Page 1 | Search Results | Bioscience Reports

1-43 of 43

Sort by

Sort Order Select

Articles

Ginger extract promotes pancreatic islets regeneration in streptozotocin-induced diabetic rats

Manal S. Abbood, Amani M. Al-Adsani, Suzanne A. Al-Bustan

Biosci Rep (2025) 45 (03): BSR20241510.

https://doi.org/10.1042/BSR20241510

Published: 13 March 2025

... on the differential expression of neurogenin-3 ( Neurog3 ), V-maf musculoaponeurotic fibrosarcoma oncogene homolog B ( Mafb ), insulin 2 ( Ins2 ), and glucagon ( Gcg ) was assessed using quantitative real-time PCR after one and eight weeks of treatment. The pancreatic insulin source was determined using...

View article titled, Ginger extract promotes pancreatic islets regeneration in streptozotocin-induced diabetic rats

Articles

Metabolic hormones are integral regulators of female reproductive health and function

Faria Athar, Muskan Karmani, Nicole M. Templeman

Biosci Rep (2024) 44 (1): BSR20231916.

https://doi.org/10.1042/BSR20231916

Published: 31 January 2024

... metabolic hormones—including insulin, the incretins (glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1), growth hormone, ghrelin, leptin, and adiponectin—signal throughout the hypothalamic–pituitary–gonadal axis to support or suppress reproduction. We synthesize current knowledge...

View article titled, Metabolic hormones are integral regulators of female reproductive health and function

Articles

Lipid-based nutritional supplement impact on energy intake, appetite, glucose and insulin levels in under-weight pregnant and lactating women with preeclampsia

Nabila Sher Mohammad, Rubina Nazli, Sadia Fatima, Fozia Fozia, Hafza Zafar, Mashal Zafar, Zarghuna Zafar, Warda Khan, Mahmoud M.A. Abulmeaty, Dara Aldisi, Juan E. Andrade Laborde, Mourad A.M. Aboul-Soud

Biosci Rep (2024) 44 (1): BSR20231344.

https://doi.org/10.1042/BSR20231344

Published: 25 January 2024

... (LNS-PLW) on appetite score, energy intake, insulin and glucose levels in preeclamptic women. Design and participiants: Sixty under-weight preeclamptic primigravida were divided into two groups randomly and provided LNS-PLW/placebo in the fasted state. Blood samples were collected at fasting state...

View article titled, Lipid-based nutritional supplement impact on energy intake, appetite, glucose and insulin levels in under-weight pregnant and lactating women with preeclampsia

Articles

GLUT4 dispersal at the plasma membrane of adipocytes: a super-resolved journey

Angéline Geiser, Shannan Foylan, Peter W. Tinning, Nia J. Bryant, Gwyn W. Gould

Biosci Rep (2023) 43 (10): BSR20230946.

https://doi.org/10.1042/BSR20230946

Published: 20 October 2023

...Angéline Geiser; Shannan Foylan; Peter W. Tinning; Nia J. Bryant; Gwyn W. Gould In adipose tissue, insulin stimulates glucose uptake by mediating the translocation of GLUT4 from intracellular vesicles to the plasma membrane. In 2010, insulin was revealed to also have a fundamental impact...

View article titled, GLUT4 dispersal at the plasma membrane of adipocytes: a super-resolved journey

Articles

Insulin secretory actions of ethanolic extract of Acacia arabica bark in high fat-fed diet-induced obese Type 2 diabetic rats

Prawej Ansari, Sara S. Islam, Samia Akther, Joyeeta T. Khan, Jaber A. Shihab, Yasser H. A. Abdel-Wahab

Biosci Rep (2023) 43 (5): BSR20230329.

https://doi.org/10.1042/BSR20230329

Published: 23 May 2023

... study was to investigate the insulinotropic and antidiabetic properties of ethanol extract of Acacia arabica (EEAA) bark through in vitro and in vivo studies in high fat-fed (HFF) rats. EEAA at 40–5000 µg/ml significantly increased ( P <0.05–0.001) insulin secretion with 5.6 and 16.7 mM glucose...

