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Imran Haq, James A. Irving, Sarah V. Faull, Jennifer A. Dickens, Adriana Ordóñez, Didier Belorgey, Bibek Gooptu, David A. Lomas
Journal:
Bioscience Reports
Biosci Rep (2013) 33 (3): e00046.
Published: 25 June 2013
... surveyed the RCL (reactive centre loop) of α 1 -antitrypsin to identify sites important for progression, through intermediate states, to polymer. Mutations at P 14 P 12 and P 4 , but not P 10 P 8 or P 2 P 1′ , resulted in a decrease in detectable polymer in a cell model that recapitulates the intracellular...
