... component of innate immunity still remains unclear. We and others have recently identified that stimulation of IFN signalling cascades promotes the formation of a novel cytosolic structure in human cells that is enriched in ADP-ribosyl modifications. Here, we propose to name these structures ‘interferon...

... under the Creative Commons Attribution License 4.0 (CC BY) . ATPase host-pathogen interactions innate immunity interferons RNA-binding proteins The reporter gene assay confirmed the TRBP-mediated Cardiovirus -triggered IFNβ promoter activity in 293FT cells. MDA5 alone enhanced both...

... to cause tissue damage. Also, the absence of amoebic tropism for the mouse liver is correlated with resistance to experimental liver amoebiasis. Correspondence: Alfonso Olivos-García ( [email protected] ) complement Entamoeba histolytica innate immunity resistance to amoebiasis Entamoeba...

... Entamoeba histolytica innate immunity resistance to amoebiasis Entamoeba histolytica is the protozoan parasite responsible for human amoebiasis that causes approximately 100,000 deaths each year worldwide [ 1 ]. It is an exclusive human disease and the parasite life cycle has not been reproduced...

...Lena Völlger; Kathryn Akong-Moore; Linda Cox; Oliver Goldmann; Yanming Wang; Simon T. Schäfer; Hassan Y. Naim; Victor Nizet; Maren von Köckritz-Blickwede Neutrophil extracellular trap (NET) formation is a significant innate immune defense mechanism against microbial infection that complements other...

... at the cellular and molecular levels. Here we review the roles of these two metal ions in providing protection against infectious diseases in vivo , and in regulating innate immune responses. In particular, we focus on studies implicating zinc and copper in macrophage antimicrobial pathways, as well...