View article titled, Insulin secretory actions of ethanolic extract of Acacia arabica bark in high fat-fed diet-induced obese Type 2 diabetic rats

Articles

SNAP23 decreases insulin secretion by competitively inhibiting the interaction between SNAP25 and STX1A

Jun Chen, Ziyan Wang, Tuanlao Wang, Jidong Cheng, Ruijuan Zhuang, Wei Wang

Biosci Rep (2023) 43 (5): BSR20222594.

https://doi.org/10.1042/BSR20222594

Published: 28 April 2023

...Jun Chen; Ziyan Wang; Tuanlao Wang; Jidong Cheng; Ruijuan Zhuang; Wei Wang SNAP25 is a core protein of the SNARE complex, which mediates stimulus-dependent secretion of insulin from the pancreatic β cells. SNAP23 is a SNAP25 homolog, however, the functional role of SNAP23 in the exocytic secretion...

View article titled, SNAP23 decreases insulin secretion by competitively inhibiting the interaction between SNAP25 and STX1A

Articles

EFR3 and phosphatidylinositol 4-kinase IIIα regulate insulin-stimulated glucose transport and GLUT4 dispersal in 3T3-L1 adipocytes

Anna M. Koester, Angéline Geiser, Kamilla M.E. Laidlaw, Silke Morris, Marie F.A. Cutiongco, Laura Stirrat, Nikolaj Gadegaard, Eckhard Boles, Hannah L. Black, Nia J. Bryant, Gwyn W. Gould

Biosci Rep (2022) 42 (7): BSR20221181.

https://doi.org/10.1042/BSR20221181

Published: 08 July 2022

...Anna M. Koester; Angéline Geiser; Kamilla M.E. Laidlaw; Silke Morris; Marie F.A. Cutiongco; Laura Stirrat; Nikolaj Gadegaard; Eckhard Boles; Hannah L. Black; Nia J. Bryant; Gwyn W. Gould Insulin stimulates glucose transport in muscle and adipocytes. This is achieved by regulated delivery...

View article titled, EFR3 and phosphatidylinositol 4-kinase IIIα regulate insulin-stimulated glucose transport and GLUT4 dispersal in 3T3-L1 adipocytes

Articles

Pyruvate accumulation may contribute to acceleration-induced impairment of physical and cognitive abilities: an experimental study

Fengfeng Mo, Hongwei Zhang, Yuxiao Tang, Ruirui Qi, Shuang Nie, Hui Shen, Min Li

Biosci Rep (2021) 41 (4): BSR20204284.

https://doi.org/10.1042/BSR20204284

Published: 14 April 2021

... into rats. Insulin can reduce the accumulation of pyruvate. To observe the insulin effect on pyruvate, cognitive and physical functions after acceleration, insulin administration or treatment of promoting insulin secretion was used. Physical and cognitive functions were assessed using open field test (OFT...

View article titled, Pyruvate accumulation may contribute to acceleration-induced impairment of physical and cognitive abilities: an experimental study

Includes: Supplementary data

Articles

Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats

Prawej Ansari, Mary P. Hannon-Fletcher, Peter R. Flatt, Yasser H.A. Abdel-Wahab

Biosci Rep (2021) 41 (1): BSR20203824.

https://doi.org/10.1042/BSR20203824

Published: 22 January 2021

...%; 38 ± 4%; 31±1%; 28±2%; 27±2%, respectively). A maximum of 45% inhibition was observed with >25 μM concentrations of selected phytochemicals (rutin). A. latifolia, A. marmelos, T. foenum-graecum and M. indica extracts improved glucose tolerance, insulin release, reduced DPP-IV activity...

View article titled, Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats

Articles

Biological efficacy of zinc oxide nanoparticles against diabetes: a preliminary study conducted in mice

Shafayet Ahmed Siddiqui, Md. Mamun Or Rashid, Md. Giash Uddin, Fataha Nur Robel, Mohammad Salim Hossain, Md. Azizul Haque, Md. Jakaria

Biosci Rep (2020) 40 (4): BSR20193972.

https://doi.org/10.1042/BSR20193972

Published: 07 April 2020

... glucose levels were determined by the glucose oxidase method. The experimental results revealed that ZnONPs suggestively ( p <0.001) declined the blood glucose levels (39.79%), while these reductions were 38.78% for the cotreatment of ZnONPs and insulin, and 48.60% for insulin, respectively...

