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Keywords: inhibitor
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Articles

Identification of the target and mode of action for the prokaryotic nucleotide excision repair inhibitor ATBC

Open Access
Lorenzo Bernacchia, Antoine Paris, Arya Gupta, Alexandra A. Moores, Neil M. Kad
Journal: Bioscience Reports
Biosci Rep (2022) 42 (6): BSR20220403.
https://doi.org/10.1042/BSR20220403
Published: 30 May 2022
... with adjuvants, such as UV light. To date, only one known chemical inhibitor of NER is 2-(5-amino-1,3,4-thiadiazol-2-yl)benzo(f)chromen-3-one (ATBC) exists and targets Mycobacterium tuberculosis NER. To enable the design of future drugs, we need to understand its mechanism of action. To determine the mechanism...
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Includes: Supplementary data
Articles

Baicalin suppresses lung cancer growth by targeting PDZ-binding kinase/T-LAK cell-originated protein kinase

Open Access
Xin Diao, Danfen Yang, Yu Chen, Wentian Liu
Journal: Bioscience Reports
Biosci Rep (2019) 39 (4): BSR20181692.
https://doi.org/10.1042/BSR20181692
Published: 09 April 2019
.... The PBK/TOPK downstream signaling molecules Histone H3 and ERK2 in tumor tissues were also decreased after baicalin treatment. Taken together, baicalin can inhibit proliferation of lung cancer cells as a PBK/TOPK inhibitor both in vitro and in vivo . Correspondence: Wentian Liu ( [email protected]...
View articletitled, Baicalin suppresses lung cancer growth by targeting PDZ-binding kinase/T-LAK cell-originated protein kinase
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Articles

Genetic and structural validation of Aspergillus fumigatus N -acetylphosphoglucosamine mutase as an antifungal target

Open Access
Wenxia Fang, Ting Du, Olawale G. Raimi, Ramón Hurtado-Guerrero, Karina Mariño, Adel F. M. Ibrahim, Osama Albarbarawi, Michael A. J. Ferguson, Cheng Jin, Daan M. F. Van Aalten
Journal: Bioscience Reports
Biosci Rep (2013) 33 (5): e00063.
https://doi.org/10.1042/BSR20130053
Published: 04 September 2013
... structure of Af AGM1 revealed an amino acid change in the active site compared with the human enzyme, which could be exploitable in the design of selective inhibitors. Af AGM1 inhibitors were discovered by high-throughput screening, inhibiting the enzyme with IC 50 s in the low μM range. Together...
View articletitled, Genetic and structural validation of Aspergillus fumigatus N -acetylphosphoglucosamine mutase as an antifungal target
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