in non-skin carcinoma and leading to death in America females at the second level, with 268600 new patients and 41760...

..., we analyzed the expression profiles and prognostic value of THUMPD1 in pan-cancer and gained insights into the correlation between THUMPD1 expression level and immunotherapy efficacy. Methods: Gene expression pattern and its correlation with prognosis, immune cell infiltration in pan-cancer were...

..., and MAPK pathways were influenced by EBFs. Anti-CTLA4 immunotherapy is more suitable for EBFs determining high-risk groups, but not anti-PD-1/PD-L1 therapy. 5-Fluorouracil, methotrexate, vorinostat are suitable to inhibit the function of EBFs. Our new findings provide novel insight into the prediction...

... investigated the predictive role of COL1A1, THBS2, and SPP1 in immunotherapy. Materials and methods: We identified differential genes (DEGs) that were up- and down-regulated in the three datasets (GSE26942, GSE13911, and GSE118916) and created protein–protein interaction (PPI) networks from the overlapping...

... to immunotherapy. The findings demonstrated that differences in immune responses may be important drivers of PCa progression and response to treatment. Therefore, this comprehensive assessment of the 22 immune cell types in the PCa Tumor Environment (TEM) provides insights on the mechanisms of tumor response...

...Zhiding Wang; Mengzhen Wang; Jinghong Chen; Linlin Zhang; Li Zhang; Li Yu Cancer immunotherapy has recently undergone rapid development into a validated therapy for clinical use. The adoptive transfer of engineered autologous T cells, such as chimeric antigen receptor (CAR) T cells, has been...

...Hongyu Zhou; Lihua Chen; Mei Qin; Yajie Lei; Tianjiao Li; Haoran Li; Xi Cheng Tumor mutation burden (TMB) is an essential biomarker to predict immunotherapy response. TMB measurement was mainly evaluated by whole-exome sequencing (WES), which was costly and difficult to be widely applied...

...” R-package was employed to identify the three types of molecular classification and analyze the functional enrichment in each subclass. Response to immunotherapy and anticancer drug targets was predicted via TIDE algorithm and GDSC dataset. Results : Substantial variation reflecting individual...

..., suggesting PEG3 mutation might play a guiding role in prognosis prediction and immunotherapy selection in breast cancer. Correspondence: Jin Zhang ( [email protected] ) 13 05 2020 22 07 2020 28 07 2020 30 07 2020 The SignatureAnalyzer [ 24 ] was used for extraction...

... functional pathways as well as immune infiltrating cells, which may provide more data about the development of chRCC immunotherapy. We used the ‘Limma’ R package to identify differentially expressed genes in the high and low TMB groups with a fold change (FC) of 2 and P -value of 0.05. And the result...

...Zheng Wang; Xiaoli Tang; Xiaoqing Wu; Meiyuan Yang; Daorong Wang Objectives Mismatch repair (MMR) and Microsatellite instability (MSI) are critical when considering immunotherapy and chemotherapeutic drugs an option for patients with colorectal cancer (CRC). We investigated the consistence of MMR...

...Huan-huan Sha; Dan-dan Wang; Da-li Yan; Yong Hu; Su-jin Yang; Si-wen Liu; Ji-feng Feng Chimaeric antigen receptor (CAR) T-cell therapies, as one of the cancer immunotherapies, have heralded a new era of treating cancer. The accumulating data, especially about CAR-modified T cells against CD19...