View article titled, Biological efficacy of zinc oxide nanoparticles against diabetes: a preliminary study conducted in mice

Articles

Commentary on Ivancic et al.: Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme

Giuseppe Grasso

Biosci Rep (2018) 38 (6): BSR20181555.

https://doi.org/10.1042/BSR20181555

Published: 28 November 2018

...://doi.org/10.1042/BSR20181416 ) proposes a new analytical technique capable to reveal some mechanistic insights into the regulation of insulin-degrading enzyme (IDE), a protein involved in the above-mentioned diseases. IDE is a multifaceted enzyme having different and not well-defined roles in the cell...

View article titled, Commentary on Ivancic et al.: Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme

Articles

Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme

Valerie A. Ivancic, Claire A. Krasinski, Qiuchen Zheng, Rebecca J. Meservier, Donald E. Spratt, Noel D. Lazo

Biosci Rep (2018) 38 (6): BSR20181416.

https://doi.org/10.1042/BSR20181416

Published: 07 November 2018

...Valerie A. Ivancic; Claire A. Krasinski; Qiuchen Zheng; Rebecca J. Meservier; Donald E. Spratt; Noel D. Lazo Insulin-degrading enzyme (IDE) is a zinc metalloprotease that selectively degrades biologically important substrates associated with type 2 diabetes and Alzheimer’s disease (AD...

View article titled, Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme

Includes: Supplementary data

Articles

Central and peripheral effects of physical exercise without weight reduction in obese and lean mice

Francine Pereira de Carvalho, Thaís Ludmilla Moretto, Izabelle Dias Benfato, Marcela Barthichoto, Sandra Mara Ferreira, José Maria Costa-Júnior, Camila Aparecida Machado de Oliveira

Biosci Rep (2018) 38 (2): BSR20171033.

https://doi.org/10.1042/BSR20171033

Published: 05 March 2018

...) and insulin (Akt and p-Akt) signaling were evaluated. Glucose and leptin tolerance, peripheral insulin sensitivity, and plasma insulin, leptin and adiponectin were determined. Perigonadal and retroperitoneal fat depots were increased by diet but reduced by exercise despite lack of effect of exercise on body...

View article titled, Central and peripheral effects of physical exercise without weight reduction in obese and lean mice

Articles

Impaired insulin/IGF-1 is responsible for diabetic gastroparesis by damaging myenteric cholinergic neurones and interstitial cells of Cajal

Shu Yang, Bo Wu, Haimei Sun, Tingyi Sun, Kai Han, Dandan Li, Fengqing Ji, Guoquan Zhang, Deshan Zhou

Biosci Rep (2017) 37 (5): BSR20170776.

https://doi.org/10.1042/BSR20170776

Published: 27 October 2017

...Shu Yang; Bo Wu; Haimei Sun; Tingyi Sun; Kai Han; Dandan Li; Fengqing Ji; Guoquan Zhang; Deshan Zhou Diabetic gastroparesis is a common complication of diabetes mellitus (DM) that is characterized by decreased serum insulin and insulin-like growth factor-1 (IGF-1). Despite the fact that insulin...

View article titled, Impaired insulin/IGF-1 is responsible for diabetic gastroparesis by damaging myenteric cholinergic neurones and interstitial cells of Cajal

Includes: Supplementary data

Articles

Fasting insulin, insulin resistance, and risk of cardiovascular or all-cause mortality in non-diabetic adults: a meta-analysis

Xiaohong Zhang, Jun Li, Shuiping Zheng, Qiuyun Luo, Chunmei Zhou, Chaoyang Wang

Biosci Rep (2017) 37 (5): BSR20170947.

https://doi.org/10.1042/BSR20170947

Published: 07 September 2017

...Xiaohong Zhang; Jun Li; Shuiping Zheng; Qiuyun Luo; Chunmei Zhou; Chaoyang Wang Studies on elevated fasting insulin or insulin resistance (IR) and cardiovascular or all-cause mortality risk in non-diabetic individuals have yielded conflicting results. This meta-analysis aimed to evaluate...

View article titled, Fasting insulin, insulin resistance, and risk of cardiovascular or all-cause mortality in non-diabetic adults: a meta-analysis

Includes: Supplementary data

Articles

Insulin down-regulates the expression of ubiquitin E3 ligases partially by inhibiting the activity and expression of AMP-activated protein kinase in L6 myotubes

Hu-Ping Deng, Jia-Ke Chai, Chuan-An Shen, Xi-Bo Zhang, Li Ma, Tian-Jun Sun, Qing-Gang Hu, Yun-Fei Chi, Ning Dong

Biosci Rep (2015) 35 (4): e00242.

https://doi.org/10.1042/BSR20150017

Published: 20 August 2015

...Hu-Ping Deng; Jia-Ke Chai; Chuan-An Shen; Xi-Bo Zhang; Li Ma; Tian-Jun Sun; Qing-Gang Hu; Yun-Fei Chi; Ning Dong While insulin is an anabolic hormone, AMP-activated protein kinase (AMPK) is not only a key energy regulator, but it can also control substrate metabolism directly by inducing skeletal...

View article titled, Insulin down-regulates the expression of ubiquitin E3 ligases partially by inhibiting the activity and expression of AMP-activated protein kinase in L6 myotubes

Articles

Acute regulation of 5′-AMP-activated protein kinase by long-chain fatty acid, glucose and insulin in rat primary adipocytes

Abdel Hebbachi, David Saggerson

Biosci Rep (2013) 33 (1): e00007.

https://doi.org/10.1042/BSR20120031

Published: 13 December 2012

... in the adipocyte AMP:ATP ratio. Glucose decreased AMPK activity and effects of palmitate and glucose on AMPK activity were antagonistic. While insulin had no effect on basal AMPK activity insulin did decrease AMPK activity in the presence of palmitate and also decreased the percentage effectiveness of palmitate...

View article titled, Acute regulation of 5′-AMP-activated protein kinase by long-chain fatty acid, glucose and insulin in rat primary adipocytes

Includes: Supplementary data

Articles

Mitochondrial dysfunction in insulin resistance: differential contributions of chronic insulin and saturated fatty acid exposure in muscle cells

Chenjing Yang, Cho Cho Aye, Xiaoxin Li, Angels Diaz Ramos, Antonio Zorzano, Silvia Mora

Biosci Rep (2012) 32 (5): 465–478.

https://doi.org/10.1042/BSR20120034

Published: 08 August 2012

...Chenjing Yang; Cho Cho Aye; Xiaoxin Li; Angels Diaz Ramos; Antonio Zorzano; Silvia Mora Mitochondrial dysfunction has been associated with insulin resistance, obesity and diabetes. Hyperinsulinaemia and hyperlipidaemia are hallmarks of the insulin-resistant state. We sought to determine...

View article titled, Mitochondrial dysfunction in insulin resistance: differential contributions of chronic insulin and saturated fatty acid exposure in muscle cells

Includes: Supplementary data

Articles

Regulation of synaptic functions in central nervous system by endocrine hormones and the maintenance of energy homoeostasis

Zhiping P. Pang, Weiping Han

Biosci Rep (2012) 32 (5): 423–432.

https://doi.org/10.1042/BSR20120026

Published: 20 July 2012

... of energy homoeostasis [ 1 , 3 , 7 – 9 ]. Among all the hormones related to feeding behaviour and cognition, leptin, insulin and ghrelin are among the best characterized. Figure 1 Hypothalamic neurocircuitry regulates food intake ( A ) Hypothalamus is the primary brain region that responds...

View article titled, Regulation of synaptic functions in central nervous system by endocrine hormones and the maintenance of energy homoeostasis

Articles

Inactivation of the AMP-activated protein kinase by glucose in cardiac myocytes: a role for the pentose phosphate pathway

Ikhlass Tabidi, David Saggerson

Biosci Rep (2012) 32 (3): 229–239.

https://doi.org/10.1042/BSR20110075

Published: 22 December 2011

.... The glucose effect was additive to the decrease in AMPK activity caused by insulin, was attenuated by adrenaline, was not mimicked by glucose analogues, lactate or pyruvate and was not due to changes in myocyte glycogen content. AMPK activity was decreased by xylitol and PMS (phenazine methosulfate...

View article titled, Inactivation of the AMP-activated protein kinase by glucose in cardiac myocytes: a role for the pentose phosphate pathway

Includes: Supplementary data

Articles

5′-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes

Yugo Tsuchiya, Fiona C. Denison, Richard B. Heath, David Carling, David Saggerson

Biosci Rep (2012) 32 (2): 197–209.

https://doi.org/10.1042/BSR20110076

Published: 21 November 2011

... kinase) cascade inhibitor U0126 or by PTX (pertussis toxin). Adrenaline caused no measurable change in LKB1 activity. Adrenaline decreased AMPK activity through a process that was distinct from AMPK inactivation in response to insulin or PMA. Neither adrenaline nor PMA altered the myocyte AMP:ATP ratio...

View article titled, 5′-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes

Includes: Supplementary data

Articles

Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes

Patrick D. Lyons, Grantley R. Peck, Arminja N. Kettenbach, Scott A. Gerber, Liya Roudaia, Gustav E. Lienhard

Biosci Rep (2009) 29 (4): 229–235.

https://doi.org/10.1042/BSR20080162

Published: 07 May 2009

...Patrick D. Lyons; Grantley R. Peck; Arminja N. Kettenbach; Scott A. Gerber; Liya Roudaia; Gustav E. Lienhard The signal transduction pathway leading from the insulin receptor to stimulate the fusion of vesicles containing the glucose transporter GLUT4 with the plasma membrane in adipocytes...

View article titled, Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes

Articles

Modulation by Leptin, Insulin and Corticosterone of Oleoyl-estrone Synthesis in Cultured 3T3 L1 Cells

M. Esteve, P. Savall, J. Virgilli, J.A. Fernández-López, X. Remesar, M. Alemany

Biosci Rep (2001) 21 (6): 755–763.

https://doi.org/10.1023/A:1015580623325

Published: 01 December 2001

...M. Esteve; P. Savall; J. Virgilli; J.A. Fernández-López; X. Remesar; M. Alemany Preadipocytes (3T3 L1) were used between 7 and 14 days after differentiation; they were incubated with 44 nM 3H-esterone. The medium was supplemented with 1 μM recombinant murine leptin, 10 nM recombinant human insulin...

View article titled, Modulation by Leptin, Insulin and Corticosterone of Oleoyl-estrone Synthesis in Cultured 3T3 L1 Cells

Articles

Mitochondrial Dehydrogenases in Different Taxa of Tetrahymena: Effect of Insulin

L. Kőhidai, G. Csaba

Biosci Rep (1997) 17 (6): 529–535.

https://doi.org/10.1023/A:1027308223168

Published: 01 December 1997

...L. Kőhidai; G. Csaba Mitochondrial dehydrogenase activity was measured in seven taxa of Tetrahymena (T. pyriformis G1, T. hegewishi, T. malaccensis, T. pigmentosa, T. shapiro, T. thermophila CU-399, T. thermophila MS-1). Enzyme activity was different in the taxa investigated. Insulin reduced enzyme...

View article titled, Mitochondrial Dehydrogenases in Different Taxa of Tetrahymena: Effect of Insulin

Articles

D-Glucose but Not Insulin Reduces N-formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe)-Induced Shape Changes in Suspended Human Neutrophils

Per-Arne Oldenborg, Janove Sehlin

Biosci Rep (1997) 17 (5): 475–486.

https://doi.org/10.1023/A:1027347904512

Published: 01 October 1997

...Per-Arne Oldenborg; Janove Sehlin The effects of glucose (5–25 mM) and insulin concentration (40–320 μU/ml) on the cell shape of neutrophil granulocytes from healthy humans were studied. Both non-activated and N-formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe)-activated neutrophils...

View article titled, D-Glucose but Not Insulin Reduces N-formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe)-Induced Shape Changes in Suspended Human Neutrophils

Articles

Endosomes, receptor tyrosine kinase internalization and signal transduction

John J. M. Bergeron, G. M. Di Guglielmo, Patricia C. Baass, François Authier, Barry I. Posner

Biosci Rep (1995) 15 (6): 411–418.

https://doi.org/10.1007/BF01204345

Published: 01 December 1995

...John J. M. Bergeron; G. M. Di Guglielmo; Patricia C. Baass; François Authier; Barry I. Posner Upon the binding of insulin or epidermal growth factor to their cognate receptors on the liver parenchymal plasmalemma, signal transduction and receptor internalization are near co-incident. Indeed...

View article titled, Endosomes, receptor tyrosine kinase internalization and signal transduction

Articles

Evidence that protein kinase C and mitogen activated protein kinase are not involved in the mechanism by which insulin stimulates translation in L6 myoblasts

Michael G. Thompson, Monique Pascal, Steven C. Mackie, Amanda Thom, Kenneth S. Morrison, F. R. Colette Backwell, Robert M. Palmer

Biosci Rep (1995) 15 (1): 37–46.

https://doi.org/10.1007/BF01200213

Published: 01 February 1995

...Michael G. Thompson; Monique Pascal; Steven C. Mackie; Amanda Thom; Kenneth S. Morrison; F. R. Colette Backwell; Robert M. Palmer Insulin stimulated a concentration-dependent increase in protein synthesis in L6 myoblasts which was significant at 1 nM. This response was not prevented...

View article titled, Evidence that protein kinase C and mitogen activated protein kinase are not involved in the mechanism by which insulin stimulates translation in L6 myoblasts

Articles

Effect of insulin on the incorporation of 3 H-inositol into the inositol phospholipids (PI, PIP, PIP 2 ) and Glycosyl-phoshatidylinositols (GPIs) of Tetrahymena pyriformis

P. Kovács, G. Csaba

Biosci Rep (1994) 14 (5): 215–219.

https://doi.org/10.1007/BF01209726

Published: 01 October 1994

...P. Kovács; G. Csaba The unicellular tetrahymena contains inositol phospholipids (PI, PIP, PIP 2 ) and GPIs. Treatment with 10 −5 M insulin decreases the total 3 H-inositol incorporation and incorporation into PI. 24 h after 10 −6 M insulin treatment there is an elevation of these parameters. Second...

View article titled, Effect of insulin on the incorporation of 3 H-inositol into the inositol phospholipids (PI, PIP, PIP 2 ) and Glycosyl-phoshatidylinositols (GPIs) of Tetrahymena pyriformis

Articles

A role for tyrosine kinase activation in interleukin-1β induced nitric oxide production in the insulin producing cell line RINm-5F

Nils Welsh

Biosci Rep (1994) 14 (1): 43–50.

https://doi.org/10.1007/BF01901637

Published: 01 February 1994

...Nils Welsh The aim of this investigation was to study the putative role of protein phosphorylation in interleukin-1β (IL-1β) induced signal transduction in insulin producing cells. For this purpose, insulin producing RINm-5F cells were exposed to IL-1β for 7 hours with or without different agonists...

View article titled, A role for tyrosine kinase activation in interleukin-1β induced nitric oxide production in the insulin producing cell line RINm-5F

Articles

Arachidonate activation of protein kinase C may be involved in the stimulation of protein synthesis by insulin in L6 myoblasts

Michael G. Thompson, Fiona Acamovic, Steven C. Mackie, Kenneth S. Morrison, Robert M. Palmer

Biosci Rep (1993) 13 (6): 359–366.

https://doi.org/10.1007/BF01150480

Published: 01 December 1993

...Michael G. Thompson; Fiona Acamovic; Steven C. Mackie; Kenneth S. Morrison; Robert M. Palmer Insulin stimulated protein synthesis in L6 myoblasts but did not increase the labelling of DAG or the release of phosphocholine from phosphatidylcholine. The DAG lipase inhibitor, RHC 80267, more than...

View article titled, Arachidonate activation of protein kinase C may be involved in the stimulation of protein synthesis by insulin in L6 myoblasts

Articles

Protein phosphorylation and cellular regulation I

Edwin G. Krebs

Biosci Rep (1993) 13 (3): 127–142.

https://doi.org/10.1007/BF01149958

Published: 01 June 1993

... Publishing Corporation 1993 protein phosphorylation protein kinase phosphorylase glycogen metabolism normonal signaling cyclic AMP cyclic AMP-dependent protein kinase insulin growth factors Bioscience Reports, Vol. 13, No. 3, 1993 NOBEL LECTURE 9 DECEMBER 1992 Protein Phosphorylation...

View article titled, Protein phosphorylation and cellular regulation I

Articles

Interaction between perchlorate and nifedipine on insulin secretion from mouse pancreastic islets

Gerd Larsson-Nyrén, Janove Sehlin

Biosci Rep (1993) 13 (2): 107–117.

https://doi.org/10.1007/BF01145963

Published: 01 April 1993

...Gerd Larsson-Nyrén; Janove Sehlin In order to elucidate the mechanisms responsible for the stimulatory effect of perchlorate (ClO 4 − ) on insulin secretion, we have investigated the interaction between this chaotropic anion and the organic calcium antagonist nifedipine. This drug, known...

View article titled, Interaction between perchlorate and nifedipine on insulin secretion from mouse pancreastic islets

Articles

Insulin-dependent release of 5′-nucleotidase and alkaline phosphatase from liver plasma membranes

Sandra Incerpi, Patrizia Baldini, Mario Lo Bello, Paolo Luly

Biosci Rep (1992) 12 (2): 101–108.

https://doi.org/10.1007/BF02351214

Published: 01 April 1992

...Sandra Incerpi; Patrizia Baldini; Mario Lo Bello; Paolo Luly Insulin treatment of isolated liver plasma membranes induced the release of 5′-nucleotidase and alkaline phosphatase. This effect was maximal at physiological hormone concentrations, being 36% and 17% for 5′-nucleotidase and alkaline...

View article titled, Insulin-dependent release of 5′-nucleotidase and alkaline phosphatase from liver plasma membranes

Articles

Insulin antagonizes the phagocytosis stimulating action of histamine in Tetrahymena

G. Csaba, Zsuzsa Darvas

Biosci Rep (1992) 12 (1): 23–27.

https://doi.org/10.1007/BF01125824

Published: 01 February 1992

...G. Csaba; Zsuzsa Darvas Histamine increased specifically the phagocytic activity of the unicellular Tetrahymena, whereas insulin had no influence on it. Insulin antagonized the phagocytosis stimulating action of histamine after simultaneous exposure and after preexposure two days earlier as well...

View article titled, Insulin antagonizes the phagocytosis stimulating action of histamine in Tetrahymena

Articles

Alpha 2 -adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic β-cells

Krister Bokvist, Carina Ämmälä, Per-Olof Berggren, Patrik Rorsman, Karin Wåhlander

Biosci Rep (1991) 11 (3): 147–157.

https://doi.org/10.1007/BF01182483

Published: 01 June 1991

.... In addition, when Ca 2+ -currents were recorded from intact β-cells, using the perforated patch whole-cell configuration, clonidine (1 μM) also failed to detectably affect the Ca 2+ -current. It is therefore suggested that the inhibition of β-cell electrical activity and insulin-secretion produced by α 2...

View article titled, Alpha 2 -adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic β-cells

Articles

Evidence for the involvement of vicinal sulfhydryl groups in the insulin stimulation of intracellular glucose metabolism in Zajdela Hepatoma cells

Martine Caron, Gisèle Cherqui, Denise Wicek, Brigitte Melin, Christine Reynet, Jacqueline Capeau, Jacques Picard

Biosci Rep (1990) 10 (1): 23–29.

https://doi.org/10.1007/BF01116847

Published: 01 February 1990

...Martine Caron; Gisèle Cherqui; Denise Wicek; Brigitte Melin; Christine Reynet; Jacqueline Capeau; Jacques Picard Phenylarsine oxide (PhAsO), a dithiol reagent that blocks insulin stimulation of glucose transport in 3T3 L1 cells, also altered insulin stimulation of intracellular glucose metabolism...

View article titled, Evidence for the involvement of vicinal sulfhydryl groups in the insulin stimulation of intracellular glucose metabolism in Zajdela Hepatoma cells

Articles

Studies into hormonal imprinting in intact and transformed 3T3 fibroblast cell lines

P. Kovács, Y. Okano, Y. Nozawa, G. Csaba

Biosci Rep (1989) 9 (6): 721–725.

https://doi.org/10.1007/BF01114810

Published: 01 December 1989

...P. Kovács; Y. Okano; Y. Nozawa; G. Csaba The cells of the NIH 3T3 fibroblast line responded to primary interaction with insulin by a positive imprinting, i.e. by an increased binding capacity for the hormone on re-exposure. Positive imprinting, although to a lesser degree, was also induced...

View article titled, Studies into hormonal imprinting in intact and transformed 3T3 fibroblast cell lines

Articles

Interaction between diazepam and oral antidiabetic agents on serum glucose, insulin and chromium levels in rats

F. A. A. Al-Ahmed, E. S. M. El-Denshary, M. Zaki, H. A. El-Sawaf, A. R. Abu-Jayyab

Biosci Rep (1989) 9 (3): 347–350.

https://doi.org/10.1007/BF01114687

Published: 01 June 1989

...F. A. A. Al-Ahmed; E. S. M. El-Denshary; M. Zaki; H. A. El-Sawaf; A. R. Abu-Jayyab This study was undertaken to investigate the effect of diazepam in the presence and absence of glibenclamide, metformin or their combination on serum levels of glucose, insulin and chromium in rats. Results indicated...

View article titled, Interaction between diazepam and oral antidiabetic agents on serum glucose, insulin and chromium levels in rats

Articles

The influence of starvation and natural refeeding on the rate of triacylglycerol/fatty acid substrate cycling in brown adipose tissue and different white adipose sites of the rat in vivo . The role of insulin and the sympathetic nervous system

Stewart W. Mercer, Dermot H. Williamson

Biosci Rep (1988) 8 (2): 147–153.

https://doi.org/10.1007/BF01116459

Published: 01 April 1988

... of the tissue to refeeding, as did acute suppression of insulin secretion. Similarly, rats fasted for 3 days showed no acute increase in the activity of the cycle following refeeding. 3 2 1988 © 1988 Plenum Publishing Corporation 1988 triacylglycerol/fatty acid substrate cycling brown adipose...

View article titled, The influence of starvation and natural refeeding on the rate of triacylglycerol/fatty acid substrate cycling in brown adipose tissue and different white adipose sites of the rat in vivo . The role of insulin and the sympathetic nervous system

Articles

Effects of insulin, pertussis toxin and cholera toxin on protein synthesis and diacylglycerol production in 3T3 fibroblasts: Evidence for a G-protein mediated activation of phospholipase C in the insulin signal mechanism

John E. Hesketh, Gillian P. Campbell

Biosci Rep (1987) 7 (7): 533–541.

https://doi.org/10.1007/BF01119769

Published: 01 July 1987

...John E. Hesketh; Gillian P. Campbell The rapid increase in protein synthesis that occurs on addition of insulin (1 mU/ml) to stepped-down 3T3 cells was blocked by pre-incubation of the cells with pertussis toxin. Cholera toxin on the other hand stimulated protein synthesis and this effect...

View article titled, Effects of insulin, pertussis toxin and cholera toxin on protein synthesis and diacylglycerol production in 3T3 fibroblasts: Evidence for a G-protein mediated activation of phospholipase C in the insulin signal mechanism

Articles

Rapid response of protein synthesis to insulin in 3T3 cells: Effects of protein kinase C depletion and differences from the response to serum repletion

John E. Hesketh, Gillian P. Campbell, Peter J. Reeds

Biosci Rep (1986) 6 (9): 797–804.

https://doi.org/10.1007/BF01117102

Published: 01 September 1986

...John E. Hesketh; Gillian P. Campbell; Peter J. Reeds Quiescent 3T3 cells grown in media containing 4% foetal calf serum showed different responses to insulin and to serum repletion (to 12%). Insulin stimulated protein synthesis within 1 h and this early response was insensitive to actinomycin D...

View article titled, Rapid response of protein synthesis to insulin in 3T3 cells: Effects of protein kinase C depletion and differences from the response to serum repletion

Articles

Time dependent effect of indomethacin on the stimulation of protein synthesis in isolated rabbit muscle by insulin

R. M. Palmer, P. Bain, P. J. Reeds

Biosci Rep (1986) 6 (5): 485–491.

https://doi.org/10.1007/BF01116140

Published: 01 May 1986

...R. M. Palmer; P. Bain; P. J. Reeds Insulin (100 μU/ml) stimulated protein synthesis and PGF 2α release in isolated rabbit muscle, but had little effect on the rate of protein degradation. The effect of insulin persisted for at least 5 h after removal of the hormone. Indomethacin, added at the start...

View article titled, Time dependent effect of indomethacin on the stimulation of protein synthesis in isolated rabbit muscle by insulin

Articles

The response of muscle protein synthesis to nutrient intake in postabsorptive rats: The role of insulin and amino acids

V. R. Preedy, P. J. Garlick

Biosci Rep (1986) 6 (2): 177–183.

https://doi.org/10.1007/BF01115004

Published: 01 February 1986

... of anti-insulin serum suppressed the response to feeding and to intragastric infusion, but not to intravenous infusion. It is concluded that the response of muscle protein synthesis to food intake is mediated by both insulin and amino acids acting in concert. 27 1 1986 © 1986 Plenum Publishing...

View article titled, The response of muscle protein synthesis to nutrient intake in postabsorptive rats: The role of insulin and amino acids

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only